Dextran 40

Dextran 40
Names
Trade namesLMD, Rheomacrodex, others
Other namesLow viscosity dextran[1]
Clinical data
Drug classColloid[1]
Main usesExpand blood volume[2]
Side effectsVolume overload, kidney problems, acidosis, allergic reactionss, poor blood clotting[2]
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Pregnancy
category
  • US: Intravenous
    External links
    AHFS/Drugs.comMonograph
    Legal
    Legal status
    Chemical and physical data
    Molar mass70,000 Da

    Dextran 40, sold under the brand name LMD among others, is a type of fluid given by injection into a vein to expand blood volume.[2] Specifically it is used for shock such as that caused by bleeding or burns when blood transfusions are not quickly available.[2] However, it does not carry oxygen.[3]

    Side effects may include volume overload, kidney problems, acidosis, allergic reactionss, and poor blood clotting.[2] It is not recommended in severe kidney failure, heart failure, or clotting disorders.[2] Use may interfere with certain blood tests.[2]

    Dextran 40 came into medical use in 1961.[4] It is a glucose polymer with a typical molecular weight of 40 kDa.[1][4] It works by pulling fluid from the extravascular space into the blood vessels.[2] It is a non protein based colloid solution.[2][1]

    Medical uses

    Other uses may include as a starting fluid for extracorporeal circulation.[1] And to decrease the risk of blood clots during certain surgeries.[1]

    Dosage

    In adults the first half liter may give given rapidly.[2] In children 5 to 10 mL/kg may be used.[2]

    See also

    References

    1. 1 2 3 4 5 6 "DailyMed - LMD IN DEXTROSE- dextran 40 injection, solution LMD IN SODIUM CHLORIDE- dextran 40 injection, solution". dailymed.nlm.nih.gov. Archived from the original on 14 April 2021. Retrieved 23 December 2021.
    2. 1 2 3 4 5 6 7 8 9 10 11 "Dextran 40 Monograph for Professionals". Drugs.com. Archived from the original on 3 January 2017. Retrieved 22 July 2021.
    3. ↑ Howe, Tiffany; Burton, Angela (10 December 2019). Pharmacology for the Surgical Technologist - E-Book. Elsevier Health Sciences. p. 155. ISBN 978-0-323-66122-5. Archived from the original on 11 January 2022. Retrieved 23 December 2021.
    4. 1 2 Alexander, Martin; Bloom, Barry R.; Hopwood, David A.; Hull, Roger; Iglewski, Barbara H.; Laskin, Allen I.; Oliver, Stephen G.; Schaechter, Moselio; Summers, William C. (10 February 2000). Encyclopedia of Microbiology, Four-Volume Set. Academic Press. p. 562. ISBN 978-0-08-054848-7. Archived from the original on 11 January 2022. Retrieved 23 December 2021.
    Identifiers:
    • CAS Number: 9004-54-0
    • "Dextran 70". Drug Information Portal. U.S. National Library of Medicine. Archived from the original on 2021-08-28. Retrieved 2021-07-22.
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