Hexacyclonate

Hexacyclonate
Identifiers
IUPAC name
  • [1-(hydroxymethyl)cyclohexyl]acetic acid
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC9H16O3
Molar mass172.222 g·mol−1
3D model (JSmol)
SMILES
  • O=C(O)CC1(CO)CCCCC1
InChI
  • InChI=1S/C9H16O3/c10-7-9(6-8(11)12)4-2-1-3-5-9/h10H,1-7H2,(H,11,12) checkY
  • Key:WMJPAYUKEVEBCN-UHFFFAOYSA-N checkY
  (verify)

Hexacyclonate (Gevilon) is a stimulant drug. It has been used for the treatment of alcoholism[1] and for increasing motivation in elderly patients,[2] but is now mainly used for the treatment of hyperlipoproteinaemia.[3][4] It is chemically similar to the anticonvulsant gabapentin, with a hydroxyl group replacing the amine.

The latter use may be incorrectly assigned, as "Gevilon" has been used as a trade name for gemfibrozil, a well-known drug for dislypidemia.

References

  1. ↑ Chesrow EJ, Sabatini R, Musci JP, Kaplitz SE, Marquardt GH (May 1962). "Adjunctive treatment of the chronic alcoholic with hexacyclonate sodium". The Illinois Medical Journal. 121: 546–8. PMID 13878809.
  2. ↑ Morrison BO (January 1962). "Pharmaco-motivation of the geriatric patient: a preliminary report on hexacyclonate". The Journal of the Louisiana State Medical Society. 114: 23–6. PMID 14476295.
  3. ↑ Milewicz A, Plamieniak Z, Bohdanowicz-Pawlak A (1992). "Therapeutic effect of gevilon in patients with hyperlipoproteinaemia". Materia Medica Polona. Polish Journal of Medicine and Pharmacy. 24 (2): 91–5. PMID 1307777.
  4. ↑ Gazdikova K, Korecka P, Springer V, Gazdik F (2003). "Pharmacoeconomic aspects of patients treated by hemodialysis". Bratislavske Lekarske Listy. 104 (10): 329–34. PMID 15055734.
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