Tohoku Medical Megabank Project

The Tohoku Medical Megabank Project is a national project in Japan.[1] The mission of the Tohoku Medical Megabank (TMM) project is to carry out a long-term health survey in the Miyagi and Iwate prefectures, which were affected by the Great East Japan Earthquake, and provide the research infrastructure for the development of personalized medicine by establishing a biobank and cohort study.[2][3] It started in 2012.

The TMM project is conducted by Tohoku University's Tohoku Medical Megabank Organization (ToMMo) and Iwate Medical University's Iwate Tohoku Medical Megabank Organization (IMM).

Timelines

2013

  • Recruitment of TMM Community-Based Cohort starts.[1]
  • Recruitment of TMM Birth and Three-Generation Cohort Study starts.[1]

2014

  • Japanese genome reference panel (1KJPN), which shows variant allele frequency based on whole genome sequencing of 1070 cohort participants, is released (draft version 2014, official version 2015).[4]
  • Japonica array, a SNP array optimized for Japanese population by taking advantage of 1KJPN haplotype information, is released.[5]

2015

  • A portal site of Japanese Multi Omics Reference Panel (jMorp), providing metabolome and proteome data from the cohort participants, is opened. As of 2022, jMorp covers metabolome, proteome, transcriptome, methylome, as well as genome reference panel.[6]

2016

  • Recruitment of TMM Community-Based Cohort is finished with over 80,000 participants.[1]

2017

  • Recruitment of TMM Birth and Three-Generation Cohort Study is finished with over 70,000 participants.[1]
  • The second followup survey starts.

2018

  • Japanese genome reference panel (3.5KJPNv2), which shows variant allele frequency based on whole genome sequencing of 3554 cohort participants, is released (published in 2019).[7]

2019

  • Japanese reference genome (JG1) is released (published in 2021).[8]
  • Distribution of 67,000 TMM Community-Based Cohort samples data starts.
  • Japanese genome reference panel (4.7KJPN) is released.
  • Japonica array NEO, which is SNP array optimized for Japanese population by taking advantage of 3.5KJPN haplotype information, is released (published in 2021).[9]

2020.

  • Distribution of 54,000 SNP array data starts.
  • Distribution of TMM Birth and Three-Generation Cohort samples data starts.
  • Japanese genome reference panel (8.3KJPN) is released.

2021

  • The third followup survey starts

References

  1. 1 2 3 4 5 Kuriyama, Shinichi; Yaegashi, Nobuo; Nagami, Fuji; Arai, Tomohiko; Kawaguchi, Yoshio; Osumi, Noriko; Sakaida, Masaki; Suzuki, Yoichi; Nakayama, Keiko; Hashizume, Hiroaki; Tamiya, Gen (2016). "The Tohoku Medical Megabank Project: Design and Mission". Journal of Epidemiology. 26 (9): 493–511. doi:10.2188/jea.JE20150268. PMC 5008970. PMID 27374138.
  2. ↑ Minegishi, Naoko; Nishijima, Ichiko; Nobukuni, Takahiro; Kudo, Hisaaki; Ishida, Noriko; Terakawa, Takahiro; Kumada, Kazuki; Yamashita, Riu; Katsuoka, Fumiki; Ogishima, Soichi; Suzuki, Kichiya (2019). "Biobank Establishment and Sample Management in the Tohoku Medical Megabank Project". The Tohoku Journal of Experimental Medicine. 248 (1): 45–55. doi:10.1620/tjem.248.45.
  3. ↑ Kuriyama, Shinichi; Metoki, Hirohito; Kikuya, Masahiro; Obara, Taku; Ishikuro, Mami; Yamanaka, Chizuru; Nagai, Masato; Matsubara, Hiroko; Kobayashi, Tomoko; Sugawara, Junichi; Tamiya, Gen (2020-02-01). "Cohort Profile: Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study): rationale, progress and perspective". International Journal of Epidemiology. 49 (1): 18–19m. doi:10.1093/ije/dyz169. ISSN 0300-5771. PMC 7124511. PMID 31504573.
  4. ↑ Nagasaki, Masao; Yasuda, Jun; Katsuoka, Fumiki; Nariai, Naoki; Kojima, Kaname; Kawai, Yosuke; Yamaguchi-Kabata, Yumi; Yokozawa, Junji; Danjoh, Inaho; Saito, Sakae; Sato, Yukuto (2015-08-21). "Rare variant discovery by deep whole-genome sequencing of 1,070 Japanese individuals". Nature Communications. 6: 8018. doi:10.1038/ncomms9018. ISSN 2041-1723. PMC 4560751. PMID 26292667.
  5. ↑ Kawai, Yosuke; Mimori, Takahiro; Kojima, Kaname; Nariai, Naoki; Danjoh, Inaho; Saito, Rumiko; Yasuda, Jun; Yamamoto, Masayuki; Nagasaki, Masao (October 2015). "Japonica array: improved genotype imputation by designing a population-specific SNP array with 1070 Japanese individuals". Journal of Human Genetics. 60 (10): 581–587. doi:10.1038/jhg.2015.68. ISSN 1434-5161. PMC 4635170. PMID 26108142.
  6. ↑ Tadaka, Shu; Saigusa, Daisuke; Motoike, Ikuko N.; Inoue, Jin; Aoki, Yuichi; Shirota, Matsuyuki; Koshiba, Seizo; Yamamoto, Masayuki; Kinoshita, Kengo (2018-01-04). "jMorp: Japanese Multi Omics Reference Panel". Nucleic Acids Research. 46 (D1): D551–D557. doi:10.1093/nar/gkx978. ISSN 1362-4962. PMC 5753289. PMID 29069501.
  7. ↑ Tadaka, Shu; Katsuoka, Fumiki; Ueki, Masao; Kojima, Kaname; Makino, Satoshi; Saito, Sakae; Otsuki, Akihito; Gocho, Chinatsu; Sakurai-Yageta, Mika; Danjoh, Inaho; Motoike, Ikuko N. (2019). "3.5KJPNv2: an allele frequency panel of 3552 Japanese individuals including the X chromosome". Human Genome Variation. 6: 28. doi:10.1038/s41439-019-0059-5. ISSN 2054-345X. PMC 6581902. PMID 31240104.
  8. ↑ Takayama, Jun; Tadaka, Shu; Yano, Kenji; Katsuoka, Fumiki; Gocho, Chinatsu; Funayama, Takamitsu; Makino, Satoshi; Okamura, Yasunobu; Kikuchi, Atsuo; Sugimoto, Sachiyo; Kawashima, Junko (2021-01-11). "Construction and integration of three de novo Japanese human genome assemblies toward a population-specific reference". Nature Communications. 12 (1): 226. doi:10.1038/s41467-020-20146-8. ISSN 2041-1723. PMC 7801658. PMID 33431880.
  9. ↑ Sakurai-Yageta, Mika; Kumada, Kazuki; Gocho, Chinatsu; Makino, Satoshi; Uruno, Akira; Tadaka, Shu; Motoike, Ikuko N.; Kimura, Masae; Ito, Shin; Otsuki, Akihito; Narita, Akira (2021-10-12). "Japonica Array NEO with increased genome-wide coverage and abundant disease risk SNPs". Journal of Biochemistry. 170 (3): 399–410. doi:10.1093/jb/mvab060. ISSN 1756-2651. PMC 8510329. PMID 34131746.


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