Early retropharyngeal abscess presents similarly to uncomplicated pharyngitis. Aspects of a patient's history that are concerning for early retropharyngeal abscess would be antecedent upper respiratory tract infection or trauma to the posterior pharynx. As this infection progresses, symptoms related to upper aerodigestive obstruction become more prominent and typically progress over days. The following are red flags in a patient’s history which should be concerning for upper aerodigestive obstruction:

• Dysphagia
• Odynophagia
• Inability to tolerate oral secretions
• Neck stiffness
• Torticollis
• Refusal to extend neck due to pain or discomfort
• Change in voice, “hot potato voice,” muffled voice
• Trismus
• Neck swelling, cervical lymphadenopathy
• Chest pain (mediastinal extension)
• Respiratory distress (stridor, tachypnea, retractions).

Patients who present with retropharyngeal abscess typically are febrile and ill-appearing. Early in the illness, patients may only have mild to moderate pharyngeal erythema and refusal to tolerate anything by mouth. As the disease progresses, pharyngeal erythema and swelling will become more prominent, and patients will be unable to tolerate even their oral secretions. Patients typically will have extreme discomfort with neck extension and often will prefer to hold their necks in flexion, as opposed to epiglottitis, where patients will preferentially hold their necks in extension.

The oropharynx of a patient with a suspected retropharyngeal abscess only should be thoroughly examined with palpation or probing by clinicians who are experienced in emergent airway management. Abscess rupture can occur during the examination of the posterior pharynx, leading to aspiration and potential asphyxiation. It has been suggested that this exam should be performed with patients in the Trendelenburg position to prevent aspiration in case of abscess rupture, and suction equipment should be readily available.

Labs, including complete blood count, blood cultures, and preoperative labs, are necessary if a retropharyngeal abscess is suspected. However, obtaining these labs should be delayed if phlebotomy will cause additional distress to the patient. This additional distress to the patient can cause early upper airway obstruction to become complete upper airway obstruction, especially in younger children. Both aerobic and anaerobic blood cultures should be obtained. In patients with retropharyngeal abscess, white blood cell counts are greater than 12,000 in 91% of individuals.[3][10][11]

Lateral neck radiographs are typically the imaging study of choice in the initial evaluation of suspected retropharyngeal abscess, especially in young children. Lateral neck radiographs have the benefit of lower radiation exposure and tend to be better tolerated by patients who are exhibiting signs of airway compromise. Lateral neck x-rays should be obtained during inspiration with the neck held in normal extension. Improper technique in obtaining this imaging study can result in false positives for retropharyngeal infection.  When the retropharyngeal infection is present, the depth of the prevertebral space will be increased on the lateral neck x-ray. In healthy individuals, the upper limit of normal of the prevertebral space is 7 mm at C2 and 14 mm at C6 in children. In healthy adults, the upper limit of normal of the prevertebral space is 7 mm at C2 and 2 mm at C6. A width of 30 mm at C6 indicates abscess collection.

Additionally, patients who are presenting with a concerning story for retropharyngeal abscess, which is also reporting chest pain, should have a chest x-ray obtained to investigate for mediastinal involvement.

CT of the neck with intravenous contrast is the best imaging study to evaluate patients with a retropharyngeal abscess. If there is a concern for airway compromise in these patients, a clinician who is trained in emergency airway management should be present while the CT scan is being obtained. Patients may require an emergent surgical airway if upper airway obstruction occurs. The sensitivity of CT scan for detecting retropharyngeal abscess varies in the literature ranging from 64% to 100%.

In children, ultrasound is preferred as it does not involve radiation and is portable. In experienced hands, ultrasound can help determine the size and location of the abscess.

All patients presenting with a confirmed diagnosis of retropharyngeal infection require hospital admission, intravenous antibiotics, and otolaryngology consultation. Antibiotic therapy should cover upper respiratory organisms, including anaerobic organisms. Patients presenting airway compromise should have immediate surgical incision and drainage performed to relieve their upper airway obstruction.[12][13][14]

In patients not presenting with severe respiratory distress or airway compromise, management typically begins with a 24 to 48 hour trial of intravenous antibiotic therapy. After 24 to 48 hours of antibiotic therapy, the need for surgical incision and drainage will be reevaluated by a trained otolaryngologist. Factors that have been associated with an increased need for surgical incision and drainage include an abscess with a cross-sectional area greater than 2 cm2 and symptoms for greater than two days. There is no evidence that patients presenting with mature abscesses greater than 3 cm2 benefit from surgical intervention before 24 to 48 hours of antibiotic therapy.

All patients must have careful airway monitoring when undergoing treatment of retropharyngeal abscess, especially during the first 24 to 48 hours of therapy.

Initial antibiotic therapy should include either ampicillin-sulbactam (50 mg/kg every 6 hours) or clindamycin (15 mg/kg every 8 hours). If patients appear septic or do not respond to initial antibiotic therapy, vancomycin or linezolid also should be administered. Parenteral antibiotics should be continued until patients are clinically improved and afebrile for 24 hours. After patients demonstrate clinical improvement and remain afebrile, they may be transitioned to oral antibiotics. Amoxicillin-clavulanate (45 mg/kg every 12 hours) or clindamycin (13 mg/kg every 8 hours) are acceptable oral regimens. Oral antibiotics should be prescribed for 14 days, and the patient may be discharged home with strict return precautions.

• Foreign body in airways
• Pneumonia
• Mediastinitis
• Epidural abscess
• Oral cavity infections
• Epiglottitis
• Pharyngitis

• Airway obstruction
• Bronchial erosion
• Mediastinitis
• Sepsis
• Acute respiratory distress syndrome
• Cranial nerve palsies
• Esophageal perforation
• Erosion into carotid artery or jugular vein
• Meningoencephalitis

After surgery, patients should be kept NPO until all signs of the abscess have subsided. Close monitoring of the patient is required in an ICU setting. Most patients need prolonged antibiotics and total parenteral nutrition for 4-6 weeks.

• Otolaryngologist
• Dental surgeon
• Anesthesia
• Critical care specialist

• Maintain good oral hygiene
• Regular dental checkups

Retropharyngeal abscess is a life-threatening disorder that can quickly result in airway compromise and death. In view of the very high morbidity and mortality, an interprofessional team approach to diagnosis and treatment is recommended.

The interprofessional team responsibilities include the following:

The triage nurse should be familiar with the symptoms and not mistake it for a simple upper respiratory tract infection. All patients appearing toxic should be admitted, and the emergency department physician is notified.

The emergency department physician should refrain from performing an oral exam because it may lead to irritation of the upper airways and dyspnea. If the patient is toxic, both the otolaryngologist and anesthesiologist should be notified in case an emergent airway is required.

The radiologist should be consulted for the appropriate imaging test to determine the location and extent of the abscess.

The patient should be monitored by the critical care specialist, thoracic, and otolaryngologist.

The patient needs close monitoring of the vitals, oxygenation, and ventilation by the nurses. Any deviation from normal parameters should be immediately communicated to the interprofessional team because the risk of airway compromise is high. In addition, most patients are not able to eat for weeks or months, and thus, a dietary consult for TPN should be ordered.

Most patients need extensive rehabilitation to regain muscle strength, joint movement, and speech. For those who undergo a tracheostomy, respiratory therapy follow up is necessary for teaching the patient about tracheal care and the process of weaning.

Besides delivering ICU care, the nurse also plays a vital role in patient and family education. In order to prevent the disorder, the patient should be educated on proper maintenance of oral hygiene and getting regular dental checkups. More importantly, the patient should be told that he or she has symptoms of dysphagia or dyspnea and a fever, immediate medical care should be sought. Way too many people delay seeking medical care, thinking that they only have a URTI. Finally, the pharmacist should instruct the patient to discontinue smoking, eat healthily, maintain a healthy weight, and abstain from alcohol. [15][16][17] [Level 3]

Outcomes

When the diagnosis is made early and treatment instituted, the prognosis is good. But the patient needs aggressive treatment, preferably in the ICU. If there is any delay in treatment, complications are common, and the disorder carries a mortality rate of over 40%.[2][18] [Level 5]