Organification

Organification is a biochemical process that takes place in thyroid gland. It is the incorporation of iodine into thyroglobulin for the production of thyroid hormone, a step done after the oxidation of iodide by the enzyme thyroid peroxidase (TPO).[1] Since iodine is an inorganic compound, and is being attached to thyroglobulin, a protein, the process is termed as "organification of iodine".[2]

Thionamides can block organification.[3]

References

  1. ↑ Comprehensive Pharmacy Review, Leon Shargel, 6th edition, p1181.
  2. ↑ Endocrine Physiology, Patricia E. Molina, third edition, p81.
  3. ↑ Aronson, J. K., ed. (2016-01-01), "Thionamides", Meyler's Side Effects of Drugs (Sixteenth Edition), Oxford: Elsevier, pp. 874–889, doi:10.1016/b978-0-444-53717-1.01537-7, ISBN 978-0-444-53716-4, retrieved 2021-02-18
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