Entospletinib
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Other names | GS-9973 |
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Formula | C23H21N7O |
Molar mass | 411.469 g·mol−1 |
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Entospletinib is an experimental drug for the treatment of various types of cancer under development by Gilead Sciences. It is an inhibitor of spleen tyrosine kinase (Syk).[1] It has entered clinical trials for acute myeloid leukaemia (AML), chronic lymphocytic leukemia (CLL),[2] diffuse large B cell lymphoma (DLBCL), graft-versus-host disease (GvHD), hematological malignancies, mantle cell lymphoma (MCL), and non-Hodgkin lymphoma (NHL).[3]
References
- ↑ "Definition of entospletinib". NCI Cancer Dictionary. National Cancer Institute.
- ↑ Sharman J, Di Paolo J (June 2016). "Targeting B-cell receptor signaling kinases in chronic lymphocytic leukemia: the promise of entospletinib". Therapeutic Advances in Hematology. 7 (3): 157–70. doi:10.1177/2040620716636542. PMC 4872176. PMID 27247756.
- ↑ "Entospletinib - Gilead Sciences". Adis Insight.
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