Reticulate acropigmentation of Kitamura

Reticulate acropigmentation of Kitamura
Reticulate hyperpigmentation on: a) Dorsa of both hands b) Dorsa of both feet c) Neck d) Axilla
SpecialtyDermatology
SymptomsColored freckle-like and slightly depressed spots arranged in a lace-like pattern on the backs of hands and feet[1]
Usual onsetAdolescence and young adults[1]
CausesAutosomal-dominant[1]
Differential diagnosisDowling–Degos disease[1]
FrequencyRare[1]

Reticulate acropigmentation of Kitamura (RAK), is a type of pigmentation disorder of the skin.[1] It presents with colored freckle-like and slightly depressed spots arranged in a lace-like pattern on the backs of hands and feet.[1] It tends to occur in skin folds of adolescents and early adulthood, and darkens over time.[1]

It is inherited in an autosomal-dominant fashion.[1]

The condition is rare.[2] It was first described in Japan, before recognising that is also occurs elsewhere.[1]

Signs and symptoms

  • Hyperpigmented macules of forearms
    Hyperpigmented macules of forearms
  • Freckle-like marks on back of hands
    Freckle-like marks on back of hands
  • Fine pitting of the palms
    Fine pitting of the palms

Diagnosis

  • Increased melanization of the basal layer with slightly atrophic epidermis (H and E, ×40)
    Increased melanization of the basal layer with slightly atrophic epidermis (H and E, ×40)

Genetics

This condition is associated with mutations in the a disintegrin and metalloproteinase domain-containing protein 10 (ADAM10) gene. This association was first shown in 2013.

See also

References

  1. 1 2 3 4 5 6 7 8 9 10 James, William D.; Elston, Dirk; Treat, James R.; Rosenbach, Misha A.; Neuhaus, Isaac (2020). "36. Disturbances of pigmentation". Andrews' Diseases of the Skin: Clinical Dermatology (13th ed.). Edinburgh: Elsevier. p. 867. ISBN 978-0-323-54753-6. Archived from the original on 2023-07-01. Retrieved 2023-05-04.
  2. ↑ "Orphanet: Reticulate acropigmentation of Kitamura". www.orpha.net. Archived from the original on 25 November 2020. Retrieved 23 April 2019.
Classification
External resources
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