Functionally, the respiratory tract consists of the conducting airways, extending from the nose down to the terminal bronchioles, and the gas-exchanging airways, which extend from the respiratory bronchioles to the alveoli within the lungs. Dead space refers to the portions of the lungs that fill with air but do not participate in gas exchange. The primary determinant of dead space is the anatomical dead space, which refers to air in the conducting airways. Alveolar dead space, on the other hand, refers to alveoli that fill with air but do not participate in gas exchange. It constitutes a minor contributor to dead space. Together, the anatomical and alveolar dead space form the physiological dead space, which represents the total amount of air in the lungs that does not participate in gas exchange.

Tidal volume is essentially every breath a person takes. It is one of the main determinants of minute ventilation and alveolar ventilation. Minute ventilation, also known as total ventilation, is a measurement of the amount of air that enters the lungs per minute. It is the product of respiratory rate and tidal volume. Alveolar ventilation, on the other hand, takes physiological dead space into account. It represents the volume of air that reaches the respiratory zone per minute.

• Minute ventilation = respiratory rate x tidal volume

• Alveolar ventilation = respiratory rate x (tidal volume - dead space)

Since alveolar ventilation considers dead space, it represents actual ventilation. Generally, there is an equal contribution from tidal volume and respiratory rate to minute ventilation. In other words, doubling either of them produces the same increase in minute ventilation. When it comes to alveolar ventilation, though, increasing tidal volume is a more efficient way than increasing respiratory rate. As such, doubling tidal volume improves alveolar ventilation more than doubling the respiratory rate does. The concept proves relevant when it comes to patients with hypercapnia. Hypercapnia induces a breathing pattern characterized by a relatively larger increase in tidal volume than the respiratory rate to minimize dead space ventilation. In other terms, Hypercapnic patients compensate by taking slow, deep breaths to optimize CO2 elimination. The only way to minimize dead space ventilation is to increase the volume of air that reaches the respiratory zone, which can only be done by increasing tidal volume.[6]

Air moves in and out of the lungs through movements of the diaphragm and the chest wall. The diaphragm is the primary muscle of inspiration and is the one that contributes the most to tidal volumes. When the diaphragm contracts, the thoracic cavity expands vertically. As a result, intrapleural pressure decreases from -5 cm H2O to around -8 cm H2O. Since the lungs are connected to the chest wall via the pleura, the negative intrapleural pressure pulls the lungs towards the chest wall leading to an increase in lung volume. As lung volume increases, pressure decreases as per Boyle's law. The resulting sub-atmospheric intra-alveolar pressure then draws air into the alveoli based on the pressure difference. Once the pressure equalized, a tidal volume of approximately 500 mL is delivered.

In contrast, expiration is generally a passive process that occurs due to the lungs' elastic properties once the diaphragm relaxes. Relaxation of the diaphragm causes the rib cage to move closer to the lungs leading to an increase in intrapleural pressure back to -5 cm H2o. As a result, lung volume decreases, and pressure becomes higher than atmospheric pressure. This forces air out of the lungs as per pressure difference and the lungs get back to their resting state.

Tidal Volume During Sleep

Sleep alters respiratory physiology in various ways. REM sleep, in particular, is the sleep phase with the highest degree of breathing irregularity, both in frequency and respiratory rate. During REM, almost all body muscles, including respiratory muscles, become hypotonic, except for the diaphragm. Therefore, a person relies on the diaphragm to maintain an adequate tidal volume during REM. Additionally, respiratory response to hypoxic and hypercapnic stimuli decreases, not to mention the decreased central respiratory drive, which, along with accessory muscle paralysis, leads to a slight decrease in tidal volume and minute ventilation. The change is usually not prominent in healthy individuals but becomes prominent in patients with preexisting respiratory disease.[7]

Physiologically, lung volumes can be either dynamic or static. Dynamic lung volumes are, by definition, dependent on airflow rate. In contrast, static lung volumes are not affected by the flow velocity. A variety of lung pathologies induce changes in lung volumes. Therefore, pulmonary function testing provides valuable diagnostic information since it helps measure various lung volumes and capacities.

Spirometry is a crucial test used by pulmonologists to diagnose restrictive and obstructive pulmonary diseases. It measures how air flows in and out of the lungs and records several lung volumes and lung capacities. During spirometry, the patient takes a normal breath, followed by a full inhalation, a maximum forced exhalation, and then another normal tidal breath.

Tidal volume is a static lung volume that, along with other static and dynamic lung volumes, is important for the diagnosis of patients with obstructive and restrictive lung diseases. Spirometry records tidal volume while the patient breathes quietly. In healthy adults, it measures approximately 7 mL/kg of ideal body weight. In an average healthy adult, 500 mL enters the lung with each tidal breath, of which only 350 mL reaches the respiratory zone since dead space measures approximately 150 mL.[5]

Restrictive Lung Diseases

Restrictive lung diseases are a group of chronic pulmonary conditions characterized by the inability of the lungs to fully expand, owing to problems in the lungs themselves or the structures surrounding them. Interstitial lung diseases, such as idiopathic pulmonary fibrosis and asbestosis, cause progressive fibrosis of the lung tissue. As such, they represent an intrinsic lung pathology that leads to a restrive physiology due to increased stiffness and decreased compliance. Morbid obesity and sarcoidosis are examples of extrinsic problems that cause restriction by limiting chest wall expansion. In restrictive lung disease, the patient adapts a breathing pattern of rapid, shallow breaths to minimize the work of breathing.

Obstructive Lung Diseases

The hallmark of obstructive lung disease is difficulty expelling air out of the lungs due to progressive airway narrowing. Chronic obstructive pulmonary disease (COPD) and asthma are the two typical examples of obstructive lung disease. Asthma is a reversible condition characterized by airway hyperresponsiveness to various stimuli. It causes episodes of excessive mucous production, bronchoconstriction, and airway narrowing. On the other hand, COPD is an irreversible chronic inflammatory process that leads to a gradual reduction in the lumen of the conducting airways. As the condition progresses, air-trapping ensues, leading to lung hyperinflation. Since the problem in obstructive lung disease is expiratory, breathing with higher tidal volumes helps overcome airway resistance. Therefore, patients acquire a breathing pattern of deep, slow breaths to minimize the work of breathing.

Mechanical Ventilation

Acute respiratory distress syndrome, or ARDS, is a condition characterized by widespread inflammation of the lungs following an inciting pulmonary or extrapulmonary event. ARDS usually causes hypoxemic respiratory failure or critically low arterial oxygen tension necessitating mechanical ventilation. Patients with ARDS already have injured lungs, and mechanical ventilation should follow a lung-protective strategy. In other terms, tidal volumes should be kept as low as possible to prevent volutrauma and barotrauma. The problem in ARDS is that pulmonary edema and distal airway collapse decrease the surface area of the aerated lungs. Therefore, ventilation with large or even regular tidal volumes may cause hyperinflation of the healthy aerated portion of the lungs since air does not reach the already collapsed airways. As a result, alveolar overdistension and lung injury might occur. Generally, lung-protective strategies in patients with ARDS involve administering tidal volumes of approximately 6-8 mL/Kg of ideal body weight.[8][9]

Neuromuscular Disease

Neuromuscular diseases refer to a group of disorders characterized by progressive muscle weakness due to problems in the muscles themselves or the nerves that supply them. Patients with neuromuscular diseases (NMDs) eventually develop respiratory muscle weakness. The diaphragm is the primary muscle of inspiration and is the one most commonly affected in NMDs. Patients with a weak diaphragm rely on other muscles of inspiration, such as the external intercostals, to maintain adequate tidal volume. During REM sleep, there is generalized hypotonia of all respiratory muscles, except for the diaphragm, and a healthy person becomes diaphragm dependent. In patients with NMDs, dyspnea becomes prominent at night due to diaphragmatic weakness. Nocturnal REM-related hypoventilation is one of the earliest signs of respiratory muscle involvement in neuromuscular disease. As the disease progresses, daytime symptoms become prominent, and patients rely on a breathing pattern similar to the one seen in other restrictive lung diseases, i.e., shallow, rapid breathing.[10][11]