Pseudohypoxia
Pseudohypoxia refers to increased cytosolic ratio of free NAD to NADH in cells, caused by hyperglycemia.[1] Research has shown that declining levels of NAD+ during aging cause pseudohypoxia, and that raising nuclear NAD+ in old mice reverses pseudohypoxia and metabolic dysfunction, thus reversing the aging process.[2] It is expected that human NAD trials will begin in 2014.[3]
Pseudohypoxia is a feature commonly noted in poorly-controlled diabetes.[1]
See also
- Hypoxia (medical)
- Hypoxia (disambiguation) - list under Hypoxia (medical) e.g Intrauterine hypoxia
References
- 1 2 Archived 2018-07-05 at the Wayback Machine Diabetes Magazine: Hyperglycemic Pseudohypoxia and Diabetic Complications, March 12, 1993
- ↑ Archived 2019-09-23 at the Wayback Machine Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging, Cell, Dec 2013
- ↑ Archived 2016-12-21 at the Wayback Machine Guardian Newspaper - Online, Dec 2013
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