The superficial peroneal nerve supplies motor innervation to the following muscles:

• Peroneus longus muscle
• Peroneus brevis muscle

Anatomic variations of deep (crural) fascia piercings have been widely identified for the superficial peroneal nerve.[10][11][12] It appears that the superficial peroneal nerve pierces the crural fascia as a single nerve then bifurcates into the medial dorsal cutaneous nerve and intermediate dorsal cutaneous nerve as described above approximately 82.7% of the time known as the Type 1 variant.[10] However, approximately 15.6% of the time, it appears that the superficial peroneal nerve bifurcates early, therefore piercing the fascial layer as the medial dorsal cutaneous nerve and intermediate dorsal cutaneous nerve separately. This anomaly is known as the Type 2 variant.[10] Moreover, 1.8% of the time, there is documentation of a Type 3 variant in which the superficial peroneal nerve pierces the fascial layer as a single entity and continues as the normal course for the medial dorsal cutaneous nerve without evidence for an intermediate dorsal cutaneous nerve.[10]

In addition to variation in fascial layer piercings, the superficial peroneal nerve has also been shown to be located in various compartments of the leg rather than the normal lateral leg compartment. According to one study in India, 28.3% of cadaveric specimens were found to have the superficial peroneal nerve located in the anterior compartment.[11]

The superficial peroneal nerve is the only nerve that can be visualized in the human body without dissection by simply plantar flexing, inverting the ankle, and examining the dorsum of the foot.[13][14][15]Despite its straightforward visualization, damage to the superficial peroneal nerve is the most commonly reported complication when performing ankle arthroscopy likely resulting from the fact that anterior ankle arthroscopy is typically performed in the neutral or slightly dorsiflexed position rather than the plantarflexed and inverted position.[14] Complication rates as high as approximately 17% have been reported, with more than 25% of those complications related to superficial peroneal nerve damage.[13] The recommendation is to visualize the nerve first and mark its course on the skin preoperatively to avoid damage.[14][16]

It is important to consider the anatomic variations of the superficial peroneal nerve and its branches as the branch most commonly at risk for iatrogenic injury is the intermediate dorsal cutaneous nerve when it courses near the distal fibula and both the medial and intermediate dorsal cutaneous nerves at the level of the ankle.[12]

When the superficial peroneal nerve is injured, one will lose the ability to evert the foot based upon the motor mechanics of the nerve.[1] The dorsum of the foot will exhibit loss of sensation (excepting the first webspace between the great toe and second toe where the deep fibular nerve provides sensory innervation).[1][4] The nerve damage pattern can accompany damage directly to the common peroneal nerve which frequently occurs due to a blow to the lateral side of the knee or a fracture to the fibular head.[1][3] The superficial peroneal nerve can also become trapped, and this can result in pain and paresthesias over the lower leg as well as the dorsum of the foot. Entrapment of the nerve can be secondary to an ankle sprain or twisting injury to the ankle which causes the nerve to stretch in the lower leg or foot.[17] Additionally, the nerve can also become entrapped by the fascia in a patient with either acute or chronic compartment syndrome resulting in reduced blow flow and oxygen delivery to the nerve. Surgical decompression is required to provide relief from pain and other symptoms especially in the acute setting.[18]