Thymic carcinoma

Thymic carcinoma
Thymic carcinoma seen on CT.
SpecialtyOncology

Thymic carcinoma, or type C thymoma, is a malignancy of the thymus. It is a rare cancer that is often diagnosed at advanced stages. Recurrence following treatment is common, and thymic carcinoma is associated with a poor prognosis.[1]

Signs and symptoms

Early-stage thymic carcinoma is generally asymptomatic, and the development of symptoms is indicative of an advanced stage cancer.[2] Signs and symptoms are non-specific and include chest pain, persistent cough, and difficulty breathing, which are related to progressive tumor compression of anterior chest wall structures.[3] Superior vena cava syndrome may be associated with thymic carcinoma.[2] Thymic carcinoma is rarely associated with paraneoplastic syndromes, unlike thymoma which has a strong association with myasthenia gravis.[4]

Pathology

a-f)Pathologic findings of focal thymic carcinoma (with abundant thymoma component)

Both thymoma and thymic carcinoma originate from thymic epithelial cells; however, the epithelial cells in thymic carcinoma appear abnormal histologically, as they are infiltrative and not arranged in a lobular pattern as seen in the normal thymus.[5] Thymic carcinoma represents 20% of tumors derived from thymic epithelial cells. Compared to thymoma, the cells of thymic carcinoma behave aggressively; they are fast growing and have a higher likelihood of systemic spread.[3]

The World Health Organization separates thymoma into categories from type A to C based on histology, with type C thymoma representing the equivalent of thymic carcinoma.[2] Thymic carcinoma can be further divided into subtypes based on histopathological features. Though the genetic and molecular profile of thymic carcinoma has been shown to be different from that of thymoma,[6] immunohistochemical cell markers specific for thymic carcinoma have not yet been identified.[4]

Diagnosis

Diagnosis of thymic carcinoma is based on a combination of clinical, radiologic, and biopsy findings. Most early cases are asymptomatic and found incidentally on chest radiographs as a mass in the anterior mediastinum. Further evaluation consists of additional imaging, such as CT, MRI, and PET, and tumor biopsy, which is the gold standard and provides the definitive diagnosis.[4] Biopsy may be done prior to surgery by fine needle aspiration or during the surgery with concomitant evaluation by the pathologist.[7] Other carcinomas with malignant spread to the thymus are on the differential diagnosis and must be excluded, as they may appear similar to thymic carcinoma on histopathological examination. [2]

Staging

There is no consensus staging protocol for thymic carcinoma.[2] Both the Masaoka staging system, designed for thymoma staging, and the TNM staging system have been proposed and used for thymic carcinoma, but consensus has been limited. The Masaoka staging system has been more commonly used, but it has been suggested to have limited applicability as most thymic carcinoma patients present at an advanced stage.[4] The TNM system predicts prognosis if lymph node spread is observed;[4] however, cancer spread to lymph nodes is uncommon.[2] At the time of diagnosis, cancer spread outside of the chest cavity is estimated at less than 7%.[5]

Treatment

Treatment of thymic carcinoma depends on the stage,[2] though initial resection of the entire tumor or surgical debulking is standard. Patients with complete resection of the tumor may undergo subsequent radiation therapy and may also require chemotherapy.[3] For those with incomplete tumor resection, chemotherapy with or without radiation therapy followed by repeat surgical resection may be warranted.[3] Other treatment options include hormone therapy, targeted therapy, and experimental immunotherapy.[3][7]

Prognosis

As thymic carcinoma tends to be diagnosed at later stages, prognosis tends to be poor, with some studies estimating 30 to 55% of patients survive 5 years following diagnosis.[8][2] Recurrence following complete resection is common, with one case series finding a recurrence rate as high as 50%.[2]

Epidemiology

A study examining cases of thymic carcinoma in the United States from 2001 to 2015 found a peak incidence from 70 to 74 years old and a higher incidence in males compared to females. After thymoma, thymic carcinoma is the second most common type of thymus cancer.[8]

References

  1. ↑ "NCI Dictionary of Cancer Terms". National Cancer Institute. 2 February 2011. Archived from the original on 17 December 2021. Retrieved 14 June 2019.
  2. 1 2 3 4 5 6 7 8 9 Tseng, Yau-Lin (2011-08-01). "Thymic carcinoma: A rare cancer requiring special attention". Formosan Journal of Surgery. 44 (4): 136–140. doi:10.1016/j.fjs.2011.08.007. ISSN 1682-606X. Archived from the original on 2022-10-13. Retrieved 2022-10-25.
  3. 1 2 3 4 5 "Thymoma and Thymic Carcinoma Treatment (Adult) (PDQ®)–Patient Version - NCI". www.cancer.gov. 2005-07-08. Archived from the original on 2022-10-10. Retrieved 2022-10-10.
  4. 1 2 3 4 5 Alqaidy, Doaa; Moran, Cesar A. (2022-04-08). "Thymic Carcinoma: A Review". Frontiers in Oncology. 12: 808019. doi:10.3389/fonc.2022.808019. ISSN 2234-943X. PMC 9024054. PMID 35463355. Archived from the original on 2022-10-11. Retrieved 2022-10-25.
  5. 1 2 Robinson, Shawn P.; Akhondi, Hossein (2022), "Thymoma", StatPearls, Treasure Island (FL): StatPearls Publishing, PMID 32644717, archived from the original on 2022-05-29, retrieved 2022-10-22
  6. ↑ Marx, Alexander; Chan, John K. C.; Chalabreysse, Lara; Dacic, Sanja; Detterbeck, Frank; French, Christopher A.; Hornick, Jason L.; Inagaki, Hiroshi; Jain, Deepali; Lazar, Alexander J.; Marino, Mirella; Marom, Edith M.; Moreira, Andre L.; Nicholson, Andrew G.; Noguchi, Masayuki (2022-02-01). "The 2021 WHO Classification of Tumors of the Thymus and Mediastinum: What Is New in Thymic Epithelial, Germ Cell, and Mesenchymal Tumors?". Journal of Thoracic Oncology. 17 (2): 200–213. doi:10.1016/j.jtho.2021.10.010. ISSN 1556-0864. Archived from the original on 2022-10-22. Retrieved 2022-10-25.
  7. 1 2 "Thymoma and Thymic Carcinoma". Cleveland Clinic. Archived from the original on 2022-10-10. Retrieved 2022-10-10.
  8. 1 2 Hsu, Chun-Hsiang; Chan, John K.; Yin, Chun-Hao; Lee, Ching-Chih; Chern, Chyi-Uei; Liao, Cheng-I (2019-12-31). "Trends in the incidence of thymoma, thymic carcinoma, and thymic neuroendocrine tumor in the United States". PLoS ONE. 14 (12): e0227197. doi:10.1371/journal.pone.0227197. ISSN 1932-6203. PMC 6938371. PMID 31891634. Archived from the original on 2022-10-15. Retrieved 2022-10-25.
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