Inosine pranobex

Isoprinosine
INN: Inosine acedoben dimepranol
	Chemical structures of the three components of inosine pranobex (from top to bottom: inosine, acedoben and dimethylamino isopropanol)
Combination of
Inosine	Immunostimulant
Dimethylaminoisopropanol	Immunostimulant
Acedoben	Immunostimulant
Clinical data
Trade names	Imunovir, Delimmun, Isoprinosine, Viruxan
Other names	Methisoprinol
AHFS/Drugs.com	https://www.drugs.com/international/isoprinosine-500mg.html
Routes of; administration	Oral
ATC code	J05AX05 (WHO) ;
Legal status
Legal status	In general: ℞ (Prescription only);
Identifiers
PubChem CID	135449284;
ChemSpider	16736312;
KEGG	D01995;
ECHA InfoCard	100.048.313

Inosine pranobex (BAN; also known as inosine acedoben dimepranol (INN) or methisoprinol) is an antiviral drug that is a combination of inosine and dimepranol acedoben (a salt of acetamidobenzoic acid and dimethylaminoisopropanol) in a ratio of 1 to 3. Inosine pranobex has no effect on viral particles itself. Instead, it acts as an immunostimulant, an analog of thymus hormones.^[1] It is most commonly used to treat the rare measles complication subacute sclerosing panencephalitis in conjunction with intrathecal interferon-alpha therapy.^[2]

In the UK, inosine pranobex is also indicated for mucocutaneous infections due to herpes simplex virus (type 1 and type 2) and for treatment of genital warts as adjunctive therapy to podophyllotoxin or carbon dioxide laser.^[3]

References

↑ American Cancer Society. "Inosine Pranobex". Archived from the original on 23 August 2010. Retrieved 31 July 2013.
↑ Campoli-Richards DM, Sorkin EM, Heel RC (Nov 1986). "Inosine pranobex. A preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy". Drugs. 32 (5): 383–424. doi:10.2165/00003495-198632050-00001. PMID 2431857. S2CID 46975349.
↑ "Imunovir 500mg Tablets". UK Electronic Medicines Compendium.

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[1] American Cancer Society. "Inosine Pranobex". Archived from the original on 23 August 2010. Retrieved 31 July 2013.

[2] Campoli-Richards DM, Sorkin EM, Heel RC (Nov 1986). "Inosine pranobex. A preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy". Drugs. 32 (5): 383–424. doi:10.2165/00003495-198632050-00001. PMID 2431857. S2CID 46975349.

[3] "Imunovir 500mg Tablets". UK Electronic Medicines Compendium.

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