(6-4)DNA photolyase

(6-4)DNA photolyase (EC 4.1.99.13, DNA photolyase, H64PRH, NF-10, phr (6-4), PL-(6-4), OtCPF1, (6-4) PHR, At64PHR) is an enzyme with systematic name (6-4) photoproduct pyrimidine-lyase.[1][2] This enzyme catalyses the following chemical reaction

(6-4) photoproduct (in DNA) 2 pyrimidine residues (in DNA)
(6-4)DNA photolyase
Identifiers
EC no.4.1.99.13
CAS no.37290-70-3
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Search
PMCarticles
PubMedarticles
NCBIproteins

This enzyme is a flavoprotein.

References

  1. Hitomi K, DiTacchio L, Arvai AS, Yamamoto J, Kim ST, Todo T, Tainer JA, Iwai S, Panda S, Getzoff ED (April 2009). "Functional motifs in the (6-4) photolyase crystal structure make a comparative framework for DNA repair photolyases and clock cryptochromes". Proceedings of the National Academy of Sciences of the United States of America. 106 (17): 6962–7. Bibcode:2009PNAS..106.6962H. doi:10.1073/pnas.0809180106. PMC 2678464. PMID 19359474.
  2. Schleicher E, Hitomi K, Kay CW, Getzoff ED, Todo T, Weber S (February 2007). "Electron nuclear double resonance differentiates complementary roles for active site histidines in (6-4) photolyase". The Journal of Biological Chemistry. 282 (7): 4738–47. doi:10.1074/jbc.m604734200. PMID 17164245.
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