Angiomyofibroblastoma

Angiomyofibroblastoma is a non-cancerous soft tissue tumor.[1] It typically presents as a painless, slow growing mass in the vulvovaginal area of females, but can also be observed in males.[1]

The World Health Organization, 2020, reclassified these tumors as a specific type of tumor in the category of fibroblastic and myofibroblastic tumors.[2]

The gross features of AMFB are well-circumscribed. It also has low tendency for local recurrence.

Location

Pathology

Microscopical examination shows abundant thin-walled blood vessels with hypocellular and hypercellular areas.

Immunohistochemistry

Almost all tumor cells have immunoreactivity for both desmin and vimentin. It also express estrogen receptors and/or progesterone receptors, but staining for cytokeratin is negative.[7]

References

  1. 1 2 WHO Classification of Tumours Editorial Board, ed. (2020). "1. Soft tissue tumours: Angiomyofibroblastoma". Soft Tissue and Bone Tumours: WHO Classification of Tumours. Vol. 3 (5th ed.). Lyon (France): International Agency for Research on Cancer. pp. 78–79. ISBN 978-92-832-4503-2.
  2. ↑ Sbaraglia M, Bellan E, Dei Tos AP (April 2021). "The 2020 WHO Classification of Soft Tissue Tumours: news and perspectives". Pathologica. 113 (2): 70–84. doi:10.32074/1591-951X-213. PMC 8167394. PMID 33179614.
  3. ↑ Wang, J; Sheng, W; Tu, X; Shi, D; Zhu, X; Zhang, R (2000). "Clinicopathologic analysis of angiomyofibroblastoma of the female genital tract". Chinese Medical Journal. 113 (11): 1036–9. PMID 11776120.
  4. ↑ Seo, J. W.; Lee, K. A.; Yoon, N. R.; Lee, J. W.; Kim, B. G.; Bae, D. S. (2013). "Angiomyofibroblastoma of the vulva". Obstetrics & Gynecology Science. 56 (5): 349–51. doi:10.5468/ogs.2013.56.5.349. PMC 3784123. PMID 24328028.
  5. ↑ Lim, K. J.; Moon, J. H.; Yoon, D. Y.; Cha, J. H.; Lee, I. J.; Min, S. J. (2008). "Angiomyofibroblastoma arising from the posterior perivesical space: A case report with MR findings". Korean Journal of Radiology. 9 (4): 382–5. doi:10.3348/kjr.2008.9.4.382. PMC 2627271. PMID 18682679.
  6. ↑ Tzanakis, N. E.; Giannopoulos, G. A.; Efstathiou, S. P.; Rallis, G. E.; Nikiteas, N. I. (2010). "Angiomyofibroblastoma of the spermatic cord: A case report". Journal of Medical Case Reports. 4: 79. doi:10.1186/1752-1947-4-79. PMC 2838917. PMID 20202207.
  7. ↑ Seo, J. W.; Lee, K. A.; Yoon, N. R.; Lee, J. W.; Kim, B. G.; Bae, D. S. (2013). "Angiomyofibroblastoma of the vulva". Obstetrics & Gynecology Science. 56 (5): 349–51. doi:10.5468/ogs.2013.56.5.349. PMC 3784123. PMID 24328028.
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