A detailed patient history and clinical examination are the most important factors for an accurate diagnosis of ATTS.

Patients will typically complain of sharp shooting pain, numbness, or tingling along the distribution of the DPN or its terminal branches. Symptoms are typically intermittent and exacerbated by physical activity and alleviated by rest and elevated. The most common location of symptoms is the dorsal forefoot, more specifically the distal dorsal first webspace. The patient may recall a history of acute trauma (ankle sprain or hyper-plantar flexion injury) or repetitive microtrauma (runner or military trainee). On physical exam, repetitive percussion of the DPN may reproduce radiating paresthesias in the distal (Tinnel sign) or proximal (Valleix sign) directions. Palpation of the ankle may reveal edema or a space-occupying lesion (varicose vein or ganglion), while palpation of the foot may reveal palpable dorsal osteophytes (bone spurs). Extreme active or passive plantar flexion of the ankle may reproduce the patients' symptoms due to a stretching/compression of the nerve. A pes cavus (high arch) foot type can be present on the exam, which can contribute to dorsal compressive forces and abnormal fitting of shoe-gear.

A full lower extremity musculoskeletal and neurologic exam should be performed, including muscle strength, vibratory, light touch, temperature, and two-point discrimination exams. 

In a small case series of 13 patients, Yasin et al. reported that Tinel sign was positive in 100% of patients, and a palpable bulge in anterior ankle or foot was present in 92% of ATTS cases.[15]

There is no specific test to diagnose anterior tarsal tunnel syndrome, and diagnosis is primarily from a comprehensive history and physical examination with additional imaging as needed based on physician preference. 

Blood work to rule out diabetes should be done. Some men with reactive arthritis may develop this disorder and be positive for HLA B27. In addition, systemic arthritic disorders should be ruled out by ordering ESR, antinuclear antibody, and rheumatoid factor.

Weight-bearing radiographs of the foot and ankle are a simple, inexpensive, and readily available test that can aid in identifying overall foot-type (pes cavus) or bone spurs that may be contributing to the compression neuropathy.

In questionable clinical scenarios, nerve conduction velocity and electromyography tests may be ordered to confirm the diagnosis of ATTS and the location of the DPN entrapment. Nerve conduction studies will show deep peroneal nerve distal latency, and EMG will demonstrate findings only in the EDB muscle belly.[13]

If a soft tissue mass (ganglion or varicosities) are present on the physical exam, an MRI is an option. MR neurography is another imaging modality proven useful in diagnosing lower extremity entrapment neuropathies.[16]

High-resolution musculoskeletal ultrasound imaging is also a recommendation as electrophysiologic studies are not always reliable due to variability in peripheral nerves.[17] 

The treatment of ATTS is based on the underlying etiology. Treatment should begin with a trial of non-operative methods such as:

• Changes to footwear and shoe-lacing technique modification
• Biomechanical modifications such as over-the-counter orthotics, custom orthotics, or padding 
• Topical anti-inflammatory or compound creams
• Oral or topical NSAIDs or neuropathic pain medications such as gabapentin
• Perineural corticosteroid/anesthetic injection at the site of nerve entrapment
• Compression socks to alleviate local edema or varicosities
• A period of decreased athletic activity or immobilization via CAM boot

Surgical options should only be presented after failing a period of non-operative treatment. Surgery is based on the underlying etiology and may include:

• Release or decompression of the extensor retinaculum and any surrounding scar tissue
• Excision of space-occupying lesions (ganglion, varicose veins)
• Resection of osteophytes (bone spurs)
• Neurolysis, nerve wrapping, resection of neuroma or neurectomy of the DPN

Surgery is most commonly performed via an open approach; however, minimally invasive endoscopic approaches are also viable options.[18][19][15]

In each surgical case, the retinaculum must be identified, and the posterior tibial nerve visualized. One should avoid injuring branches of the nerve and carefully release the fibrous bands.

Differential diagnosis of ATTS includes other conditions which can cause distal paresthesias including[20]:

• Exertional anterior compartment syndrome
• Common peroneal nerve entrapment
• Superficial peroneal nerve entrapment
• 1st inter-space neuromas (Heuter's neuroma)
• Lumbosacral radiculopathy
• Inflammatory disease states
• Primary nerve tumor
• Mid-foot retinaculum entrapment mimicking ATTS

Peripheral nerve injuries are primarily classified by the Seddon or Sunderland classification systems, which also correlate histology, MRI/Clinical presentation, and recovery.[21][22]

The prognosis of an anterior tarsal tunnel is variable; however, most case reports/series demonstrate good to excellent results with surgical intervention.

• Yassin et al. reported 12 out of 13 patients described their condition as greatly improved after surgery.[15] 
• Dellon published a case series of 18 patients who had surgical decompression of the DPN. After a 25.9 month follow-up period, they reported 60% excellent results, 20% good results, and 20% no improvement.[23]
• Murphy performed 21 surgeries on 15 runners with persistent peripheral nerve injuries in the foot and ankle pain. He reported, 100% good to excellent results, and stated all patients returned to their pre-injury running status, including competitive athletes.[24]

Anterior tarsal tunnel syndrome that is left untreated can result in persistent pain or neuropathies of the deep peroneal nerve or its branches. 

Surgical complications after decompression include nerve injury or extensor hallucis brevis wasting in the late-stage presentation.[14] Additional postoperative risks include infection, wound dehiscence, scar tissue formation, failure to resolve pain/original symptoms, and the need for additional/revisional surgery.

In the initial 1 to 3 weeks after surgery, postoperative care focuses on immobilization and incision healing as surgery in the anterior ankle can be problematic in terms of wound dehiscence. Next, the patient should start a formal physical therapy or at-home program to enhance the strength and range of motion while decreasing edema, pain, scar tissue, and irritation of the nerve. The patient will eventually return to normal gait and athletic activities. 

• Podiatrist or podiatric surgeon
• Orthopedic surgeon
• Physical therapist
• Radiologist
• Neurologist or physiatrist
• Orthopedic nursing

No guidelines for the prevention or deterrence of anterior tarsal tunnel syndrome exist. Anecdotally, one can avoid or loosen tight-fitting shoes or athletic gear.

There is a magnitude of causes of foot and ankle pain, some of which are rare, including anterior tarsal tunnel syndrome. If a patient is experiencing foot or ankle pain with or without symptoms such as burning, numbness, tingling, and muscle weakness, they should seek the care of a medical professional.

• The anterior tarsal tunnel is an entrapment neuropathy of the deep peroneal nerve or its terminal branches in the anterior ankle.
• It is relatively uncommon and often misdiagnosed.
• The etiology includes any form of compression on the DPN, typically caused by the inferior extensor retinaculum or osteophytes in the dorsal foot.
• Patients may have pain and paresthesia originating from the site of entrapment and radiating down to the dorsal foot, specifically the first webspace.
• There is no specific test to diagnose anterior tarsal tunnel syndrome, and diagnosis relies on a combination of a thorough history, physical exam, imaging, and electromyography and nerve conduction studies.
• Conservative treatment should be attempted in all patients before surgical decompression.
• Be aware of the existence of an accessory deep peroneal nerve derived from the superficial peroneal nerve.

Anterior tarsal tunnel syndrome is a relatively rare condition that is mainly treated by podiatrists, orthopedic surgeons, and physical therapists. If surgery is the chosen therapeutic course, then other healthcare providers will join the team, such as perioperative nurses, anesthesia staff, and pharmacists. The literature is scarce, with only citations of level V case reports.  

The nurses assist with coordination of care and followup. They should also assist the interprofessional team in providing patient and family education. The pharmacist should assist with providing medication reconciliation and the success of pain medication. Both the foot and nail care nurse and pharmacist should work with the clinician in making sure pain is relieved while avoiding opioid addiction. Patients may experience side effects of medications used to relieve pain, and the interprofessional team should work together to identify these side effects and offer viable alternatives. The best outcomes are achieved by a coordinated interprofessional team effort to evaluate and treat patients with anterior tarsal tunnel syndrome. [Level V]