Exposure to birds or occupational exposure is the most important clue in the patient's history. C. psittaci commonly presents in young to middle-aged males who complain of fever (most common symptom), chills, headache, myalgia, and dry cough. Symptoms vary from mild to severe systemic disease. In systemic involvement, the patient may present with hepatosplenomegaly and gastrointestinal symptoms. Endocarditis and myocarditis have also been described, and a minimal percentage of patients present with altered mental status. The incubation period is usually 5 to 19 days but can be as long as 28 days. In the pre-antibiotic era, fatal cases were common. Today, imported bird quarantine, treatment, and improved hygiene measures have rendered psittacosis cases rare.[1]

Pulmonary symptoms include a dry cough, and lung auscultation during physical exam may reveal rales or rhonchi. Uncommonly, a pleural rub may be appreciated. A pulse-temperature dissociation (fever and relative bradycardia) has been described for psittacosis pneumonia. Patients may also show signs of photophobia, epistaxis, tinnitus, deafness, gastrointestinal symptoms, and arthralgia if systemically compromised.

The best method for confirming C. psittacosis infection is with serologic testing, namely micro-immunofluorescent antibody test (MIF). Cultures are highly discouraged due to being difficult, infectious to lab personnel, and only performed in specialized labs. MIF testing uses chlamydia-specific surface antigen. A test result with antibodies above 1:16 is considered evidence for exposure, while a 4-fold titer rise with clinical correlation is considered diagnostic. Complement fixation (CF) was the previously diagnostic test of choice, but it cannot differentiate between chlamydial species.[3]

If obtained, laboratory testing may evidence a normal white blood cell count with a "left shift." Erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) may be elevated. If a systemic illness is present, the patient may evidence abnormal liver enzymes, hyponatremia, and elevated BUN/creatinine.[5]

Chest radiographs most often show single lower lobar changes. Computed tomography has higher sensitivity and may reveal nodular pulmonary infiltrates with surrounding ground-glass opacities.

The primary treatment for C. psittaci consists of tetracyclines. Tetracycline 500 mg by mouth (PO) 4 times per day or doxycycline 100 mg PO or intravenously (IV) 2 times per day are described as a treatment of choice for 7 to 10 days. Minocycline 100 mg PO or IV 2 times per day may also be effective. Macrolides are second-line agents. Azithromycin 250 to 500 mg PO once daily is favored over erythromycin. Macrolides are the treatment of choice for children.[1]

The initial signs and symptoms of C. psittaci, including fever, headache, and dry cough, can lead to a very broad differential diagnosis. Other culprits of atypical pneumonia, such as Chlamydia pneumoniae, mycoplasma infections, Legionnaires' disease, Q fever, and Tularemia, may be considered when presenting with C. psittacosis. Patients presenting only with fever have a broader differential that includes influenza, septicemia, endocarditis, other causes of pneumonia (bacterial and fungal), and other sources of infection. History of exposure to birds or bird droppings, as might be found under bridges, should raise psittacosis on the differential diagnosis.

Recent studies have shown that C. psittaci copes better than other chlamydial strains with the host's pro-inflammatory effectors during early immune response.[6] In a recent case study,[7] a nested PCR of a nasopharyngeal swab of a patient and feces of his pet parakeet confirmed C. psittaci infection when serology was negative, pointing to a possible need for broader implementation of PCR for early diagnosis. C. psittaci has also been found in non-avian hosts, although its clinical importance to humans has not been proven.[6]

Prognosis for C. psittacosis depends largely on the patient's baseline health status, the severity of disease, and early diagnosis and treatment. Full recovery may take from 6 to 8 weeks, including residual changes on chest films. Per the CDC, the current mortality rate in the United States is less than 1% with early diagnosis and appropriate treatment.[3]

Apart from pneumonia and its pulmonary complications, systemic infection with C. psittaci can lead to endocarditis, hepatitis, and encephalitis.[1]

Psittacosis pneumonia, better known as parrot fever or ornithosis, is an infection caused by birds. Infection usually presents with sudden fever, headache, body aches, and a dry cough. People at increased risk are pet bird owners, pet shop workers, veterinarians, and poultry processing plant workers. In severe cases, C. psittaci can infect other organs including the kidneys, liver, and central nervous system. Given the potentially fatal nature of this disease, antibiotics should be started as soon as possible and continued for 7 to 10 days. Per the CDC, only buy pet birds from a well-known pet store. If you own pet birds or poultry, follow good hygiene precautions when handling and cleaning birds and cages.[1]

• Psittacosis pneumonia is a zoonotic infection caused by contact with birds infected by C. psittaci.
• Infection is caused by inhalation (including transient) of aerosolized particles from dried feces, respiratory secretions, bird bites, and feather dust.
• C. psittaci usually presents in young to middle-aged adults as a sudden fever with pulse-temperature dissociation, headache, myalgia, and dry cough. The physical exam may be remarkable for rales and rarely a pleural rub. Chest radiography may show single lobe changes, although multi-lobar changes are also possible. 
• Infection may manifest with systemic involvement such as respiratory failure, endocarditis, myocarditis, encephalopathy, and/or hepatitis.
• Diagnosis is usually established clinically with the presence of fever, headache, dry cough, lobar changes on chest radiography, and recent exposure to birds- treatment should be initiated when suspected.
• Serologic testing is the gold standard for diagnosis. Cultures are highly discouraged and are only performed in specialized labs.
• Tetracyclines are first-line therapy. Tetracycline (500 mg PO 4 times per day) or doxycycline (100 mg PO or IV 2 times per day) for 7 to 10 days are recommended. Macrolides are second-line therapy, especially for children and pregnant women.

Pneumonia due to infection with C. psittaci is a very rare disease worldwide (less than 1% of all CAP cases) that can present with common symptoms.[3] (Level I) Adequate history taking and physical exam must be performed at all levels of care to achieve early diagnosis and treatment. Given the zoonotic nature of this disease and the potential for an outbreak, it is important to coordinate with the appropriate public health and veterinary officials for adequate quarantine of infected birds and avoid the spread of disease.[8] (Level I) Physicians, physician assistants, nurse practitioners, and pharmacists must work together to provide appropriate patient education and coordinate care for the best outcome.