Slow afterhyperpolarization

Slow afterhyperpolarisation (sAHP) refers to prolonged periods of hyperpolarisation in a neuron or cardiomyocyte following an action potential or other depolarising event. In neurons, trains of action potentials may be required to induce sAHPs; this is unlike fast AHPs that require no more than a single action potential. A variety of ionic mechanism may contribute to sAHPs, including potassium efflux from calcium-[1] or sodium-[2] activated potassium channels, and/or the electrogenic response of the sodium-potassium ATPase.[3][4] Depending on neuron type and stimulus used for induction, slow afterhyperpolarisations can last for one second to several tens of seconds, during which time the sAHP effectively inhibits neural activity. Fast and Medium AHPs have shorter durations and different ionic mechanisms.

See also

Afterhyperpolarization

Calcium-activated potassium channel

Sodium-activated potassium channel

Sodium pump

References

  1. ↑ P. Sah, Ca(2+)-activated K+ currents in neurones: types, physiological roles and modulation. Trends in Neurosciences 19:150-154 (1996).
  2. ↑ P. C. Schwindt, W.J. Spain, and W.E. Crill, Long-lasting reduction of excitability by a sodium-dependent potassium current in cat neocortical neurons. Journal of Neurophysiology 61:233-244 (1989).
  3. ↑ J.H. Kim, I. Sizov, M. Dobretsov, and H. Von Gersdorff, Presynaptic Ca2+ buffers control the strength of a fast post-tetanic hyperpolarization mediated by the a3 Na+/K+-ATPase, Nature Neuroscience 10:196-205 (2007).
  4. ↑ A.T. Gulledge, S. Dasari, K. Onoue, E.K. Stephens, J.M. Hasse, and D. Avesar, A sodium-pump-mediated afterhyperpolarization in pyramidal neurons., Journal of Neuroscience 33:13025-13041 (2013).
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