Hair cloning

Hair multiplication or hair cloning is a proposed technique to counter hair loss. The technology to clone hair is in its early stages. Experts previously assumed that in the case of complete baldness, follicles are completely absent from the scalp, so they cannot be regenerated. However it was discovered that the follicles are not entirely absent, as there are stem cells in the bald scalp from which the follicles naturally arise. Abnormal behavior of these follicles is suggested to be the result of progenitor cell deficiency in these areas.

The basic idea of hair cloning is that healthy follicle cells or dermal papillae can be extracted from the subject from areas that are not bald and are not suffering hair loss, they can be multiplied (cloned) by various culturing methods[1] and the newly produced cells can be injected back in the bald scalp, where they would act healthy and produce hair. In 2015, initial trials for human hair were successful in generating new follicles,[2] but the hairs grew in various different directions giving an unnatural look. As of 2019, scientists believe they may have solved this problem by using nearly microscopic 3D printed shafts to assist follicles growing upward through the scalp. This technique however is still in research phase and is not available for public or commercial use.

Research

Intercytex

One of the first companies to begin experiment with hair cloning was Intercytex. Researchers at the company were convinced that their approach was the cure for baldness, and if the technology is fully developed, they can basically eliminate hair loss due to hereditary factors. This therapy would also eliminate the need for donor hair, as it can be simply grown from the patient's own cells.[3]

Intercytex tried to clone new hair follicles from the stem cells harvested from the back of the neck. They hoped that if they multiplied (cloned) the follicles and then implanted them back in the scalp in the bald areas they would be successful in regrowing the hair itself. They tested the method in their Phase II trials, which showed very promising results as two-thirds of the bald male patients were able to grow new hair after the treatment.

The company was hoping to complete the research so they can make it available to the public, so they began Phase III trials. They estimated they would be able to finish the process in a few years. However, these tests did not show the expected progress. In 2008 Intercytex admitted that they failed in fully developing the hair cloning therapy and decided to discontinue all research.

This was not solely the result of the failed tests, as the company's financial background also became unstable in 2008 and they had to implement several cost-cutting measures.[4] They laid off a great number of staff members and cut funding to the research projects such as hair cloning. In 2010 they went out of business.

Aderans Research Institute

Another firm researching hair cloning was ARI (Aderans Research Institute), a Japanese company which operated in the US and was the greatest competitor of Intercytex in developing the therapy. The company worked on what they called the "Ji Gami" process, which involved the removal of a small strip of the scalp, which is broken down into individual follicular stem cells. After the extraction these cells are cultured, multiplied and injected back into the bald areas of the scalp. Scientists hoped that after implantation these cloned follicular cells would mature into full grown hair.

During Phase II trials they found that the process was not suitable for multiplication but instead it revitalized the follicles and successfully prevented future loss. The trials continued in 2012. Aderans decided to discontinue the funding of its hair multiplication research in July 2013.[5]

Berlin Technical University

The first time scientists were able to grow artificial hair follicles from stem cells was in 2010. Scientists of the Berlin Technical University in Germany took animal cells and created the follicles by using them. As a result, they produced follicles "thinner than normal", but they were confident they could develop the right method of cloning hair from human stem cells by 2011. They estimated that the therapy would be publicly available by 2015 as they were already preparing for the clinical trials. Scientists working on the project said if the treatment was finished, it would mean a cure for approximately 80 percent of those who suffer from hair loss.[6]

The university was working together with Intercytex and several other research teams, but they encountered several problems. One of them was that the multiplication process was not efficient enough. They were only able to clone one or two follicles from an extracted hair but for the process to be efficient this number should have been around 1000. There was no indication that researchers were able to overcome this obstacle.[7]

University of Pennsylvania

In 2012 scientists from the University of Pennsylvania School of Medicine published their own findings regarding hair cloning.[8] During their investigation they found that non-bald and bald scalps have the same number of stem cells, but progenitor cell number was significantly depleted in the case of the latter. Based on this, they concluded that it is not the absence of the stem cells that is responsible for the hair loss but the unsuccessful activation of said cells.[9]

The researchers continued their investigation and are looking for a way to convert regular stem cells into progenitor cells, which could mean they may be able to activate the natural generation of hair on a previously bald scalp.[10][11]

Durham University

In late 2013, new results were published by a research team at the Durham University which suggested progress. The scientists tried a new method for multiplying, cloning the original cells not in a 2D but in a 3D system.[12]

A team took healthy dermal papillae from hair transplants and dissected them, then cultured them in a petri dish. In 30 hours they were able to produce 3000 dermal papilla cells. The goal was to create dermal papillae that when injected would reprogram cells around it to produce healthy hair. They chose to try the method by injecting the cloned cells in foreskin samples to "challenge" the cells, as the cells in foreskin normally don't grow hair. The human skin samples were grafted on rats. After six weeks the cloned papillae cells formed brand new hair follicles which were able to grow hair.

These are early results and as it is a new approach to hair cloning, several more studies and tests have to be conducted before they can move on to human testing. They also encountered new problems, such as that some of the newly grown hair appeared without pigmentation.

RepliCel Life Sciences

Vancouver-based firm, RepliCel Life Sciences Inc. has been researching the replacing of hormone-compromised hair-follicle cells.

In 2013, RepliCel created a partnership with cosmetics company Shiseido, giving Shiseido an exclusive license to use its RCH-01 technology in Japan, China, South Korea, Taiwan and the ASEAN countries.[13] Shiseido is currently trialing RepliCel's RCH-01 in Japan for market approval by the end of 2018.

RCH-01 Is currently in Clinical Phase III as of 2022 according to the Replicel website

Riken Centre for Developmental Biology

In 2016, scientists in Japan announced they had successfully grown human skin in a lab.[14] The skin was created using induced pluripotent stem cells, and when implanted in a mouse, the skin grew hairs successfully. Clinical results are expected to come out around 2019.

Stemson Therapeutics

In July 2019, a researcher from San Diego-based Stemson Therapeutics, partnered with UCSD, successfully grew his own follicles on a mouse using iPSC-derived epithelial and dermal cell therapy. The hair grew straight and was aligned properly with a 3D printed biodegradable shaft. The hairs were permanent and regenerated naturally.[15]

See also

References

  1. ↑ "Methods of Hair cloning". hairforlife.info. 21 July 2020. Retrieved 21 July 2020.
  2. ↑ "Grow New Follicles". columbia.edu. 14 December 2013. Retrieved 21 July 2020.
  3. ↑ "Hair Care and Trichology | Health Articles | The Future of Hair Restoration". Worldwidehealth.com. 31 January 2014. Retrieved 5 February 2014.
  4. ↑ "Intercytex Discontinues its Hair Multiplication Development Operations | Hair Loss Q & A". Regrowhair.com. 7 January 2010. Retrieved 5 February 2014.
  5. ↑ "Aderans to no Longer Fund its Hair Multiplication Research | Hair Loss Q & A". Regrowhair.com. 30 July 2013. Retrieved 5 February 2014.
  6. ↑ "Study: Cure for Baldness Could Happen in 5 Years". Fox News. 16 December 2010. Retrieved 5 February 2014.
  7. ↑ "Stem Cell Research and Hair Loss". Stem Cell Hair Replacement. Retrieved 5 February 2014.
  8. ↑ "Perelman School of Medicine Experts Identify Inhibitor Causing Male Pattern Baldness and Target for Hair Loss Treatments".
  9. ↑ Chueh, S. C.; Lin, S. J.; Chen, C. C.; Lei, M.; Wang, L. M.; Widelitz, R. B.; Hughes, M. W.; Jiang, T. X.; Chuong, C. M. (2013). "Therapeutic strategy for hair regeneration: Hair cycle activation, niche environment modulation, wound-induced follicle neogenesis and stem cell engineering". Expert Opinion on Biological Therapy. 13 (3): 377–391. doi:10.1517/14712598.2013.739601. PMC 3706200. PMID 23289545.
  10. ↑ "Penn Medicine News: Male Pattern Balding May Be Due to Stem Cell Inactivation, According to Penn Study". Uphs.upenn.edu. 4 January 2011. Retrieved 5 February 2014.
  11. ↑ "Stem cells hold key to cure for baldness - health - 05 January 2011". New Scientist. Retrieved 5 February 2014.
  12. ↑ "3D drops raise hopes of cure for baldness - health - 21 October 2013". New Scientist. Retrieved 5 February 2014.
  13. ↑ Jefferson, Robin Seaton. "Company Uses Patients' Own Cells To Put An End To Baldness, Aging Skin And Tendon Degeneration". Forbes. Retrieved 14 April 2018.
  14. ↑ Takagi R, Ishimaru J, Sugawara A, Toyoshima KE, Ishida K, Ogawa M, Sakakibara K, Asakawa K, Kashiwakura A, Oshima M, Minamide R, Sato A, Yoshitake T, Takeda A, Egusa H, Tsuji T (1 April 2016). "Bioengineering a 3D integumentary organ system from iPS cells using an in vivo transplantation model". Science Advances. 2 (4): e1500887. Bibcode:2016SciA....2E0887T. doi:10.1126/sciadv.1500887. PMC 4820374. PMID 27051874.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  15. ↑ "Functional hair follicles grown from stem cells". 12 July 2019. {{cite journal}}: Cite journal requires |journal= (help)

Further reading

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