An inferiority complex coupled with a coexisting fear of rejection are the quintessential features of AVPD. Behaviorally, this manifests as widespread avoidance of social interaction, which is ultimately the salient diagnostic feature of AVPD. This intense aversion towards rejection leads to an excessive suppression of affective expression, resulting in extreme schizoid-like introversion. Often this terrible dread of rejection emanates from a repeated history of disappointing relationships of which the patient places the onus on him/herself, thus further diminishing self-esteem. This poor self-concept is more descriptively identified as a state of malignant self-regard (MSR). MSR further exacerbates feelings of shame, personal inadequacy, alexithymia, and perfectionism, and can also be observed in masochistic, self-defeating, depressive, and vulnerable narcissistic personalities.[3]

The initial interview with the avoidant patient will prove a challenge for the clinician. These patients are often reticent and laconic. Their constant fear of the potential embarrassment of 'saying something stupid' will disrupt the interview process. The interviewer must use tact to create a therapeutic alliance in which the patient feels confident enough to be forthcoming.

The categorical identification of AVPD in DSM-V implements the following diagnostic criteria:

Feelings of inadequacy, a pervasive pattern of social inhibition, and hypersensitivity to negative evaluation are present in a variety of contexts, beginning by early adulthood as indicated by 4 (or more) of the following:

1. Avoidance of activities related to an occupation that involve significant interpersonal contact due to fears of such issues as disapproval, criticism, or rejection.
2. Do not want to get involved with people unless they are sure of being liked.
3. Displays restraint within intimate relationships because of the fear of being ridiculed or shamed.
4. Is preoccupied with being rejected or criticized or in normal social situations.
5. Shows inhibition in new interpersonal situations because of feelings of inadequacy.
6. Views self as socially inept, personally unappealing, and inferior to other people.
7. Is unusually reluctant to take personal risks or engage in new activities because they may prove embarrassing.

The alternative dimensional model of AVPD identifies the internalization of distress, high levels of negative affectivity, behavioral inhibition and avoidance, and low levels of extraversion as salient diagnostic features.[10][11]

As with most personality disorders not included within cluster B, little to no research has been conducted to treat AVPD.[12] With this antecedent noted, post hoc analyses of studies investigating social anxiety disorder (SAD), with comorbid AVPD, indicate the potential benefit of cognitive-behavioral therapeutic (CBT) approaches to alleviate AVPD symptomatology.[13] 

CBT emphasizes the acknowledgment of negative automatic thoughts and how these thoughts can negatively influence behavior. This enlightenment is then followed by the implementation of prosocial behavior to correct the aforementioned dysfunctional schemas. Some experts believe interpersonal therapy (ITP) can be beneficial for overcoming social anxiety and developing trust. Although no FDA approved pharmacologic agent exists for the treatment of AVPD, anecdotal reports reveal the improvement of symptomatology following administration of psychotropics indicated for SAD, such as serotonin-specific reuptake inhibitors.[14] Furthermore, treating comorbid psychiatric illnesses will undoubtedly improve the patient’s quality of life.

As mentioned previously, AVPD was initially believed to represent a classification within the spectrum of pathological anxiety. Experts postulated that the phenomenology of AVPD could only exist in parallel with SAD; however, this assumption has since been dispelled, as roughly two-thirds of individuals with AVPD do not meet the standard criteria for SAD.[15] Shared vulnerability factors and common diagnostic criteria result in similar clinical presentations with other cluster C disorders, such as dependent personality disorder (DPD).[16] Although undoubtedly similar, the underlying foundational anxiety and desire for physical proximity in DPD result from a fear of abandonment, whereas ruminations of possible rejection consume those with AVPD.[3] 

The pervasive isolation witnessed in both AVPD and schizoid personality disorder can be diagnostically differentiated by contrasting the active-detachment of AVPD against the schizoid trait of passive-detachment. The former constitutes a state of "actively" avoiding social engagement with the impetus to circumvent rejection, whereas the latter ambivalent "passive" isolation precipitates from a complete lack of interest. Furthermore, those who have schizoid personality disorder are insensitive to social rejection and indifferent to interpersonal engagement.[3] In effect, behavioral patterns of AVPD can mimic varying pathologies. Thus, to ensure the diagnosis's veracity, clinicians will be wise to investigate the underlying impetus of behavioral manifestations.

AVPD is considered to be a chronic disorder, as implied by its designation within the family of personality disorders. However, some studies have suggested that, with time and treatment, a subset of those diagnosed with AVPD will eventually no longer meet diagnostic criteria. Specifically, one study revealed stability of diagnosis, ten years after the initial diagnosis, estimated to be 0.51.[17] 

Although this possibility of expiation from the disorder engenders hope, evaluations of those still meeting the diagnostic threshold of AVPD reveal minimal to nonexistent symptom diminishment.[18] The prognosis for this latter group is not hopeful. Research indicates that those with AVPD are more likely to be unemployed, less educated, single, and more likely to be on disability when compared to controls.[19] Persons with AVPD are also more likely to express worse physical health, frequent doctor visits, and more significant mental distress.[20]

Avoidant personality behavior patterns generally engender further psychiatric comorbidities and a general lack of dissatisfaction with life. It is not uncommon for someone with AVPD to suffer from depression, substance abuse, and eating disorders. This discontent is represented statistically as those with AVPD have a higher incidence of suicidal ideation and suicide attempts.[15] 

Less obvious but no less serious, the aforementioned malignant self-regard experienced by the avoidant patient can lead to a dysfunctional perfectionism, which can precipitate increased diathesis for postpartum depression.[21] Because of these detrimental complications, early identification of AVPD with subsequent intensive intervention is paramount.

Insidious in nature, AVPD is a chronic and pervasive disorder, without a defining inciting event or distinguishable time of onset. Recommendations for deterrence are relegated to caregivers and entail providing a nurturing and encouraging childhood environment. Psychoeducation of the social-psychological aspects of AVPD can be profoundly insightful, ultimately leading to fruitful behavioral adaptations.

The prompt identification and management of AVPD are paramount if the patient is to lead a fruitful and satisfying life. This goal can only be accomplished with a quality dynamic between the interprofessional team. Most likely, this disorder will require not only pharmacological intervention but also intense psychotherapy and unconditional support. Staff will need to be available around the clock in the event of emergent decompensation. A well functioning team will consist of a psychiatrist, psychologist, social worker, nurses, and medical assistants.