عامل النمو المحول بيتا 1

Transforming growth factor, beta 1
	بنك بيانات البروتينات rendering based on 1kla.
التراكيب المتوفرة
بنك بيانات البروتين	بحث أورثولوغ: PDBe, RCSB
قائمة رموز معرفات بنك بيانات البروتين
	1KLA, 1KLC, 1KLD, 3KFD, 4KV5
المعرفات
الرمز، (أو الرموز)	TGFB1; CED; DPD1; LAP; TGFB; TGFbeta
معرفات خارجية	OMIM: 190180 MGI: 98725 هومولوجين: 540 مختبر علم الأحياء الجزيئي الأوروبي الكيميائي: 1795178 بطاقات الجينات: TGFB1 Gene
علم الوجود الجيني
الوظيفة الجزيئية	• glycoprotein binding; • antigen binding; • type II transforming growth factor beta receptor binding; • cytokine activity; • protein binding; • growth factor activity; • enzyme binding; • type I transforming growth factor beta receptor binding; • type III transforming growth factor beta receptor binding; • protein homodimerization activity; • protein heterodimerization activity; • protein N-terminus binding;
المكونات الخلوية	• extracellular region; • proteinaceous extracellular matrix; • extracellular space; • nucleus; • cytoplasm; • Golgi lumen; • plasma membrane; • microvillus; • cell surface; • axon; • platelet alpha granule lumen; • neuronal cell body; • blood microparticle;
العملية الإحيائية	• protein import into nucleus, translocation; • negative regulation of transcription from RNA polymerase II promoter; • MAPK cascade; • ureteric bud development; • response to hypoxia; • epithelial to mesenchymal transition; • negative regulation of protein phosphorylation; • positive regulation of protein phosphorylation; • regulation of sodium ion transport; • chondrocyte differentiation; • hematopoietic progenitor cell differentiation; • connective tissue replacement involved in inflammatory response wound healing; • adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains; • tolerance induction to self antigen; • platelet degranulation; • protein phosphorylation; • protein export from nucleus; • ATP biosynthetic process; • phosphate-containing compound metabolic process; • cellular calcium ion homeostasis; • inflammatory response; • cell cycle arrest; • mitotic cell cycle checkpoint; • epidermal growth factor receptor signaling pathway; • transforming growth factor beta receptor signaling pathway; • common-partner SMAD protein phosphorylation; • SMAD protein complex assembly; • SMAD protein import into nucleus; • negative regulation of neuroblast proliferation; • salivary gland morphogenesis; • endoderm development; • female pregnancy; • aging; • blood coagulation; • negative regulation of DNA replication; • positive regulation of cell proliferation; • negative regulation of cell proliferation; • germ cell migration; • response to radiation; • response to wounding; • response to glucose; • defense response to fungus, incompatible interaction; • positive regulation of vascular endothelial growth factor production; • positive regulation of gene expression; • negative regulation of gene expression; • negative regulation of extracellular matrix disassembly; • positive regulation of epithelial to mesenchymal transition; • macrophage derived foam cell differentiation; • positive regulation of fibroblast migration; • positive regulation of peptidyl-threonine phosphorylation; • positive regulation of pathway-restricted SMAD protein phosphorylation; • negative regulation of macrophage cytokine production; • oligodendrocyte development; • cell growth; • regulation of striated muscle tissue development; • regulation of transforming growth factor beta receptor signaling pathway; • modulation by virus of host morphology or physiology; • evasion or tolerance of host defenses by virus; • viral life cycle; • negative regulation of cell-cell adhesion; • platelet activation; • extracellular matrix organization; • hyaluronan catabolic process; • negative regulation of ossification; • negative regulation of cell growth; • regulation of cell migration; • positive regulation of cell migration; • positive regulation of bone mineralization; • negative regulation of transforming growth factor beta receptor signaling pathway; • positive regulation of histone deacetylation; • organ regeneration; • positive regulation of protein complex assembly; • positive regulation of exit from mitosis; • lipopolysaccharide-mediated signaling pathway; • positive regulation of cellular protein metabolic process; • response to estradiol; • response to progesterone; • regulation of interleukin-23 production; • negative regulation of interleukin-17 production; • positive regulation of interleukin-17 production; • receptor catabolic process; • positive regulation of superoxide anion generation; • mononuclear cell proliferation; • positive regulation of collagen biosynthetic process; • positive regulation of peptidyl-serine phosphorylation; • response to vitamin D; • response to laminar fluid shear stress; • positive regulation of histone acetylation; • positive regulation of protein dephosphorylation; • negative regulation of T cell proliferation; • regulation of protein import into nucleus; • positive regulation of protein import into nucleus; • positive regulation of odontogenesis; • response to drug; • myelination; • regulation of apoptotic process; • myeloid dendritic cell differentiation; • T cell homeostasis; • positive regulation of apoptotic process; • positive regulation of MAP kinase activity; • protein kinase B signaling; • positive regulation of blood vessel endothelial cell migration; • negative regulation of blood vessel endothelial cell migration; • positive regulation of phosphatidylinositol 3-kinase activity; • ossification involved in bone remodeling; • regulatory T cell differentiation; • cell-cell junction organization; • negative regulation of cell differentiation; • negative regulation of fat cell differentiation; • negative regulation of myoblast differentiation; • negative regulation of cell cycle; • negative regulation of transcription, DNA-templated; • positive regulation of transcription, DNA-templated; • negative regulation of mitotic cell cycle; • positive regulation of transcription from RNA polymerase II promoter; • active induction of host immune response by virus; • positive regulation of isotype switching to IgA isotypes; • cell development; • lymph node development; • digestive tract development; • negative regulation of skeletal muscle tissue development; • inner ear development; • positive regulation of epithelial cell proliferation; • negative regulation of epithelial cell proliferation; • positive regulation of protein secretion; • negative regulation of phagocytosis; • positive regulation of chemotaxis; • positive regulation of NF-kappaB transcription factor activity; • regulation of binding; • regulation of DNA binding; • positive regulation of smooth muscle cell differentiation; • negative regulation of release of sequestered calcium ion into cytosol; • positive regulation of protein kinase B signaling; • regulation of blood vessel remodeling; • face morphogenesis; • frontal suture morphogenesis; • pathway-restricted SMAD protein phosphorylation; • positive regulation of SMAD protein import into nucleus; • SMAD protein signal transduction; • mammary gland branching involved in thelarche; • branch elongation involved in mammary gland duct branching; • regulation of branching involved in mammary gland duct morphogenesis; • negative regulation of gene silencing by miRNA; • regulation of cartilage development; • lens fiber cell differentiation; • response to cholesterol; • positive regulation of cell cycle arrest; • cellular response to organic cyclic compound; • cellular response to dexamethasone stimulus; • cellular response to transforming growth factor beta stimulus; • extracellular matrix assembly; • positive regulation of branching involved in ureteric bud morphogenesis; • extrinsic apoptotic signaling pathway; • negative regulation of hyaluronan biosynthetic process; • positive regulation of extracellular matrix assembly; • positive regulation of NAD+ ADP-ribosyltransferase activity; • regulation of actin cytoskeleton reorganization; • positive regulation of transcription regulatory region DNA binding;
	المصادر: Amigo / QuickGO
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التقويمات

عامل النمو المحول بيتا 1 (TGF-β1) هو بروتين يتبع عائلة عامل النمو المحول التابعة لمجموعة السيتوكين. يساهم هذه البروتين في عدد من الوظائف الخلوية مثل تكاثر ونمو الخلايا والتمايز الخلوي والااستماتة.[1][2]

انظر أيضًا

عامل النمو المحول بيتا

مصادر

Ghadami M, Makita Y, Yoshida K, Nishimura G, Fukushima Y, Wakui K, Ikegawa S, Yamada K, Kondo S, Niikawa N, Tomita Ha (يناير 2000)، "Genetic mapping of the Camurati-Engelmann disease locus to chromosome 19q13.1-q13.3"، Am. J. Hum. Genet.، 66 (1): 143–7، doi:10.1086/302728، PMC 1288319، PMID 10631145.
Vaughn SP, Broussard S, Hall CR, Scott A, Blanton SH, Milunsky JM, Hecht JT (مايو 2000)، "Confirmation of the mapping of the Camurati-Englemann locus to 19q13. 2 and refinement to a 3.2-cM region"، Genomics، 66 (1): 119–21، doi:10.1006/geno.2000.6192، PMID 10843814.

بوابة الكيمياء الحيوية

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[pmid10631145-1] Ghadami M, Makita Y, Yoshida K, Nishimura G, Fukushima Y, Wakui K, Ikegawa S, Yamada K, Kondo S, Niikawa N, Tomita Ha (يناير 2000)، "Genetic mapping of the Camurati-Engelmann disease locus to chromosome 19q13.1-q13.3"، Am. J. Hum. Genet.، 66 (1): 143–7، doi:10.1086/302728، PMC 1288319، PMID 10631145.

[pmid10843814-2] Vaughn SP, Broussard S, Hall CR, Scott A, Blanton SH, Milunsky JM, Hecht JT (مايو 2000)، "Confirmation of the mapping of the Camurati-Englemann locus to 19q13. 2 and refinement to a 3.2-cM region"، Genomics، 66 (1): 119–21، doi:10.1006/geno.2000.6192، PMID 10843814.