TREM2

TREM2
المعرفات
الأسماء المستعارة	TREM2, TREM-2, Trem2a, Trem2b, Trem2c, triggering receptor expressed on myeloid cells 2, PLOSL2
معرفات خارجية	الوراثة المندلية البشرية عبر الإنترنت 605086 MGI: MGI:1913150 HomoloGene: 10352 GeneCards: 54209
علم الوجود الجيني
الوظيفة الجزيئية	• scaffold protein binding; • lipopolysaccharide binding; • lipoteichoic acid binding; • peptidoglycan binding; • phospholipid binding; • signaling receptor activity; • amyloid-beta binding; • high-density lipoprotein particle binding; • lipid binding; • low-density lipoprotein particle binding; • apolipoprotein binding; • apolipoprotein A-I binding; • very-low-density lipoprotein particle binding; • ‏GO:0032403 protein-containing complex binding; • lipoprotein particle binding; • protein tyrosine kinase binding; • ‏GO:0001948، ‏GO:0016582 ربط بروتيني;
المكونات الخلوية	• مكون تكاملي للغشاء; • غشاء; • منطقة خارج الخلية; • غشاء خلوي; • integral component of plasma membrane; • intrinsic component of plasma membrane;
العمليات الحيوية	• dendritic cell differentiation; • positive regulation of CD40 signaling pathway; • positive regulation of calcium-mediated signaling; • positive regulation of C-C chemokine receptor CCR7 signaling pathway; • phagocytosis, engulfment; • detection of peptidoglycan; • humoral immune response; • cellular response to lipoteichoic acid; • positive regulation of protein localization to plasma membrane; • regulation of immune response; • positive regulation of peptidyl-tyrosine phosphorylation; • detection of lipoteichoic acid; • مناعة فطرية; • detection of lipopolysaccharide; • cellular response to peptidoglycan; • positive regulation of antigen processing and presentation of peptide antigen via MHC class II; • positive regulation of ERK1 and ERK2 cascade; • ‏GO:0072468 توصيل الإشارة; • osteoclast differentiation; • positive regulation of macrophage fusion; • positive regulation of amyloid-beta clearance; • positive regulation of protein phosphorylation; • تنظيم التعبير الجيني; • negative regulation of autophagy; • ‏GO:1901313 positive regulation of gene expression; • positive regulation of mitochondrion organization; • regulation of TOR signaling; • positive regulation of TOR signaling; • regulation of interleukin-6 production; • regulation of peptidyl-tyrosine phosphorylation; • positive regulation of chemotaxis; • regulation of resting membrane potential; • positive regulation of astrocyte activation; • regulation of macrophage inflammatory protein 1 alpha production; • import into cell; • regulation of plasma membrane bounded cell projection organization; • positive regulation of proteasomal protein catabolic process; • positive regulation of inward rectifier potassium channel activity; • regulation of intracellular signal transduction; • positive regulation of microglial cell activation; • negative regulation of autophagic cell death; • positive regulation of microglial cell migration; • cellular response to amyloid-beta; • positive regulation of CAMKK-AMPK signaling cascade; • positive regulation of ATP biosynthetic process; • apoptotic cell clearance; • positive regulation of protein secretion; • microglial cell activation; • response to ischemia; • negative regulation of interleukin-1 beta production; • negative regulation of tumor necrosis factor production; • positive regulation of interleukin-10 production; • negative regulation of apoptotic process; • positive regulation of osteoclast differentiation; • positive regulation of NIK/NF-kappaB signaling; • microglial cell activation involved in immune response; • defense response to bacterium; • regulation of innate immune response; • positive regulation of phagocytosis, engulfment; • microglial cell proliferation; • amyloid-beta clearance; • complement-mediated synapse pruning; • neuroinflammatory response; • positive regulation of neuroinflammatory response; • positive regulation of engulfment of apoptotic cell;
	المصادر:Amigo / QuickGO
نمط التعبير عن الحمض النووي الريبوزي
	المزيد من بيانات التعبير المرجعية
أورثولوج
	Q9NZC2
	Q99NH8
	‏NM_018965 NM_001271821، ‏NM_018965
	‏NM_031254 NM_001272078، ‏NM_031254
	‏NP_061838 NP_001258750، ‏NP_061838
	‏NP_112544 NP_001259007، ‏NP_112544
	ويكي بيانات
اعرض/عدّل إنسان	اعرض/عدّل فأر

TREM2 (اختصارًا لاسم Triggering receptor expressed on myeloid cells 2) هو بروتين في البشر يُشفر عبر جين TREM2.[1][2][3]

المراجع

Bouchon A, Dietrich J, Colonna M (مايو 2000)، "Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes"، Journal of Immunology، 164 (10): 4991–5، doi:10.4049/jimmunol.164.10.4991، PMID 10799849.
Paloneva J, Manninen T, Christman G, Hovanes K, Mandelin J, Adolfsson R, Bianchin M, Bird T, Miranda R, Salmaggi A, Tranebjaerg L, Konttinen Y, Peltonen L (سبتمبر 2002)، "Mutations in two genes encoding different subunits of a receptor signaling complex result in an identical disease phenotype"، American Journal of Human Genetics، 71 (3): 656–62، doi:10.1086/342259، PMC 379202، PMID 12080485.
"Entrez Gene: TREM2 triggering receptor expressed on myeloid cells 2"، مؤرشف من الأصل في 07 مارس 2010.

بوابة طب
بوابة علم الأحياء الخلوي والجزيئي

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[pmid10799849-1] Bouchon A, Dietrich J, Colonna M (مايو 2000)، "Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes"، Journal of Immunology، 164 (10): 4991–5، doi:10.4049/jimmunol.164.10.4991، PMID 10799849.

[pmid12080485-2] Paloneva J, Manninen T, Christman G, Hovanes K, Mandelin J, Adolfsson R, Bianchin M, Bird T, Miranda R, Salmaggi A, Tranebjaerg L, Konttinen Y, Peltonen L (سبتمبر 2002)، "Mutations in two genes encoding different subunits of a receptor signaling complex result in an identical disease phenotype"، American Journal of Human Genetics، 71 (3): 656–62، doi:10.1086/342259، PMC 379202، PMID 12080485.

[entrez-3] "Entrez Gene: TREM2 triggering receptor expressed on myeloid cells 2"، مؤرشف من الأصل في 07 مارس 2010.

التصنيفات الطبية	OMIM ID: 605086
المعرفات الخارجية	Ensembl Transcript ID: ENST00000373122, ENST00000338469, ENST00000373113