Lopinavir/ritonavir is a combination drug used for HIV. The small amount of ritonavir increases the bioavailability of the lopinavir.[1] The standard route of administration is oral. It comes as a tablet, soft gel capsule or an oral suspension, both for adult and pediatric population.[2] The typical regimen is 400 mg/100 mg orally twice per day or (400/100 mg)/5 mL oral solution.
Adults:
Tablet:
100 mg/25 mg
200 mg/50 mg
Oral solution:
(400 mg/100 mg)/5 mL
HIV-1:
400 mg/100 mg orally twice daily, or
800 mg/200 mg by mouth daily in patients with less than three lopinavir resistance-associated substitutions
Increase the dose to 500 mg/125 mg orally twice daily or 520 mg/130 mg solution by mouth twice daily if used with efavirenz, fosamprenavir, nelfinavir, or nevirapine.
Pregnant patients:
400 mg/100 mg oral dosing twice daily
Increase the dose to 500 mg/125 mg orally twice daily when used with efavirenz, fosamprenavir, nelfinavir, or nevirapine.
HIV post-exposure prophylaxis:
400 mg/100 mg orally twice daily
Pediatrics:
HIV infection:
(14 days- 12 months):
16 mg/4 mg/kg orally twice daily
Treatment naïve patients, age over 13 months, less than 15 kg:
12 mg/3 mg/kg orally twice daily or 230 mg/57.5mg/m^2
Increase the dose to 300 mg/75 mg/m^2 when used with efavirenz, fosamprenavir, nelfinavir, or nevirapine.
Treatment naïve patients, greater than 13 months, 15 to 40 kg:
10mg/2.5 mg/kg by mouth twice daily OR 230 mg/57.5 mg/m^2
Increase the dose to 300 mg/75 mg/m^2 when used with efavirenz, fosamprenavir, nelfinavir, or nevirapine.
Treatment-experienced patients, older than 13 months, under 15 kg:
13 mg/3.25 mg/kg orally twice a day. Max dose is 400 mg/100 mg twice daily or 300 mg/75 mg/m^2
Increase the dose to 300 mg/75 mg/m^2 when used with efavirenz, fosamprenavir, nelfinavir or nevirapine
Treatment-experienced patients, over 13 months, 15 to 45 kg:
11 mg/2.75 mg/kg by mouth two times daily. Max dose is 400 mg/100 mg twice daily or 300 mg/75 mg/m^2
Increase the dose to 300 mg/75 mg/m^2 when used with efavirenz, fosamprenavir, nelfinavir, or nevirapine.
Treatment experienced patients, older than 13 months, weight greater than 45 kg:
400 mg/100 mg/kg orally twice daily
Increase to 500 mg/125 mg orally twice daily or 520 mg/130 mg solution twice per day with efavirenz, fosamprenavir, nelfinavir, or nevirapine.