A well-versed medical professional that is highly familiar and experienced with the type of block being performed should be performing the specific injection.

Taking a detailed medical history is necessary to determine conditions like coagulopathy or respiratory compromise that may impact the decision to perform a block. A thorough physical exam is prudent as well to determine preexisting sensory or motor deficits in the distribution of the block. Studies show that patients with preexisting sensory or motor deficits may be more likely to develop new deficits following a block than patients without preexisting deficits. Following the history and physical, the patient should be made familiar with the risks, benefits, and care needed during the recovery phase of the block.

For patients that are receiving a nerve block for a surgical procedure, they should follow the same fasting guidelines for the surgery as it may be necessary for deep sedation to be used in cases of an inadequate block. Also, intravenous access should be obtained due to the risk of potential complications like vasovagal events, local anesthetic toxicity, and the possible use of general anesthetics.

The technique for peripheral nerve blocks is based on the type of block. A quick summary of some of the more common blocks is listed below.

• Interscalene block: anesthetizes nerve roots from the cervical plexus (C3, C4, supraclavicular nerve) and upper and middle trunks of the brachial plexus (C5-C7). For positioning, the patient is placed in a supine position with the head turned away from the side of the block. Sternal notch, the sternal and clavicular heads of the sternocleidomastoid muscle, and clavicle are identified and marked. A probe is placed in a transverse position with its long axis across the neck just above the clavicle if using ultrasound. The carotid artery and internal jugular vein are visualized. The subclavian artery is identified by directing the beam towards the first rib. Nerves are then traced cephalad. At the C6 nerves of the brachial plexus are visualized in a vertical orientation within the interscalene groove. A needle is then placed in-plane or out-of-plane and directed toward the nerves. A needle tip is placed next to the nerve roots. A total of 12 cc to 30 cc of local anesthetic is injected.
• Supraclavicular block: the patient is placed in the supine position with arms by the sides and the head turned away from the side of the block. The probe is placed in a transverse position just above the clavicle using ultrasound. The carotid artery and internal jugular vein are visualized. The needle is inserted in-plane (parallel to the probe), and a local anesthetic is injected to hydro dissect between the nerves until the tip reaches an area bordered by the first rib, subclavian artery, and brachial plexus. 20 cc to 30 cc of local anesthetic is injected. Before injection, however, aspiration should be performed to ensure there is no blood.
• Infraclavicular block: the patient is placed in the supine position with the head turned away from the side of the block. The arm is abducted with the elbow flexed to identify the coracoid process. The axillary artery is identified, and the cords of the brachial plexus are visualized adjacent to the artery using ultrasound. The needle is placed adjacent to the axillary artery in the cranio-posterior quadrant, and 30 to 40 cc of local anesthetic is administered. Before injection, however, aspiration should be performed to ensure there is no blood
• Axillary block: block anesthetizes nerves of the brachial plexus at the level of the individual nerves and often requires multiple injections. The patient is positioned supine with the arm abducted 90 degrees, and the elbow is flexed. The transducer is placed transversely in the axilla using ultrasound. The needle is introduced perpendicular to the skin and advanced until the tip is next to each nerve.
• Intercostobrachial block: the patient is positioned supine with the arm abducted to expose the axillary fossa. The intercostobrachial nerve runs in the subcutaneous tissue of the medial upper arm. The needle is advanced subcutaneously across the medial aspect of the arm while injecting 5 cc to 10 cc of local anesthetic.
• Radial nerve block: radial nerve emerges between the brachioradialis tendon and the radius, just proximal to the styloid process. The needle is inserted subcutaneously, just proximal to the styloid process of the radius, aiming medially, and 3 cc to 5cc of local anesthetic is injected.
• The median nerve block is located between the tendons of the flexor palmaris longus and the flexor carpi radialis. The need is inserted between the two tendons until it penetrates the fascia and advanced until contact is made with bone. The needle should be redirected and local anesthetic injected in lateral and medial directions.
• Ulnar nerve block: ulnar nerve runs between the ulnar artery and flexor carpi ulnaris tendon. The tendon is just superficial to the ulnar nerve. A needle is placed under the tendon close to its attachment just above the styloid process of the ulna and advanced 5 mm to 10 mm, and 3 cc to 5 cc of local anesthetic is injected at this location.
• Lumbar plexus block: The patient is placed in the lateral decubitus position operative side up with the leg flexed at the hip and knee. It is placed longitudinally adjacent to the spine at the second to third lumbar level using the ultrasound probe. The needle is inserted at the cephalad edge using the in-plane technique. The length of the needle should be seen as it approaches the target structure, which the posterior third of the psoas major muscle.
• Femoral nerve block: The patient is placed in a supine position. Using ultrasound, the nerve is visualized, which is lateral to the artery. An in-plane or out-of-plane approach can be used where the needle is inserted, and the tip is placed adjacent to the nerve, and 20 cc to 50 cc of local anesthetic is injected in 5 cc increments. Before injection, however, aspiration should be performed to ensure there is no blood.
• Fascia iliaca block: the patient is placed in a supine position where using ultrasound, the probe is placed transversely to the leg at the junction of the middle and lateral thirds (between the ASIS and pubic tubercle) to identify the fascia lata, iliacus muscle, and fascia iliaca. The needle is introduced in-plane inferior to the inguinal ligament and guided beneath the fascia iliaca, and 30 cc of local anesthetic is injected in 5 cc increments. Before injection, however, aspiration should be performed to ensure there is no blood.
• Obturator nerve block: the patient is placed in the supine position with the leg externally rotated. Using an ultrasound probe, it is placed in the inguinal crease, and the femoral vein is identified. The probe is then moved medially to visualize the pectineus and adductor longus muscles. The needle is inserted inplane or out of plane and is directed to the fascial plane between the adductor brevis and magnus, and 5 cc to 10 cc of local anesthetic is injected. Before injection, however, aspiration should be performed to ensure there is no blood.
• Sciatic nerve block: can be approached anteriorly or posteriorly. The patient is placed in the lateral decubitus position with the hip flexed at 45 degrees and the knee at 90 degrees for the posterior approach. In the anterior approach, the patient is positioned in the same manner. Using an ultrasound probe, it is held transverse to the course of the nerve. The nerve is found lateral to the ischial tuberosity and deep to the gluteus maximus muscle. The needle is inserted in-plane from the lateral aspect of the transducer and positioned with the tip of the needle adjacent to the nerve. Approximately 20 cc of local anesthetic is injected in 5 cc increments with gentle aspirations between injections. Before injection, however, aspiration should be performed to ensure there is no blood.
• Popliteal nerve block: the patient can be placed in either prone, lateral decubitus, or supine. There are two approaches. For the posterior approach, the biceps femoris and semitendinosus/semimembranosus tendons are palpated. The ultrasound probe is placed transverse to the thigh and in the popliteal crease. The popliteal artery is used as the landmark, and the tibial nerve is found superficial and lateral to the popliteal artery. The nerve is then followed cephalad to the point where the common fibular nerve joins the tibial nerve from the lateral side to form the sciatic nerve. The sciatic nerve is blocked proximal to this to ensure that both the common fibular and tibial nerves are anesthetized.
• Saphenous nerve block: the patient is positioned supine with the leg straight. Using the ultrasound probe, it is placed perpendicularly to the thigh at the midpoint between the anterior superior iliac spine and the distal end of the femur. The nerve is identified as it exits from the adductor canal adjacent to the femoral artery. As it is followed distally, it becomes more superficial, traveling with an arterial branch just deep to the sartorius muscle. Using an in-plane approach 10 cc of local anesthetic is injected deep to the sartorius muscle at the lateral border of the artery. 

Potential complications and side effects are dependent upon the type of block performed. However, complications include peripheral nerve injury (although not common, the rate may be as high as 8% to 10%), hematoma, local anesthetic systemic toxicity, allergic reaction, infection, and a secondary injury, which includes reduced sensation after nerve block.[4][5][6]

Peripheral nerve blocks are often performed by anesthesiologists, surgeons, and emergency department physicians. However, a dedicated nurse must monitor the patient's vital signs during the procedure. More important, resuscitation equipment must be in the room before starting the procedure. A protocol should be established to conduct a peripheral nerve block to ensure patient safety and improve patient outcomes.