Chondrocalcinosis

Chondrocalcinosis
X-ray of a knee with chondrocalcinosis
SpecialtyRadiology

Chondrocalcinosis or cartilage calcification is calcification (accumulation of calcium salts) in hyaline cartilage and/or fibrocartilage.[1] It can be seen on radiography.

Signs and symptoms

The clinical presentation of chondrocalcinosis is as follows:[2]

  • Chronic joint pain
  • Swelling of joints

Causes

Buildup of calcium phosphate in the ankle joints has been found in about 50% of the general population, and may be associated with osteoarthritis.[3]

Another common cause of chondrocalcinosis is calcium pyrophosphate dihydrate crystal deposition disease (CPPD).[4] CPPD is estimated to affect 4% to 7% of the adult populations of Europe and the United States.[5] Previous studies have overestimated the prevalence by simply estimating the prevalence of chondrocalcinosis regardless of cause.[5]

A magnesium deficiency may cause chondrocalcinosis, and magnesium supplementation may reduce or alleviate symptoms.[6] In some cases, arthritis from injury can cause chondrocalcinosis.[7] Other causes of chondrocalcinosis include:[4]

Diagnosis

X-ray of the knees, appearance of joint chondrocalcinosis

Chondrocalcinosis can be visualized on projectional radiography, CT scan, MRI, US, and nuclear medicine.[1] CT scans and MRIs show calcific masses (usually within the ligamentum flavum or joint capsule), however radiography is more successful.[1] At ultrasound, chondrocalcinosis may be depicted as echogenic foci with no acoustic shadow within the hyaline cartilage.[8] As with most conditions, chondrocalcinosis can present with similarity to other diseases such as ankylosing spondylitis and gout.[1]

Treatment

The management of chondrocalcinosis is based on the following:[2]

References

  1. 1 2 3 4 Rothschild, Bruce M Calcium Pyrophosphate Deposition Disease (radiology)
  2. 1 2 "Chondrocalcinosis 2". NORD (National Organization for Rare Disorders). Archived from the original on 13 May 2022. Retrieved 22 September 2022.
  3. ↑ Hubert, Jan; Weiser, Lukas; Hischke, Sandra; Uhlig, Annemarie; Rolvien, Tim; Schmidt, Tobias; Butscheidt, Sebastian Karl; Püschel, Klaus; Lehmann, Wolfgang; Beil, Frank Timo; Hawellek, Thelonius (2018). "Cartilage calcification of the ankle joint is associated with osteoarthritis in the general population". BMC Musculoskeletal Disorders. 19 (1). doi:10.1186/s12891-018-2094-7. ISSN 1471-2474. PMC 5968601.
  4. 1 2 Matt A. Morgan; Frank Gaillard; et al. "Chondrocalcinosis". Radiopedia. Archived from the original on 2019-11-13. Retrieved 2017-08-11.
  5. 1 2 Ann K. Rosenthal. "Clinical manifestations and diagnosis of calcium pyrophosphate crystal deposition (CPPD) disease". UpToDate. Archived from the original on 2019-04-07. Retrieved 2022-03-15. This topic last updated: Jul 24, 2018.
  6. ↑ de Filippi JP, Diderich PP, Wouters JM (1992). "Hypomagnesemia and chondrocalcinosis". Ned Tijdschr Geneeskd. 136 (20): 139–41. PMID 1732847.
  7. ↑ Wright GD, Doherty M (1997). "Calcium pyrophosphate crystal deposition is not always 'wear and tear' or aging". Ann. Rheum. Dis. 56 (10): 586–8. doi:10.1136/ard.56.10.586. PMC 1752269. PMID 9389218.
  8. ↑ Arend CF. Ultrasound of the Shoulder. Master Medical Books, 2013. Free chapter on acromioclavicular chondrocalcinosis is available at ShoulderUS.com Archived 2017-07-14 at the Wayback Machine
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