2010 SMU Mustangs football team

This game was the 48th meeting of the SMU Mustangs and the Texas Tech Red Raiders. The previous match-up was September 13, 2008, a game in which Texas Tech defeated SMU with a final score of 43–7. After the Mustangs lost in Lubbock, Texas Tech now leads the series 32–16. For his school-record 61 yard field goal, Matt Szymanski was named Conference USA Special Teams Player of the week.

This game will mark the 4th meeting of the SMU Mustangs and the UAB Blazers. They last met in the previous season on September 12, 2009, where SMU defeated UAB with a final score of 35 – 33. After the game, SMU now leads the series 4 – 0.

This game will mark the 2nd meeting of the SMU Mustangs and the Washington State Cougars. They last met in the previous season on September 19, 2009, where Washington State defeated SMU with a final score of 30 – 27. After the 2010 meeting, the series stands at 1 – 1. It was the first win for the Mustangs against a school from a BCS conference since they defeated Kansas 31-17 on September 2, 2000.

This game will mark the 89th meeting of the SMU Mustangs and the TCU Horned Frogs. They last met in the previous season on October 3, 2009, where TCU defeated SMU with a final score of 39 – 14. After the 2010 meeting, TCU leads the series 43 – 39 – 7. The two teams have a storied cross-town rivalry and will contend for the Iron Skillet trophy in the Battle for the Iron Skillet.

This game will mark the 88th meeting of the SMU Mustangs and the Rice Owls. They last met in the previous season on November 7, 2009, where SMU defeated Rice with a final score of 31 – 28. After the 2010 meeting, SMU now leads the series 47 – 40 – 1. The two teams have a storied cross-state rivalry and will contend for the Mayor's Cup trophy in the Battle for the Mayor's Cup. It was SMU's first win in Rice Stadium since 1986 before SMU received the Death Penalty for the 1987–88 seasons. Quarterback Kyle Padron was named Conference USA Offensive Player of the Week for his performance in the game which included three touchdowns, zero interceptions and 371 total yards.

This game will mark the 18th meeting of the SMU Mustangs and the Tulsa Golden Hurricane. They last met in the previous season on October 31, 2009, where SMU defeated Tulsa with a final score of 27 – 13. After SMU won the 2010 matchup, SMU now leads the series 12 – 6.

This game will mark the 15th meeting of the SMU Mustangs and the Navy Midshipmen. They last met in the previous season on October 17, 2009, where Navy defeated SMU with a final score of 38 – 35. After the 2010 meeting, Navy leads the series 8 – 7. The two schools now compete for the Gansz Trophy named after Frank Gansz who played a significant role in both school's football programs.

This game will mark the 26th meeting of the SMU Mustangs and the Houston Cougars. They last met in the previous season on October 24, 2009, where Houston defeated SMU with a final score of 38 – 15. After the 2010 meeting, Houston leads the series 16 – 9 – 1.

This game will mark the 19th meeting of the SMU Mustangs and the Tulane Green Wave. They last met in the previous season on November 28, 2009, where SMU defeated Tulane with a final score of 26 – 21. After the 2010 meeting, Tulane leads the series 12 – 7.

This game will mark the 18th meeting of the SMU Mustangs and the UTEP Miners. They last met in the previous season on November 14, 2009, where SMU defeated UTEP with a final score of 35 – 31. After losing 14-28, SMU leads the series 10 – 8.

This game will mark the 4th meeting of the SMU Mustangs and the Marshall Thundering Herd. They last met in the previous season on November 21, 2009, where Marshall defeated SMU with a final score of 34 – 31. After SMU won the 2010 match 31-17, the series is tied 2 – 2.

This game will mark the 4th meeting of the SMU Mustangs and the East Carolina Pirates. They last met in the previous season on October 10, 2009, where SMU defeated East Carolina with a final score of 28 – 21. After SMU's 45-38 victory, the series is now tied at 2 – 2.

This game will mark the 3rd meeting of the SMU Mustangs and the UCF Knights. They last met in 2008, where UCF defeated SMU with a final score of 31 – 17. The all-time series stands in UCF's favor 2-0.