Dharmendra antigen

The Dharmendra antigen is a test widely used in India. The antigen is a suspension of de-fatted leprosy bacilli which has been extracted with chloroform-ether and killed, either by heat, or by other effective methods. This antigen was first reported by Dharmendra in 1941–42 and later standardized in 1979 by Sangupta et al.[1]

Dharmendra's Lepromin suspension consists of 10 mg of the dried and de-fatted, bacillary powder, dissolved in 100 ml carbol saline solution. It is a revised form of the original Lepromin test developed in 1919 by Kensuke Mitsuda. The Dharmendra test allows to differentiate tuberculoid leprosy from lepromatous leprosy.

References

  1. ↑ Mohanty J, Mohanty H C. Lepromin response with dharmendra antigen in patients with leprosy. Indian J Dermatol Venereol Leprol [serial online] 1997 [cited 2016 Jun 20];63:385-7. Available from: http://www.ijdvl.com/text.asp?1997/63/6/385/4627
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