Cinanserin

Cinanserin
Clinical data
ATC code	none;
Identifiers
	IUPAC name (2E)-N-(2-{[3-(dimethylamino)propyl]thio}phenyl)-3-phenylacrylamide;
CAS Number	1166-34-3 ;
PubChem CID	5475158;
ChemSpider	4584027 ;
UNII	KI6J9OY7A3;
ChEBI	CHEBI:145999;
ChEMBL	ChEMBL18786 ;
CompTox Dashboard (EPA)	DTXSID7045653 ;
ECHA InfoCard	100.220.552
Chemical and physical data
Formula	C20H24N2OS
Molar mass	340.49 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CN(C)CCCSC1=CC=CC=C1NC(=O)\C=C\C2=CC=CC=C2;
	InChI InChI=1S/C20H24N2OS/c1-22(2)15-8-16-24-19-12-7-6-11-18(19)21-20(23)14-13-17-9-4-3-5-10-17/h3-7,9-14H,8,15-16H2,1-2H3,(H,21,23)/b14-13+ ; Key:RSUVYMGADVXGOU-BUHFOSPRSA-N ;
	(what is this?) (verify)

Cinanserin (INN) is a 5-HT_2A and 5-HT_2C receptor antagonist which was discovered in the 1960s.^[1]

The molecule is an inhibitor of the 3C-like protease of SARS-coronavirus (SARS).^[2]

References

↑ Neuman RS, Zebrowska G (December 1992). "Serotonin (5-HT2) receptor mediated enhancement of cortical unit activity". Canadian Journal of Physiology and Pharmacology. 70 (12): 1604–9. doi:10.1139/y92-230. PMID 1301238.
↑ Chen L, Gui C, Luo X, Yang Q, Günther S, Scandella E, et al. (June 2005). "Cinanserin is an inhibitor of the 3C-like proteinase of severe acute respiratory syndrome coronavirus and strongly reduces virus replication in vitro". Journal of Virology. 79 (11): 7095–103. doi:10.1128/JVI.79.11.7095-7103.2005. PMC 1112131. PMID 15890949.

This article is issued from Offline. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.