2021 Major League Baseball postseason

1. Tampa Bay Rays – AL East champions, AL best record, 100–62[2]
2. Houston Astros – AL West champions, 95–67[3]
3. Chicago White Sox – AL Central champions, 93–69[4]
4. Boston Red Sox – 92–70 (10–9 head-to-head record vs. NYY)[5]
5. New York Yankees – 92–70 (9–10 head-to-head record vs. BOS)[6]

1. San Francisco Giants – NL West champions, NL best record, MLB best record, 107–55[7]
2. Milwaukee Brewers – NL Central champions, 95–67[8]
3. Atlanta Braves – NL East champions, 88–73[9]
4. Los Angeles Dodgers – 106–56[10]
5. St. Louis Cardinals – 90–72[11]

This was the fifth postseason meeting in the history of the Yankees–Red Sox rivalry. The Yankees defeated the Red Sox in the ALCS in 1999 and 2003, while the Red Sox defeated the Yankees in the 2004 ALCS and 2018 ALDS. The Red Sox defeated the Yankees 6–2 to advance to the ALDS. With the win, the Red Sox moved up to 3–2 all time meetings against the Yankees in the postseason.

This was the sixth postseason meeting between these two teams. The Cardinals defeated the Dodgers in the 1985 NLCS, 2004 NLDS, 2013 NLCS, and the 2014 NLDS. The one previous postseason meeting the Dodgers defeated the Cardinals was in the 2009 NLDS. The game remained tied into the bottom of the ninth inning, when the Dodgers' Chris Taylor hit a walk-off 2-run home run off Alex Reyes, giving the Dodgers a 3–1 victory and a ninth straight trip to the NLDS.

Boston won the series, 3–1.

This was the third postseason meeting between the Rays and Red Sox. The Rays won the 2008 ALCS, while the Red Sox struck back in the 2013 ALDS. The Red Sox defeated the top seeded Rays to advance to the ALCS for the first time since 2018. As of 2022, this is the most recent playoff series victory by the Red Sox.

Houston won the series, 3–1.

This was the second postseason meeting between the Astros and White Sox. When the team was still in the National League, the Astros met the White Sox in the 2005 World Series, which the White Sox won in a sweep to end the Curse of the Black Sox. The Astros defeated the White Sox in four games to advance to the ALCS for the fifth year in a row.

As of 2022, this is the last time the White Sox made the postseason.

Los Angeles won the series, 3–2.

This was the first postseason meeting in the history of the Dodgers–Giants rivalry, and the first NLDS series between two teams that had won 100 games or more in the regular season. The Dodgers upset MLB-best Giants in five games to advance to the NLCS for the fifth time in the past six years.

As of 2022, this is the last time the Giants have appeared in the postseason.

Atlanta won the series, 3–1.

This was the first postseason meeting between the Brewers and Braves. The Braves defeated the Brewers in four games to advance to the NLCS for the second year in a row.

Houston won the series, 4–2.

This was the third postseason meeting between the Red Sox and Astros. The two teams split the previous two meetings, in the 2017 ALDS (won by the Astros), and the 2018 ALCS (won by the Red Sox). In both instances, the winner was the eventual World Series champion. The Astros defeated the Red Sox in six games to advance to the World Series for the third time in five years.

Both teams split the first two games in Houston. When the series shifted to Boston, the Red Sox blew out the Astros by a 12–3 score to go up 2–1 in the series. However, their lead would not hold. The Red Sox were six defensive outs away from a 3–1 series lead before the Astros responded with a game-tying home run by José Altuve in the eighth inning and then exploded offensively with a seven-run ninth inning to even the series. Then Houston carried the momentum by blowing out the Red Sox in Game 5 to take a 3–2 series lead headed back to Houston. In Game 6, the Astros shut out the Red Sox to secure the pennant.

As of 2022, this is the last time the Red Sox have appeared in the postseason. The Astros would win the AL pennant again the next year, sweeping the New York Yankees.

Atlanta won the series, 4–2.

This was the fifth postseason matchup between the Dodgers and Braves. The previous meetings were the 1996 NLDS (won by the Braves), 2013 NLDS, 2018 NLDS, and 2020 NLCS (the latter three won by the Dodgers). The Braves pulled off a major upset of the defending World Series champion Dodgers in six games, and returned to the World Series for the first time since 1999.

Atlanta won the series, 4–2.

This was the first World Series played entirely in the South. The Astros and Braves had previously met in the postseason five times, all of which were in the NLDS when the Astros were still a National League team.[12] Of those five series, the Braves won three (1997, 1999, and 2001) while the Astros won two (2004 and 2005).[12] The Braves defeated the Astros in six games, capturing their first World Series title since 1995. The Braves took Game 1 in Houston to gain the home field advantage, while the Astros took Game 2 to tie the series. In Atlanta, the Braves shut out the Astros in Game 3, and defeated them by one run in Game 4 to go up three games to one. The Astros rallied to win Game 5 to send the series back to Houston, but the Braves would shut out the Astros for a second time in a blowout win to capture the title.

With the win, the Braves moved up to 4–2 all time against the Astros in the postseason. This was the third consecutive World Series won by the National League. With the loss, the Astros' record in the World Series fell to 1–3, with all three losses occurring at their home venue, Minute Maid Park.

The Braves returned to the postseason again the next year, but were upset by the Philadelphia Phillies in the NLDS, who went on a Cinderella run to the World Series. The Astros returned to the World Series again the next year, and defeated the aforementioned Phillies team in six games to win their second championship.