3-hydroxy-3-isohexenylglutaryl-CoA lyase

The enzyme 3-hydroxy-3-isohexenylglutaryl-CoA lyase (EC 4.1.3.26) catalyzes the chemical reaction

3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA 7-methyl-3-oxooct-6-enoyl-CoA + acetate
3-hydroxy-3-isohexenylglutaryl-CoA lyase
Identifiers
EC no.4.1.3.26
CAS no.37290-69-0
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins

This enzyme belongs to the family of lyases, specifically the oxo-acid-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is 3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA acetate-lyase (7-methyl-3-oxooct-6-enoyl-CoA-forming). Other names in common use include beta-hydroxy-beta-isohexenylglutaryl CoA-lyase, hydroxyisohexenylglutaryl-CoA:acetatelyase, 3-hydroxy-3-isohexenylglutaryl coenzyme A lyase, 3-hydroxy-3-isohexenylglutaryl-CoA isopentenylacetoacetyl-CoA-lyase, and 3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA acetate-lyase.

References

    • SEUBERT W, FASS E (1964). "[STUDIES ON THE BACTERIAL DEGRADATION OF ISOPRENOIDS. IV. THE PURIFICATION AND PROPERTIES OF BETA-ISOHEXENYLGLUTACONYL-COA-HYDRATASE AND BETA-HYDROXY-BETA-ISOHEXENYLGLUTARYL-COA-LYASE.]". Biochem. Z. 341: 23–34. PMID 14339651.


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