مستقبل حمض الريتينويك ألفا

مستقبل حمض الريتينويك ألفا
المعرفات
الرمز	RARA
Ensembl Transcript ID	ENST00000582914; ENST00000254066; ENST00000394081; ENST00000394086; ENST00000394089; ENST00000420042; ENST00000425707; ENST00000475125; ENST00000577646; ENST00000579727
Ensembl Gene ID	ENSG00000131759
أنتريه	5914
HUGO	9864
أوميم	180240
هومولوجين	20262
RefSeq	NM_000964
يونيبروت	P10276
بيانات أخرى
الموقع الكروموسومي	Chr. 17 q21.1

Retinoic acid receptor, alpha
	بنك بيانات البروتينات rendering based on 1dkf.
التراكيب المتوفرة
بنك بيانات البروتين	بحث أورثولوغ: PDBe, RCSB
قائمة رموز معرفات بنك بيانات البروتين
	1DKF, 1DSZ, 3A9E, 3KMR, 3KMZ, 4DQM
المعرفات
الرمز، (أو الرموز)	RARA; NR1B1; RAR
معرفات خارجية	OMIM: 180240 MGI: 97856 هومولوجين: 20262 الاتحاد الدولي للصيدلة الأساسية والسريرية: 590 مختبر علم الأحياء الجزيئي الأوروبي الكيميائي: 2055 بطاقات الجينات: RARA Gene
علم الوجود الجيني
الوظيفة الجزيئية	• RNA polymerase II regulatory region sequence-specific DNA binding; • retinoic acid binding; • transcription factor activity, sequence-specific DNA binding; • steroid hormone receptor activity; • retinoic acid receptor activity; • transcription coactivator activity; • transcription corepressor activity; • receptor binding; • protein binding; • transcription factor binding; • zinc ion binding; • enzyme binding; • protein domain specific binding; • chromatin DNA binding; • protein kinase B binding; • retinoic acid-responsive element binding; • protein heterodimerization activity; • protein kinase A binding; • alpha-actinin binding;
المكونات الخلوية	• nuclear chromatin; • nucleus; • nucleoplasm; • cytoplasm; • cell surface; • actin cytoskeleton; • dendrite; • neuronal cell body;
العملية الإحيائية	• negative regulation of transcription from RNA polymerase II promoter; • ureteric bud development; • neural tube closure; • glandular epithelial cell development; • outflow tract septum morphogenesis; • growth plate cartilage development; • transcription initiation from RNA polymerase II promoter; • protein phosphorylation; • signal transduction; • germ cell development; • spermatogenesis; • positive regulation of cell proliferation; • gene expression; • negative regulation of granulocyte differentiation; • embryonic camera-type eye development; • response to retinoic acid; • negative regulation of interferon-gamma production; • negative regulation of tumor necrosis factor production; • positive regulation of interleukin-13 production; • positive regulation of interleukin-4 production; • positive regulation of interleukin-5 production; • multicellular organism growth; • negative regulation of apoptotic process; • apoptotic cell clearance; • steroid hormone mediated signaling pathway; • positive regulation of T-helper 2 cell differentiation; • positive regulation of cell cycle; • negative regulation of transcription, DNA-templated; • positive regulation of transcription, DNA-templated; • positive regulation of transcription from RNA polymerase II promoter; • negative regulation of translational initiation; • retinoic acid receptor signaling pathway; • positive regulation of binding; • ventricular cardiac muscle cell differentiation; • Sertoli cell fate commitment; • limb development; • face development; • trachea cartilage development; • chondroblast differentiation; • negative regulation of cartilage development; • cellular response to lipopolysaccharide; • cellular response to retinoic acid; • cellular response to estrogen stimulus;
	المصادر: Amigo / QuickGO
نمط التعبير عن الحمض النووي الريبوزي
	مصادر أخرى عن بيانات أنماط التعبير
التقويمات

مستقبل حمض الريتنويك ألفا (بالإنجليزية: Retinoic acid receptor alpha)‏ (ومختصره RAR-α)، كما يعرف باسم المستقبل النووي عائلة 1، مجموعة ب، عضو 1 (بالإنجليزية: nuclear receptor subfamily 1, group B, member 1)‏ (ومختصره NR1B1) هو مستقبل نووي موجود عند الإنسان ومشفر بالمورثة RARA.[1][2]

التفاعلات

أظهر مستقبل حمض الريتنويك ألفا ثآثرات مع:

BAG1,[3]
CLOCK,[4]
CCND3,[5]
NCOA6,[6][7][8]
NCOR1,[9][10]
NCOR2,[11][12]
NPAS2,[4]
NRIP1,[13][14][15]
NR0B2,[16][17]
NR4A2,[18]
PML[19]
RXRA.[20][21]
Src,[22][23]
TADA3L,[24]
ZBTB16.[25]

طالع أيضا

مستقبل حمض الريتنويك

المصادر

Giguere V, Ong ES, Segui P, Evans RM (1987)، "Identification of a receptor for the morphogen retinoic acid"، Nature، 330 (6149): 624–9، doi:10.1038/330624a0، PMID 2825036.
Anderson LA, Friedman L, Osborne-Lawrence S, Lynch E, Weissenbach J, Bowcock A, King MC (سبتمبر 1993)، "High-density genetic map of the BRCA1 region of chromosome 17q12-q21"، Genomics، 17 (3): 618–23، doi:10.1006/geno.1993.1381، PMID 8244378.
Liu R, Takayama S, Zheng Y, Froesch B, Chen GQ, Zhang X, Reed JC, Zhang XK (يوليو 1998)، "Interaction of BAG-1 with retinoic acid receptor and its inhibition of retinoic acid-induced apoptosis in cancer cells"، J. Biol. Chem.، 273 (27): 16985–92، doi:10.1074/jbc.273.27.16985، PMID 9642262.
McNamara P, Seo SB, Rudic RD, Sehgal A, Chakravarti D, FitzGerald GA (يونيو 2001)، "Regulation of CLOCK and MOP4 by nuclear hormone receptors in the vasculature: a humoral mechanism to reset a peripheral clock"، Cell، 105 (7): 877–89، doi:10.1016/S0092-8674(01)00401-9، PMID 11439184.
Despouy G, Bastie JN, Deshaies S, Balitrand N, Mazharian A, Rochette-Egly C, Chomienne C, Delva L (فبراير 2003)، "Cyclin D3 is a cofactor of retinoic acid receptors, modulating their activity in the presence of cellular retinoic acid-binding protein II"، J. Biol. Chem.، 278 (8): 6355–62، doi:10.1074/jbc.M210697200، PMID 12482873.
Lee SK, Jung SY, Kim YS, Na SY, Lee YC, Lee JW (فبراير 2001)، "Two distinct nuclear receptor-interaction domains and CREB-binding protein-dependent transactivation function of activating signal cointegrator-2"، Mol. Endocrinol.، 15 (2): 241–54، doi:10.1210/me.15.2.241، PMID 11158331.
Lee SK, Anzick SL, Choi JE, Bubendorf L, Guan XY, Jung YK, Kallioniemi OP, Kononen J, Trent JM, Azorsa D, Jhun BH, Cheong JH, Lee YC, Meltzer PS, Lee JW (نوفمبر 1999)، "A nuclear factor, ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo"، J. Biol. Chem.، 274 (48): 34283–93، doi:10.1074/jbc.274.48.34283، PMID 10567404.
Ko L, Cardona GR, Chin WW (مايو 2000)، "Thyroid hormone receptor-binding protein, an LXXLL motif-containing protein, functions as a general coactivator"، Proc. Natl. Acad. Sci. U.S.A.، 97 (11): 6212–7، doi:10.1073/pnas.97.11.6212، PMC 18584، PMID 10823961.
Dowell P, Ishmael JE, Avram D, Peterson VJ, Nevrivy DJ, Leid M (مايو 1999)، "Identification of nuclear receptor corepressor as a peroxisome proliferator-activated receptor alpha interacting protein"، J. Biol. Chem.، 274 (22): 15901–7، doi:10.1074/jbc.274.22.15901، PMID 10336495.
Guidez F, Ivins S, Zhu J, Söderström M, Waxman S, Zelent A (أبريل 1998)، "Reduced retinoic acid-sensitivities of nuclear receptor corepressor binding to PML- and PLZF-RARalpha underlie molecular pathogenesis and treatment of acute promyelocytic leukemia"، Blood، 91 (8): 2634–42، PMID 9531570.
Dong S, Tweardy DJ (أبريل 2002)، "Interactions of STAT5b-RARalpha, a novel acute promyelocytic leukemia fusion protein, with retinoic acid receptor and STAT3 signaling pathways"، Blood، 99 (8): 2637–46، doi:10.1182/blood.V99.8.2637، PMID 11929748.
Hong SH, David G, Wong CW, Dejean A, Privalsky ML (أغسطس 1997)، "SMRT corepressor interacts with PLZF and with the PML-retinoic acid receptor alpha (RARalpha) and PLZF-RARalpha oncoproteins associated with acute promyelocytic leukemia"، Proc. Natl. Acad. Sci. U.S.A.، 94 (17): 9028–33، doi:10.1073/pnas.94.17.9028، PMC 23013، PMID 9256429.
Hu X, Chen Y, Farooqui M, Thomas MC, Chiang CM, Wei LN (يناير 2004)، "Suppressive effect of receptor-interacting protein 140 on coregulator binding to retinoic acid receptor complexes, histone-modifying enzyme activity, and gene activation"، J. Biol. Chem.، 279 (1): 319–25، doi:10.1074/jbc.M307621200، PMID 14581481.
Farooqui M, Franco PJ, Thompson J, Kagechika H, Chandraratna RA, Banaszak L, Wei LN (فبراير 2003)، "Effects of retinoid ligands on RIP140: molecular interaction with retinoid receptors and biological activity"، Biochemistry، 42 (4): 971–9، doi:10.1021/bi020497k، PMID 12549917.
L'Horset F, Dauvois S, Heery DM, Cavaillès V, Parker MG (نوفمبر 1996)، "RIP-140 interacts with multiple nuclear receptors by means of two distinct sites"، Mol. Cell. Biol.، 16 (11): 6029–36، PMC 231605، PMID 8887632.
Seol W, Choi HS, Moore DD (مايو 1996)، "An orphan nuclear hormone receptor that lacks a DNA binding domain and heterodimerizes with other receptors"، Science، 272 (5266): 1336–9، doi:10.1126/science.272.5266.1336، PMID 8650544.
Seol W, Hanstein B, Brown M, Moore DD (أكتوبر 1998)، "Inhibition of estrogen receptor action by the orphan receptor SHP (short heterodimer partner)"، Mol. Endocrinol.، 12 (10): 1551–7، doi:10.1210/me.12.10.1551، PMID 9773978.
Perlmann T, Jansson L (أبريل 1995)، "A novel pathway for vitamin A signaling mediated by RXR heterodimerization with NGFI-B and NURR1"، Genes Dev.، 9 (7): 769–82، doi:10.1101/gad.9.7.769، PMID 7705655.
Zhong S, Delva L, Rachez C, Cenciarelli C, Gandini D, Zhang H, Kalantry S, Freedman LP, Pandolfi PP (نوفمبر 1999)، "A RA-dependent, tumour-growth suppressive transcription complex is the target of the PML-RARalpha and T18 oncoproteins"، Nat. Genet.، 23 (3): 287–95، doi:10.1038/15463، PMID 10610177.
Benkoussa M, Brand C, Delmotte MH, Formstecher P, Lefebvre P (يوليو 2002)، "Retinoic acid receptors inhibit AP1 activation by regulating extracellular signal-regulated kinase and CBP recruitment to an AP1-responsive promoter"، Mol. Cell. Biol.، 22 (13): 4522–34، doi:10.1128/MCB.22.13.4522-4534.2002، PMC 133906، PMID 12052862.
Bugge TH, Pohl J, Lonnoy O, Stunnenberg HG (أبريل 1992)، "RXR alpha, a promiscuous partner of retinoic acid and thyroid hormone receptors"، EMBO J.، 11 (4): 1409–18، PMC 556590، PMID 1314167.
Kim HJ, Yi JY, Sung HS, Moore DD, Jhun BH, Lee YC, Lee JW (سبتمبر 1999)، "Activating signal cointegrator 1, a novel transcription coactivator of nuclear receptors, and its cytosolic localization under conditions of serum deprivation"، Mol. Cell. Biol.، 19 (9): 6323–32، PMC 84603، PMID 10454579.
He B, Wilson EM (مارس 2003)، "Electrostatic modulation in steroid receptor recruitment of LXXLL and FXXLF motifs"، Mol. Cell. Biol.، 23 (6): 2135–50، doi:10.1128/MCB.23.6.2135-2150.2003، PMC 149467، PMID 12612084.
Zeng M, Kumar A, Meng G, Gao Q, Dimri G, Wazer D, Band H, Band V (نوفمبر 2002)، "Human papilloma virus 16 E6 oncoprotein inhibits retinoic X receptor-mediated transactivation by targeting human ADA3 coactivator"، J. Biol. Chem.، 277 (47): 45611–8، doi:10.1074/jbc.M208447200، PMID 12235159.
Martin PJ, Delmotte MH, Formstecher P, Lefebvre P (سبتمبر 2003)، "PLZF is a negative regulator of retinoic acid receptor transcriptional activity"، Nucl. Recept.، 1 (1): 6، doi:10.1186/1478-1336-1-6، PMC 212040، PMID 14521715.

بوابة علم الأحياء الخلوي والجزيئي
بوابة الكيمياء الحيوية

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[pmid2825036-1] Giguere V, Ong ES, Segui P, Evans RM (1987)، "Identification of a receptor for the morphogen retinoic acid"، Nature، 330 (6149): 624–9، doi:10.1038/330624a0، PMID 2825036.

[pmid8244378-2] Anderson LA, Friedman L, Osborne-Lawrence S, Lynch E, Weissenbach J, Bowcock A, King MC (سبتمبر 1993)، "High-density genetic map of the BRCA1 region of chromosome 17q12-q21"، Genomics، 17 (3): 618–23، doi:10.1006/geno.1993.1381، PMID 8244378.

[pmid9642262-3] Liu R, Takayama S, Zheng Y, Froesch B, Chen GQ, Zhang X, Reed JC, Zhang XK (يوليو 1998)، "Interaction of BAG-1 with retinoic acid receptor and its inhibition of retinoic acid-induced apoptosis in cancer cells"، J. Biol. Chem.، 273 (27): 16985–92، doi:10.1074/jbc.273.27.16985، PMID 9642262.

[pmid11439184-4] McNamara P, Seo SB, Rudic RD, Sehgal A, Chakravarti D, FitzGerald GA (يونيو 2001)، "Regulation of CLOCK and MOP4 by nuclear hormone receptors in the vasculature: a humoral mechanism to reset a peripheral clock"، Cell، 105 (7): 877–89، doi:10.1016/S0092-8674(01)00401-9، PMID 11439184.

[pmid12482873-5] Despouy G, Bastie JN, Deshaies S, Balitrand N, Mazharian A, Rochette-Egly C, Chomienne C, Delva L (فبراير 2003)، "Cyclin D3 is a cofactor of retinoic acid receptors, modulating their activity in the presence of cellular retinoic acid-binding protein II"، J. Biol. Chem.، 278 (8): 6355–62، doi:10.1074/jbc.M210697200، PMID 12482873.

[pmid11158331-6] Lee SK, Jung SY, Kim YS, Na SY, Lee YC, Lee JW (فبراير 2001)، "Two distinct nuclear receptor-interaction domains and CREB-binding protein-dependent transactivation function of activating signal cointegrator-2"، Mol. Endocrinol.، 15 (2): 241–54، doi:10.1210/me.15.2.241، PMID 11158331.

[pmid10567404-7] Lee SK, Anzick SL, Choi JE, Bubendorf L, Guan XY, Jung YK, Kallioniemi OP, Kononen J, Trent JM, Azorsa D, Jhun BH, Cheong JH, Lee YC, Meltzer PS, Lee JW (نوفمبر 1999)، "A nuclear factor, ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo"، J. Biol. Chem.، 274 (48): 34283–93، doi:10.1074/jbc.274.48.34283، PMID 10567404.

[pmid10823961-8] Ko L, Cardona GR, Chin WW (مايو 2000)، "Thyroid hormone receptor-binding protein, an LXXLL motif-containing protein, functions as a general coactivator"، Proc. Natl. Acad. Sci. U.S.A.، 97 (11): 6212–7، doi:10.1073/pnas.97.11.6212، PMC 18584، PMID 10823961.

[pmid10336495-9] Dowell P, Ishmael JE, Avram D, Peterson VJ, Nevrivy DJ, Leid M (مايو 1999)، "Identification of nuclear receptor corepressor as a peroxisome proliferator-activated receptor alpha interacting protein"، J. Biol. Chem.، 274 (22): 15901–7، doi:10.1074/jbc.274.22.15901، PMID 10336495.

[pmid9531570-10] Guidez F, Ivins S, Zhu J, Söderström M, Waxman S, Zelent A (أبريل 1998)، "Reduced retinoic acid-sensitivities of nuclear receptor corepressor binding to PML- and PLZF-RARalpha underlie molecular pathogenesis and treatment of acute promyelocytic leukemia"، Blood، 91 (8): 2634–42، PMID 9531570.

[pmid11929748-11] Dong S, Tweardy DJ (أبريل 2002)، "Interactions of STAT5b-RARalpha, a novel acute promyelocytic leukemia fusion protein, with retinoic acid receptor and STAT3 signaling pathways"، Blood، 99 (8): 2637–46، doi:10.1182/blood.V99.8.2637، PMID 11929748.

[pmid9256429-12] Hong SH, David G, Wong CW, Dejean A, Privalsky ML (أغسطس 1997)، "SMRT corepressor interacts with PLZF and with the PML-retinoic acid receptor alpha (RARalpha) and PLZF-RARalpha oncoproteins associated with acute promyelocytic leukemia"، Proc. Natl. Acad. Sci. U.S.A.، 94 (17): 9028–33، doi:10.1073/pnas.94.17.9028، PMC 23013، PMID 9256429.

[pmid14581481-13] Hu X, Chen Y, Farooqui M, Thomas MC, Chiang CM, Wei LN (يناير 2004)، "Suppressive effect of receptor-interacting protein 140 on coregulator binding to retinoic acid receptor complexes, histone-modifying enzyme activity, and gene activation"، J. Biol. Chem.، 279 (1): 319–25، doi:10.1074/jbc.M307621200، PMID 14581481.

[pmid12549917-14] Farooqui M, Franco PJ, Thompson J, Kagechika H, Chandraratna RA, Banaszak L, Wei LN (فبراير 2003)، "Effects of retinoid ligands on RIP140: molecular interaction with retinoid receptors and biological activity"، Biochemistry، 42 (4): 971–9، doi:10.1021/bi020497k، PMID 12549917.

[pmid8887632-15] L'Horset F, Dauvois S, Heery DM, Cavaillès V, Parker MG (نوفمبر 1996)، "RIP-140 interacts with multiple nuclear receptors by means of two distinct sites"، Mol. Cell. Biol.، 16 (11): 6029–36، PMC 231605، PMID 8887632.

[pmid8650544-16] Seol W, Choi HS, Moore DD (مايو 1996)، "An orphan nuclear hormone receptor that lacks a DNA binding domain and heterodimerizes with other receptors"، Science، 272 (5266): 1336–9، doi:10.1126/science.272.5266.1336، PMID 8650544.

[pmid9773978-17] Seol W, Hanstein B, Brown M, Moore DD (أكتوبر 1998)، "Inhibition of estrogen receptor action by the orphan receptor SHP (short heterodimer partner)"، Mol. Endocrinol.، 12 (10): 1551–7، doi:10.1210/me.12.10.1551، PMID 9773978.

[pmid7705655-18] Perlmann T, Jansson L (أبريل 1995)، "A novel pathway for vitamin A signaling mediated by RXR heterodimerization with NGFI-B and NURR1"، Genes Dev.، 9 (7): 769–82، doi:10.1101/gad.9.7.769، PMID 7705655.

[pmid10610177-19] Zhong S, Delva L, Rachez C, Cenciarelli C, Gandini D, Zhang H, Kalantry S, Freedman LP, Pandolfi PP (نوفمبر 1999)، "A RA-dependent, tumour-growth suppressive transcription complex is the target of the PML-RARalpha and T18 oncoproteins"، Nat. Genet.، 23 (3): 287–95، doi:10.1038/15463، PMID 10610177.

[pmid12052862-20] Benkoussa M, Brand C, Delmotte MH, Formstecher P, Lefebvre P (يوليو 2002)، "Retinoic acid receptors inhibit AP1 activation by regulating extracellular signal-regulated kinase and CBP recruitment to an AP1-responsive promoter"، Mol. Cell. Biol.، 22 (13): 4522–34، doi:10.1128/MCB.22.13.4522-4534.2002، PMC 133906، PMID 12052862.

[pmid1314167-21] Bugge TH, Pohl J, Lonnoy O, Stunnenberg HG (أبريل 1992)، "RXR alpha, a promiscuous partner of retinoic acid and thyroid hormone receptors"، EMBO J.، 11 (4): 1409–18، PMC 556590، PMID 1314167.

[pmid10454579-22] Kim HJ, Yi JY, Sung HS, Moore DD, Jhun BH, Lee YC, Lee JW (سبتمبر 1999)، "Activating signal cointegrator 1, a novel transcription coactivator of nuclear receptors, and its cytosolic localization under conditions of serum deprivation"، Mol. Cell. Biol.، 19 (9): 6323–32، PMC 84603، PMID 10454579.

[pmid12612084-23] He B, Wilson EM (مارس 2003)، "Electrostatic modulation in steroid receptor recruitment of LXXLL and FXXLF motifs"، Mol. Cell. Biol.، 23 (6): 2135–50، doi:10.1128/MCB.23.6.2135-2150.2003، PMC 149467، PMID 12612084.

[pmid12235159-24] Zeng M, Kumar A, Meng G, Gao Q, Dimri G, Wazer D, Band H, Band V (نوفمبر 2002)، "Human papilloma virus 16 E6 oncoprotein inhibits retinoic X receptor-mediated transactivation by targeting human ADA3 coactivator"، J. Biol. Chem.، 277 (47): 45611–8، doi:10.1074/jbc.M208447200، PMID 12235159.

[pmid14521715-25] Martin PJ, Delmotte MH, Formstecher P, Lefebvre P (سبتمبر 2003)، "PLZF is a negative regulator of retinoic acid receptor transcriptional activity"، Nucl. Recept.، 1 (1): 6، doi:10.1186/1478-1336-1-6، PMC 212040، PMID 14521715.