Vilanterol

Vilanterol
Names
Trade namesWith fluticasone: Breo Ellipta, Relvar Ellipta
With umeclidinium: Anoro Ellipta
With both: Trelegy Ellipta
IUPAC name
  • 4-{(1R)-2-[(6-{2-[(2,6-Dichlorobenzyl)oxy]ethoxy}hexyl)amino]-1-hydroxyethyl}-2-(hydroxymethyl)phenol
Clinical data
Main usesCOPD, asthma[1][2]
Side effectsNose and throat irritation, thrush, chest pain[2]
Pregnancy
category
  • AU: B3
    Routes of
    use
    By inhalation
    External links
    AHFS/Drugs.comMonograph
    US NLMVilanterol
    Legal
    License data
    Legal status
    • AU: S4 (Prescription only)
    • UK: POM (Prescription only)
    • US: ℞-only
    • In general: ℞ (Prescription only)
    Chemical and physical data
    FormulaC24H33Cl2NO5
    Molar mass486.43 g·mol−1
    3D model (JSmol)
    SMILES
    • c1cc(c(c(c1)Cl)COCCOCCCCCCNC[C@@H](c2ccc(c(c2)CO)O)O)Cl
    InChI
    • InChI=1S/C24H33Cl2NO5/c25-21-6-5-7-22(26)20(21)17-32-13-12-31-11-4-2-1-3-10-27-15-24(30)18-8-9-23(29)19(14-18)16-28/h5-9,14,24,27-30H,1-4,10-13,15-17H2/t24-/m0/s1
    • Key:DAFYYTQWSAWIGS-DEOSSOPVSA-N

    Vilanterol is a medication primarily used to treat chronic obstructive pulmonary disease (COPD).[2] It may also be used to prevent worsening in asthma.[1] It is inhaled in combination with other medications.[1]

    Common side effects include nose and throat irritation, thrush, and chest pain.[2] Other side effects may include anaphylaxis and bronchospasm.[2] It is a long-acting β2 adrenoreceptor agonist (LABA).[2]

    Vilanterol in combination with fluticasone was approved for medical use in the United States in 2013.[3] It is also avaliable as umeclidinium/vilanterol and fluticasone/umeclidinium/vilanterol.[2][1] In the United Kingdom a month of medication costs the NHS about £20 to £45 as of 2021.[1] In the United States this amount costs about 190 USD.[4]

    Medical uses

    Combinations

    Vilanterol is available in following combinations:

    Dosage

    It is used by inhalation once per day.[1]

    See also

    • Salmeterol—a long-acting β2 adrenoreceptor agonist (LABA) with a similar backbone.

    References

    1. 1 2 3 4 5 6 BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 279. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)
    2. 1 2 3 4 5 6 7 "Vilanterol Monograph for Professionals". Drugs.com. Archived from the original on 17 January 2021. Retrieved 15 September 2021.
    3. "FDA approves Breo Ellipta to treat chronic obstructive pulmonary disease". web.archive.org. 18 January 2017. Archived from the original on 18 January 2017. Retrieved 15 September 2021.{{cite web}}: CS1 maint: bot: original URL status unknown (link)
    4. "Breo Ellipta Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 25 April 2020. Retrieved 15 September 2021.
    Identifiers:
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