2-acetolactate mutase

In enzymology, a 2-acetolactate mutase (EC 5.4.99.3) is an enzyme that catalyzes the chemical reaction

2-acetolactate 3-hydroxy-3-methyl-2-oxobutanoate
2-acetolactate mutase
Identifiers
EC no.5.4.99.3
CAS no.37318-52-8
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins

Hence, this enzyme has one substrate, 2-acetolactate, and one product, 3-hydroxy-3-methyl-2-oxobutanoate.

This enzyme belongs to the family of isomerases, specifically those intramolecular transferases transferring other groups. The systematic name of this enzyme class is 2-acetolactate methylmutase. Other names in common use include acetolactate mutase, and acetohydroxy acid isomerase. This enzyme participates in valine, leucine and isoleucine biosynthesis.

References

    • Allaudeen HS, Ramakrishnan T (1968). "Biosynthesis of isoleucine and valine in Mycobacterium tuberculosis H37 Rv". Arch. Biochem. Biophys. 125 (1): 199–209. doi:10.1016/0003-9861(68)90655-3. PMID 4384955.


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