Gigantocellular reticular nucleus

Gigantocellular reticular nucleus
Details
Identifiers
Latinnucleus reticularis gigantocellularis
NeuroNames730
NeuroLex IDnlx_anat_1005001
TA98A14.1.04.302
TA26028
FMA72576
Anatomical terms of neuroanatomy

The gigantocellular reticular nucleus (Gi) is a subregion of the medullary reticular formation.[1] As the name indicates, it consists mainly of so-called giant neuronal cells.

This nucleus has been known to innervate the caudal hypoglossal nucleus, and responds to glutamatergic stimuli. The gigantocellular nucleus excites the hypoglossal nucleus, and can play a role in the actions of the said nerve.[2] It additionally receives connections from the periaqueductal gray, the paraventricular hypothalamic nucleus, central nucleus of the amygdala, lateral hypothalamic area, and parvocellular reticular nucleus.

Retrograde studies have shown that the deep mesencephalic reticular formation and oral pontine reticular nucleus project to the gigantocellular nucleus.

The dorsal rostral section of the nucleus reticularis gigantocellularis is also involved in mediating expiration (or out-breathing) along with the parvocellular nucleus.

References

  1. ↑ Ohtake, Toshiyuki (July 1992). "Ascending projections from the gigantocellular reticular and dorsal paragigantocellular nuclei of the medulla oblongata in the rat: an anterograde PHA-L tracing study". Neuroscience Research. 14 (2): 96–116. doi:10.1016/0168-0102(92)90086-R. PMID 1382253.
  2. ↑ Yang, CC et al. Excitatory innervation of caudal hypoglossal nucleus from nucleus reticularis gigantocellularis in the rat. Neuroscience. 1995 Mar;65(2):365-74.

It also receives inputs from the pedunculopontine nucleus.


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