Hydroflumethiazide

Hydroflumethiazide
Clinical data
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ATC code
Identifiers
IUPAC name
  • 1,1-Dioxo-6-(trifluoromethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide
CAS Number
PubChem CID
IUPHAR/BPS
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ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.004.704
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Chemical and physical data
FormulaC8H8F3N3O4S2
Molar mass331.28 g·mol−1
3D model (JSmol)
SMILES
  • FC(F)(F)c2c(cc1c(NCNS1(=O)=O)c2)S(=O)(=O)N
InChI
  • InChI=1S/C8H8F3N3O4S2/c9-8(10,11)4-1-5-7(2-6(4)19(12,15)16)20(17,18)14-3-13-5/h1-2,13-14H,3H2,(H2,12,15,16) checkY
  • Key:DMDGGSIALPNSEE-UHFFFAOYSA-N checkY
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Hydroflumethiazide (or Saluron) is a diuretic.

Synthesis

Hydroflumethiazide synthesis:[1][2][3] Numerous patents, e.g., Lund et al., U.S. Patent 3,254,076 (1966 to Lövens Kemiske Fabrik).

See also

References

  1. ↑ Holdrege CT, Babel RB, Cheney LC (1959). "Synthesis of Trifluoromethylated Compounds Possessing Diuretic Activity1". Journal of the American Chemical Society. 81 (18): 4807–4810. doi:10.1021/ja01527a015.
  2. ↑ Close WJ, Swett LR, Brady LE, Short JH, Vernsten M (1960). "Synthesis of Potential Diuretic Agents. I. Derivatives of 7-Sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-Dioxide". Journal of the American Chemical Society. 82 (5): 1132–1135. doi:10.1021/ja01490a028.
  3. ↑ Novello FC, Bell SC, Abrams EL, Ziegler C, Sprague JM (1960). "Diuretics: 1,2,4-Benzothiadiazine-1,1-dioxides". The Journal of Organic Chemistry. 25 (6): 970–981. doi:10.1021/jo01076a028.


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