M current

M current is a type of noninactivating potassium current first discovered in bullfrog sympathetic ganglion cells.[1]

The M-channel is a voltage-gated K+ channel (Kv7/KCNQ family) that is named after the receptor it is influenced by. The M-channel is important in raising the threshold for firing an action potential. It is unique because it is open at rest and even more likely to be open during depolarization. Furthermore, when the muscarinic acetylcholine receptor (MAChR) is activated, the channel closes. The M-channel is a PIP2-regulated ion channel.[2] Kv7 channels have a prominent expression throughout the brain.[3]

Function

Actions of M-currents: "phasic-firing"

M-channels are the reason for slow depolarizations produced by ACh and LHRH in the autonomic ganglia and other specified areas. 1. Initial depolarization of a neuron increases likelihood that M-channels will open. 2. M-channels generate an outward potassium current (IK). 3. Potassium efflux counteracts sodium influx in action potential (AP). Overall result: full action potential is prevented. [2] : 343 

Inhibition of M-current: "tonic-firing"

1 molecule of Acetylcholine (Ach) binds to mAchR. Potassium (K+) channels become more likely to be closed. Neuron becomes tonic-firing. [2] : 343  This reduction in M-current is coupled with the actions of the Gq G-protein. Specifically, the hydrolysis of PIP2 to IP3. This hydrolysis causes PIP2, which is bound to the membrane, to become IP3 and dissociate from the membrane into the cytoplasm. When M-current is restored, it moves back to the membrane. There is some evidence for different theories of how M-channel activity is directly affected by PIP2.[2] : 229 

Clinical implications

Benign familial neonatal seizures (BFNE) is an autosomal dominant inherited form of seizures. There are three known genetic causes of BFNE, two being in the channels KCNQ2 and KCNQ3.

References

  1. ↑ Brown DA, Adams PR (February 1980). "Muscarinic suppression of a novel voltage-sensitive K+ current in a vertebrate neurone". Nature. 283 (5748): 673–6. Bibcode:1980Natur.283..673B. doi:10.1038/283673a0. PMID 6965523. S2CID 4238485.
  2. 1 2 3 4 Nicholls JG, Martin AR, Fuchs PA, Brown DA, Diamond ME, Weisblat DA (2012). From Neuron to Brain (Fifth ed.). pp. 229, 342.
  3. ↑ Greene DL, Hoshi N (February 2017). "Modulation of Kv7 channels and excitability in the brain". Cellular and Molecular Life Sciences. 74 (3): 495–508. doi:10.1007/s00018-016-2359-y. PMC 5243414. PMID 27645822.
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