Fatty acid oxidation inhibitors

Fatty acid oxidation inhibitors are a new potent class of drugs used in treatment of stable angina pectoris and an addition in treatment of chronic heart failure.

Drugs

  • CPT-I inhibitors: Etomoxir, Oxfenicine, Perhexiline
    CPT-I (carnitine palmitoyl transferase) converts fatty acyl-CoA to fatty acyl-carnitine.
  • Carnitine biosynthesis inhibitor: Mildronate[1]
  • 3-KAT inhibitors: Trimetazidine
    3-KAT (3-ketoacyl-coenzyme A thiolase) inhibitors directly inhibits fatty acid beta-oxidation.
  • pFOX directly inhibits fatty acid beta-oxidation.[2]

References

  1. ↑ Liepinsh, E; Vilskersts, R; Loca, D; et al. (December 2006). "Mildronate, an inhibitor of carnitine biosynthesis, induces an increase in gamma-butyrobetaine contents and cardioprotection in isolated rat heart infarction". J. Cardiovasc. Pharmacol. 48: 314–9. doi:10.1097/01.fjc.0000250077.07702.23. PMID 17204911.
  2. ↑ Partial fatty acid oxidation inhibitors: a potentially new class of drugs for heart failure; European Journal of Heart Failure 4 2002. 3-6; http://eurjhf.oxfordjournals.org/content/4/1/3.full.pdf+html Archived 2013-08-21 at the Wayback Machine
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