Initial presentations of frontotemporal dementia are individualized based on the disease variant being expressed; however, in later progression, there is a significant overlap between behavioral and language subsets. Being a mostly clinical diagnosis, a thorough history must be obtained from patients and families to confirm the disorder and delineate which variant is present. 

Symptoms of behavioral variant frontotemporal dementia (bvFTD) can be organized into six categories of behavioral or cognitive decline. Behavioral disinhibition featuring socially inappropriate behavior, loss of social decorum, or impulsive, careless actions are often observed. Apathy is common and is frequently misdiagnosed as depression. Loss of empathy or sympathy is characterized by a lack of interest or disregard for other's feelings. Perseverative, stereotyped, or compulsive behaviors manifest as repetitive movements, compulsive and ritualistic routines, and stereotyped speech. Hyperorality and dietary changes can include binge eating, change in preference for sweets and alcohol, and pica with oral exploration. Executive dysfunction can occur, sparing loss of episodic memory and visuospatial skills characteristic of Alzheimer's dementia. Deficits in three of these six diagnostic criteria are required for a definitive diagnosis of behavioral variant frontotemporal dementia (bvFTD).[1] 

The language variant of frontotemporal dementia known as primary progressive aphasia (PPA) is divided into three clinical syndromes, nonfluent/agrammatic primary progressive aphasia (nfvPPA), semantic variant primary progressive aphasia (svPPA), and logopenic aphasia. Clinical criteria for nfvPPA include effortful speech, speech apraxia, and agrammatism. Object knowledge and single-word comprehension are unaffected; however, complex sentence understanding may be impaired. Semantic dementia features anomia and impaired single-word comprehension. Along with these classic findings, three of the following four phenomena must be present: impaired object knowledge, surface dyslexia, and dysgraphia, spared repetition, and no disruption of speech production. Patients with logopenic variant PPA exhibit word-finding difficulty and repetition of sentences and phrases. Phonological speech errors are displayed, while single-word comprehension, object knowledge, motor speech, and simple grammar are unaffected. As with all frontotemporal dementia presentations, language variants are heterogeneous, and later stages feature overlapping symptoms as neurodegenerative pathologies spread to varied cerebral structures.[1] 

Further overlap can be seen in frontotemporal dementia-related syndromes such as motor neuron disease, corticobasal degeneration, and progressive supranuclear palsy. The ALS-parkinsonism-dementia complex has been described and demonstrates the coexistence of these motor neuron pathologies with frontotemporal dementia. Corticobasal degeneration presents with asymmetric movement impairment, and progressive supranuclear palsy features supranuclear gaze palsy with postural instability and falls. These conditions can coincide with behavioral and language deficits found in frontotemporal dementia.[1]

Imaging and fluid biomarkers are the primary focus in current and future evaluations of frontotemporal dementia. Standard, structural magnetic resonance imaging (MRI), and computed tomography (CT) modalities can demonstrate characteristic atrophy of frontal and temporal lobe grey matter.[2] At the vanguard of frontotemporal dementia imaging applications are diffuse tensor imaging for evaluating white matter integrity loss, fluorodeoxyglucose positron emission tomography (FDG-PET) to monitor localized brain metabolism, amyloid and tau PET traces which detect cerebral protein deposition, arterial spin labeling (ASL) measuring regional perfusion, and resting-state functional MRI (RS-fMRI) analyzing functional connectivity between brain structures.[2][6] 

Further studies are necessary to implement these techniques in diagnosing frontotemporal dementia, isolating which disease subset is present, differentiating between other dementia syndromes such as Alzheimer's, and longitudinal monitoring of disease progression. 

Cerebrospinal fluid and serum protein biomarkers are presently utilized to exclude Alzheimer's disease in the assessment of frontotemporal dementia and are under appraisal for prospective diagnostic indications and monitoring pathologic progression and response to potential therapies. Elevated CSF tau proteins and decreased beta-amyloid 42 protein concentrations can accurately confirm Alzheimer's dementia and are validated for eliminating frontotemporal dementia from the differential.[6]

Neurofilament light chain (NFL) proteins are increased in serum and CSF samples of patients with frontotemporal dementia and other neurodegenerative disorders and have promising applications in future frontotemporal dementia assays.[6] Gene-specific biomarkers such as progranulin and poly (GP) have the potential for investigating the expression of GRN and C9orf72 frontotemporal dementia mutations, respectively.[6] As with potential imaging techniques, more data is needed to implement fluid biomarkers into a comprehensive frontotemporal dementia evaluation strategy.

No current disease-modifying, curative therapies exist for frontotemporal dementia. Treatment must center upon symptom management with particular consideration for supportive measures for patients, families, and caregivers. There is a consensus that selective serotonin reuptake inhibitors (SSRIs) are beneficial in the management of behavioral symptoms.[1][12] Low-dose atypical antipsychotics may be implemented for aggressive or disruptive behaviors; however, caution must be advised due to black-box warning for cardiac events in the elderly.[3] Therapeutics for Alzheimer's dementia, such as cholinesterase inhibitors, are ineffective and may precipitate behavioral abnormalities in frontotemporal dementia.[3] 

Non-pharmacologic interventions have a prominent role in addressing symptoms and delaying disease progression. Physical therapy and exercise can slow cognitive decline while speech therapy may mitigate language deficits in patients with the primary progressive aphasia variants.[1] With the functional decline, patients will require assistance with activities of daily living, and a safe home environment must be secured. Formulating non-pharmacologic behavioral management strategies and implementing them consistently may assuage the physical, mental, and social burden of patient misconduct.[12]

Patient and caregiver education is paramount and can ameliorate the guilt and stigma associated with the neuropsychiatric features of the disease. Support groups and community resources must be made available to caregivers, and their psychological health should be featured in family discussions.[13] A conservatorship can be established to address financial and legal distress associated with the condition.[12]

There are abundant symptom overlaps between frontotemporal dementia and other neuropsychological disorders. Psychiatric conditions such as depression, bipolar disorder, and, most significantly, schizophrenia can mimic behavioral variant frontotemporal dementia and are often misdiagnosed during early presentations of frontotemporal disease.[5] Onset and progression patterns can assist in differentiating schizophrenia from frontotemporal dementia. While frontotemporal dementia generally occurs in patients over forty-five years-of-age, initial presentations of schizophrenia are observed in younger age groups.[5] A consistently advancing disease course characterizes frontotemporal dementia, while schizophrenia progression is variable and can plateau.[5] 

Distinguishing other dementia syndromes from frontotemporal dementia can also be challenging. A predominance of memory and visuospatial deficits suggests the more prevalent Alzheimer dementia variant. Lewy body dementia should be considered in the setting of visual hallucinations and parkinsonism.[8] 

Several miscellaneous conditions can present with neuropsychiatric and behavioral symptoms similar to frontotemporal dementia including, infections, toxins, neoplasms, trauma, paraneoplastic disease, autoimmune disorders, thyroid syndromes, hepatic encephalopathy, and various genetic pathologies.[8]

The heterogeneous nature of frontotemporal dementia, as well as its relatively low prevalence compared to Alzheimer's disease, has led to difficulty defining accurate prognosis and life-expectancy figures. Survival rates feature a wide distribution depending on the subset of phenotypes being evaluated. Patients with the motor neuron disease variant have the shortest disease course at two to three years from diagnosis to death.[9] The median life expectancy for behavioral variant frontotemporal dementia is nine years, while patients with semantic dementia have survival rates of twelve years, comparable to the generally slower progression of Alzheimer's dementia.[3][9]

The functional and cognitive decline associated with frontotemporal dementia spawn predictable somatic, psychological, and social complications for patients and their caregivers. Dysphagia is likely responsible for the increased incidence of pneumonia and respiratory failure, a significant cause of mortality in frontotemporal dementia.[13] Sequelae of swallowing difficulties include weight loss, protein-calorie malnutrition, and subsequent failure to thrive.[13][14] 

Cardiac disease, attributed to patient's sedentary and bedridden immobility status, is implicated in the most significant number of frontotemporal dementia deaths.[13][14] Gait disturbances precipitate an increased risk of falls and traumatic injury.[13]

Consultation with neurology and psychiatry are fundamental to the management of frontotemporal dementia. Geneticist evaluation may be indicated in patients with a significant family history of neurologic disorders. An interprofessional approach featuring physical and occupational therapists, dieticians, and support groups provide the comprehensive care required for patient and caregiver's physical and emotional health.[3] Palliative specialists can allay the burden for individuals and their families experiencing end-of-life transitions.[14]

Patient and caregiver education should be at the forefront of frontotemporal dementia management plans. Information regarding the disease process and progression, especially the behavioral components, can alleviate social stress and guilt associated with potential, perceived patient misconduct. Preparing families and caregivers for the physical, psychological, social, and financial toll that may follow the diagnosis can stabilize the care environment and promote the overall effectiveness of the care team.

The heterogeneous nature of frontotemporal dementia, along with its insidious onset, precipitous decline pattern, and substantial impact on patients and caregiver's lives necessitates a comprehensive diagnostic, management, and educational care plan. Interprofessional cooperation and communication are imperative to shape a capable healthcare team and to minimize the physical, mental, and emotional burden of the disorder. A patient-centered medical home model comprised of a primary clinician coordinating care between neurologists, psychiatrists, geneticists, physical, occupational, and speech therapists, dieticians, nurses, home health workers, palliative specialists, support groups, and community resources are essential to improving the quality of life of all involved. [Level 5]

The exponentially increased emphasis on frontotemporal dementia genetic and molecular pathologies research over the last several years has led to hopeful optimism for new, targeted, disease-modifying therapies, imaging technologies, and chemical biomarkers to expand our armamentarium to combat frontotemporal dementia. [Level 5]