Keratosis punctata of the palmar creases
| Keratosis punctata of the palmar creases | |
|---|---|
| Other names: Hyperkeratosis penetrans, Hyperkeratosis punctata, Keratodermia punctata, Keratosis punctata, Keratotic pits of the palmar creases, Lenticular atrophia of the palmar creases, and Punctate keratosis of the palmar creases | |
 | |
| Keratosis punctata of the palmar creases | |
 | |
| Specialty | Dermatology |
| Symptoms | Small depressions in the skin creases of palms and soles, filled with comedo-like keratinous plugs[1] |
| Causes | Inherited (autosomal dominant)[2] |
| Risk factors | African descent[2] |
| Diagnostic method | Appearance[1] |
| Differential diagnosis | Focal acral hyperkeratosis[2] |
| Treatment | Keratolytics, topical retinoids, surgery[2] |
Keratosis punctata of the palmar creases (PKPC) are small (less than 5mm) round depressions in the skin creases of palms, fingers and to a lesser extent the soles, which are filled with comedo-like keratinous plugs.[1] It may appear simultaneously with atopic dermatitis, be associated with manual labour, and worsen by friction.[2] Some are painful.[2]
PKPC runs in families and is inherited as autosomal dominant, most frequently occurring in people of African descent.[2] Diagnosis is by its appearance.[2][3] It may appear similar to focal acral hyperkeratosis.[2]
Applying keratolytics or retinoids may help.[2] Surgically removing them is another option.[2] They likely recur.[2]
The condition was first described by Rasmussen in 1980.[2]
See also
References
- 1 2 3 James, William D.; Elston, Dirk; Treat, James R.; Rosenbach, Misha A.; Neuhaus, Isaac (2020). "11. Pityriasis rosea, pityriasis rubra pilares, and other papulosquamous and hyperkeratotic diseases". Andrews' Diseases of the Skin: Clinical Dermatology (13th ed.). Edinburgh: Elsevier. pp. 209–210. ISBN 978-0-323-54753-6. Archived from the original on 2023-02-27. Retrieved 2023-02-27.
- 1 2 3 4 5 6 7 8 9 10 11 12 13 Hines, Aliya Courtney; Moin, Moin (2020). "2. Common skin conditions in black skin". In Moiin, Ali (ed.). Atlas of Black Skin. Springer. pp. 36–44. ISBN 978-3-030-31484-2. Archived from the original on 2023-02-27. Retrieved 2023-02-27.
- ↑ Thomas, Bjorn R.; O'Toole, Edel A. (25 March 2020). "Diagnosis and Management of Inherited Palmoplantar Keratodermas". Acta Dermato-Venereologica. 100 (7): adv00094. doi:10.2340/00015555-3430. ISSN 1651-2057. PMID 32147745. Archived from the original on 11 April 2022. Retrieved 10 April 2022.
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