Flavonoid alkaloid

A flavonoid alkaloid also known as a flavoalkaloid is a type of natural product produced by plants that contains both a flavonoid core structure and a nitrogen containing substituent so that the substance is also classified as an alkaloid.[1] The most common flavonoid alkaloids contain a nitrogen heterocycle such as a pyridine or piperidine which is covalently bonded to the A-ring of a chromone. One flavonoid alkaloid, lilaline, was isolated from Lilium candidum in 1987.[2] The synthesis of flavonoid alkaloids has been achieved [3]

Pharmacology

A number of flavonoid alkaloids have been discovered that possess diverse pharmacological activity that may have application in the treatment of a range of diseases. One example is alvocidib, a potent CDK9 kinase inhibitor that is being developed for the treatment of chronic lymphocytic leukemia (CLL) and acute myeloid leukemia (AML).[4][5] Flavonoid alkaloids were also found to present alpha-glucosidase inhibitory activity through artificial organic synthesis. [3]

References

  1. ↑ Khadem S, Marles RJ (2011). "Chromone and flavonoid alkaloids: occurrence and bioactivity". Molecules. 17 (1): 191–206. CiteSeerX 10.1.1.378.190. doi:10.3390/molecules17010191. PMC 6268529. PMID 22202807.
  2. ↑ Mašterová I, Uhrin D, Tomko J (1987). "Lilaline—a flavonoid alkaloid from Lilium candid". Phytochemistry. 26 (6): 1844–1845. doi:10.1016/S0031-9422(00)82304-3.
  3. 1 2 Zhen, J., Dai, Y., Villani, T., Giurleo, D., Simon, J. and Wu, Q., 2017. Synthesis of novel flavonoid alkaloids as α-glucosidase inhibitors. Bioorganic & Medicinal Chemistry.
  4. ↑ Jain SK, Bharate SB, Vishwakarma RA (2012). "Cyclin-dependent kinase inhibition by flavoalkaloids". Mini Rev Med Chem. 12 (7): 632–49. doi:10.2174/138955712800626683. PMID 22512551.
  5. ↑ Bose P, Simmons GL, Grant S (2013). "Cyclin-dependent kinase inhibitor therapy for hematologic malignancies". Expert Opin Investig Drugs. 22 (6): 723–38. doi:10.1517/13543784.2013.789859. PMC 4039040. PMID 23647051.
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