Many patients turn to injections for their CTS when conservative therapies fail. Corticosteroid solutions are the predominant injectate used. Controversy exists over the safest injection site. A comparative study of several locations found that injecting within the flexor carpi radialis tendon proximal to the carpal tunnel might be the safest.[9] The in-plane ulnar approach has been shown to be superior to the proximal approach for improving symptom severity.[10]

The patient may be seated or supine during the injection. The affected wrist is supinated in slight dorsiflexion using a rolled-up towel and taping the fingers down. An ultrasound linear array probe can be used to scan the wrist for any anatomical variants such as volar ganglion cysts, flexor tendon tenosynovitis, and tumors.[11] The probe is then placed transversely at the proximal wrist crease by the entrance to the carpal tunnel. The goal is to have the pisiform, ulnar nerve, and ulnar artery in view as well as the median nerve. Doppler imaging can aid in determining vascular structures. The median nerve is identified and most often edematous. The injectate is targeted around the nerve in a target sign. The subsynovial tissue may also be injected, which has recently been implicated as the etiology of idiopathic CTS.[12]

Using sterile technique, the needle is introduced most commonly on the ulnar aspect of the carpal tunnel. The initial trajectory is shallow and superficial to the ulnar artery and nerve penetrating the flexor retinaculum.[13] The anterior aspect of the medial side of the nerve is injected first. The nerve should separate from the flexor retinaculum located anteriorly. This hydrodissection should reduce any adhesions, which may have caused entrapment. The needle is then redirected deeper on the ulnar side to inject the posterior aspect. The nerve should be completely surrounded by the injectate and “floating” in the solution.

Studies have shown that 75% of corticosteroid injections were accurately placed solely using landmarks, while 8.7% penetrated and damaged the median nerve.[14] Ultrasound guidance has been proven to reduce adverse events significantly. Meta-analysis also showed significant improvement in CTS severity using ultrasound guidance in 12 weeks compared to landmark-guided injections.[15]

Platelet-rich plasma (PRP) injections have recently risen as a new modality for long-lasting pain relief. PRP contains concentrated platelets and growth factors that have been shown to alleviate CTS symptomatology. PRP promotes axonal regeneration, thereby restoring the function of the median nerve. A systemic review of five studies, including three randomized controlled trials, one case-control, and one case report showed the efficacy of PRP for patients with mild CTS [16]. More extensive studies need to be performed to show the benefit of PRP injections for CTS.

• Bleeding

• Elevated blood glucose levels

• Infection

• Median nerve injury 

• Pain

• Paresthesias

The symptomatology of patients with CTS often develops insidiously over the course of months, years, or even decades. One of the most common symptoms is a “pins and needles” sensation in the first three fingers (thumb, index, and middle fingers) and nocturnal pain in the hand.[17] As the condition progresses, patients often experience intermittent pain and numbness in the affected area during daytime activities like driving, lifting, or using the computer.[17] Over time, patients complain primarily of constant pain and even swelling or the affected hand and thenar atrophy. On physical exam, practitioners may be able to see thenar wasting indicating extensive CTS.

Tinel’s and Phalen’s tests are in office maneuvers doctors may ask patients to perform to apply stress to the median nerve at the wrist.[17] A positive Tinel’s sign is elicited when percussing the carpal tunnel evokes the patient’s symptomatology. Phalen’s sign (or prayer sign) can be seen with forced wrist flexion or hyperextension for one minute. The diagnosis is most often made clinically, but many agree that nerve conduction studies are the gold standard for diagnosing.[18] The one drawback of nerve conduction testing is putting the patient through undue pain and stress.

Carpal tunnel syndrome poses a unique challenge to doctors in many specialties. As the most common peripheral nerve entrapment syndrome, it is extremely prevalent throughout the population. Wrist and hand pain, in general, can have a myriad of etiologies, including DeQuervain tenosynovitis, trigger finger, gout, carpal tunnel syndrome. Wrist and hand pain can even be referred from the neck in cervical radiculopathy or even from a cardiac condition like myocardial infarction. 

Usually, a primary care practitioner is the first person a patient sees with carpal tunnel syndrome. This provider may start conservative therapies, but for more advanced treatment options, proper coordination with a pain management doctor, rheumatologist, or orthopedist is needed. Radiologists play a vital role as well to rule out potential fractures or dislocations at the wrist after trauma. In the office setting, many pain physicians will need a team of nurse practitioners to help during the procedure to maintain sterility and help with ultrasound guidance throughout the injection. 

Proper coordination of care through different medical professionals gives patients with carpal tunnel syndrome the best chance at resolving their symptomatology.