Burkholderia thailandensis

Burkholderia thailandensis
Burkholderia thailandensis on Ashdown's media
Scientific classification
Domain: Bacteria
Phylum: Proteobacteria
Class: Betaproteobacteria
Order: Burkholderiales
Family: Burkholderiaceae
Genus: Burkholderia
Species:
B. thailandensis
Binomial name
Burkholderia thailandensis
Brett et al. 1998[1]

Burkholderia thailandensis is a nonfermenting motile, Gram-negative bacillus that occurs naturally in soil. It is closely related to Burkholderia pseudomallei, but unlike B. pseudomallei, it only rarely causes disease in humans or animals.[2][3][4][5] The lethal inoculum is approximately 1000 times higher than for B. pseudomallei.[6] It is usually distinguished from B. pseudomallei by its ability to assimilate arabinose.[7] Other differences between these species include lipopolysaccharide composition, colony morphology, and differences in metabolism.[8]

Use in research

Burkholderia thailandensis is sometimes used to model B. pseudomallei infection in mice because of similarities in the immune response.[9][10][11] B. thailandensis does not require biosafety category 3 facilities and is not considered a biosecurity threat, which makes it easier to study and to work with.[12]

Small RNA

Research suggests that as in other bacteria, small non coding RNAs play a role in response to the environmental and stress conditions like antibiotic exposure and survival in a host-specific environment.[13] Several small RNA have been discovered in B. thailandenisis: BHT_s1 and BHT_s39 exhibit differential expression profiles dependent on growth phase and cell stimuli, such as antibiotics and serum. BHT_s39 could function in bacterial metabolism and adaptation to host. BTH_s13 and BTH_s19 may regulate expression of their downstream gene.[13]

References

  1. ↑ Brett PJ, DeShazer D, Woods DE (1998). "Burkholderia thailandensis sp. nov., a Burkholderia pseudomallei-like species". Int J Syst Bacteriol. 48: 317–320. doi:10.1099/00207713-48-1-317. PMID 9542103.
  2. ↑ Wuthiekanun V, Smith MD, Dance DA, Walsh AL, Pitt TL, White NJ (1996). "Biochemical characteristics of clinical and environmental isolates of Burkholderia pseudomallei". J Med Microbiol. 45 (6): 408–12. doi:10.1099/00222615-45-6-408. PMID 8958243.
  3. ↑ Smith MD, Angus BJ, Wuthiekanun V, White NJ (1997). "Arabinose assimilation defines a nonvirulent biotype of Burkholderia pseudomallei". Infect Immun. 65 (10): 4319–21. doi:10.1128/IAI.65.10.4319-4321.1997. PMC 175618. PMID 9317042.
  4. ↑ Lertpatanasuwan N, Sermsri K, Petkaseam A, Trakulsomboon S, Thamlikitkul V, Suputtamongkol Y (1999). "Arabinose-positive Burkholderia pseudomallei infection in humans: case report". Clin Infect Dis. 28 (4): 927–28. doi:10.1086/517253. PMID 10825075.
  5. ↑ Glass MB, Gee JE, Steigerwalt AG, et al. (2006). "Pneumonia and Septicemia Caused by Burkholderia thailandensis in the United States". J Clin Microbiol. 44 (12): 4601–04. doi:10.1128/JCM.01585-06. PMC 1698378. PMID 17050819.
  6. ↑ Wiersinga WJ, de Vos AF, de Beer R, et al. (2007). "Inflammation patterns induced by different Burkholderia species in mice". Cell Microbiol. 10 (1): 81–87. doi:10.1111/j.1462-5822.2007.01016.x. PMID 17645551. S2CID 22030395.
  7. ↑ Smith MD, Angus BJ, Wuthiekanun V, White NJ (1997). "Arabinose assimilation defines a nonvirulent biotype of Burkholderia pseudomallei". Infect Immun. 65 (10): 4319–321. doi:10.1128/IAI.65.10.4319-4321.1997. PMC 175618. PMID 9317042.
  8. ↑ Woods DE (1999). "Species versus Biotype Status". J Clin Microbiol. 37 (11): 3786–7. PMC 85768. PMID 10610379.
  9. ↑ Wiersinga WJ, de Vos AF, de Beer R, Wieland CW, Roelofs JJTH, Woods DE (2008). "Inflammation patterns induced by different Burkholderia species in mice". Cell Microbiol. 10 (1): 81–7. doi:10.1111/j.1462-5822.2007.01016.x. PMID 17645551. S2CID 22030395.
  10. ↑ Haraga A, West TE, Brittnacher MJ, Skerrett SJ, Miller SI (2008). "Burkholderia thailandensis as a model system for the Study of the virulence-associated type III secretion system of Burkholderia pseudomallei". Infect Immun. 76 (11): 5402–11. doi:10.1128/IAI.00626-08. PMC 2573339. PMID 18779342.
  11. ↑ Morici LA, Heang J, Tate T, Didier PJ, Roy CJ (2010). "Differential susceptibility of inbred mouse strains to Burkholderia thailandensis aerosol infection". Microb Pathog. 48 (1): 9–17. doi:10.1016/j.micpath.2009.10.004. PMC 7006035. PMID 19853031.
  12. ↑ Haraga A, West TE, Brittnacher MJ, Skerrett SJ, Miller SI (2008). "Burkholderia thailandensis as a Model System for the Study of the Virulence-Associated Type III Secretion System of Burkholderia pseudomallei". Infect Immun. 76 (11): 5402–11. doi:10.1128/IAI.00626-08. PMC 2573339. PMID 18779342.
  13. 1 2 Stubben, Chris J.; Micheva-Viteva, Sofiya N.; Shou, Yulin; Buddenborg, Sarah K.; Dunbar, John M.; Hong-Geller, Elizabeth (2014-05-19). "Differential expression of small RNAs from Burkholderia thailandensis in response to varying environmental and stress conditions". BMC Genomics. 15: 385. doi:10.1186/1471-2164-15-385. ISSN 1471-2164. PMC 4035088. PMID 24884623.


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