The presentation of mesenteric artery thrombosis is fairly consistent. The most common presenting complaint is abdominal pain which is classically out of proportion to the physical exam findings. Pain is typically moderate to severe, diffuse and constant. Other presenting symptoms may include nausea/vomiting, diarrhea, and rectal bleeding.  In a study of acute mesenteric ischemia, 95% of patients presented with abdominal pain, 44% presented with nausea, 35% presented with vomiting, 35% presented with diarrhea, and 16% presented with rectal bleeding.[5] A rapid deterioration of the clinical condition is common. Signs of peritonitis may be subtle, and the key to early diagnosis hinges on strong clinical suspicion.

Early detection and treatment are crucial in the management of mesenteric artery thrombosis. Reports exist that there is a 50% chance of survival if  diagnosis takes palce within 24 hours. However, survival drops to 30% if the diagnosis delays beyond the 24-hour window.[6] The initial evaluation should involve a basic set of laboratory analyses. The most common lab abnormalities are hemoconcentration, metabolic acidosis, with a  high lactate concentration, as well as leukocytosis. Hyperkalemia and hyperphosphatemia and typically late signs and often correlates with bowel infarction. Plain film evaluation of the abdomen is non-specific and typically not particularly helpful from a diagnostic standpoint. Mesenteric angiography was historically considered the gold standard in diagnostic evaluation. However, this has been supplanted by CT angiography, which not only provides exquisite detail of the vascular anatomy but also provides extremely useful information regarding the integrity of the affected bowel. CT findings such as pneumoperitoneum, pneumatosis, portal venous gas, and bowel wall thickening can provide valuable information which is critical in guiding therapy. Mesenteric artery thrombosis may also be diagnosed with magnetic resonance angiography (MRA), particularly when intravenous contrast cannot be administered. However, it is prone to an artifact which can limit diagnostic accuracy and is dependent on a compliant patient because of the length of the examination. Duplex sonography may be helpful in the evaluation of mesenteric patency, which can be of particular value in patients with profound renal insufficiency in whom intravenous contrast may have a detrimental and occasionally irreversible impact on renal function. However, duplex sonography it is heavily operator dependent and is subject to limitations by poor acoustic windows secondary to bowel distention.

Upon diagnosing mesenteric artery thrombosis, prompt, definitive treatment is essential. Aggressive fluid resuscitation is imperative to correct hypotension and metabolic derangement. If there is no absolute contraindication, anticoagulation with heparin sodium administered intravenously should be promptly initiated. Other intravenous medications such as glucagon and papaverine may help manage vasospasm which frequently accompanies the thrombotic event.  If peritoneal signs are present, bowel infarction should be presumed, and emergency laparotomy are necessary. If the occlusive source is embolic, a simple surgical embolectomy may be performed. If in-situ thrombosis is present, the underlying vessel is frequently too diseased to salvage. In these cases, a mesenteric bypass should be performed, ideally with an autologous vein to minimize the risk of contamination, particularly in cases with bowel perforation. Bowel resection should additionally be performed, as needed, at this time. Occasionally, second look surgery may be necessary to reassess the integrity of the small bowel. 

Patients with documented mesenteric thrombosis who have not developed peritoneal signs may be considered for minimally invasive treatment alternatives such as catheter-directed thrombolytic infusion. This approach involves the intra-arterial placement of an infusion catheter into the thrombosed segment of superior mesenteric artery followed by infusion of tissue plasminogen activator (TPA). Studies have shown TPA  to be very effective in dissolving acute superior mesenteric artery clot.[7][8] This procedure typically involves infusion over the course of 12 to 24 hours, and the benefits of this treatment modality should be weighed against the time required to complete therapy. Only stable patients should be considered for thrombolytic therapy. More recently, catheter-directed thrombectomy procedures utilizing small caliber intravascular thrombectomy devices have been used in conjunction with TPA with some degree of success, thereby shortening the length of treatment.[9]

The differential diagnosis of mesenteric artery thrombosis extensive, given the common presenting symptom of abdominal pain. Differential diagnoses include (but are not limited to):

• Acute colitis
• Bowel obstruction
• Abdominal aortic aneurysm
• Biliary obstruction
• Intestinal perforation
• Malignancy 

The prognosis of mesenteric artery thrombosis is generally poor. A large retrospective study found thirty-day postoperative morbidity of 56.6% and thirty-day mortality of 27.9%.[10] For patients undergoing surgical revascularization, the reported range of mortality rates is from 44 to 90%.[11]

• Short bowel syndrome
• Colostomy 
• Multiorgan failure
• Peritonitis
• Occlusion of vein graft
• Death

Mesenteric artery thrombosis is a serious illness with potentially catastrophic implications absent the initiation of prompt diagnosis and treatment. Diagnosis and treatment require an efficient, collaborative approach involving physicians, nursing, as well as laboratory and radiology personnel. Because there is no specific test to make the diagnosis of mesenteric artery thrombosis, the general surgeon should be consulted early in the care of the patient. Most patients need immediate resuscitation and treatment. The overall outlook for most patients is poor.[12][13]