AKR1C2

Aldo-keto reductase family 1 member C2, also known as bile acid binding protein, 3α-hydroxysteroid dehydrogenase type 3, and dihydrodiol dehydrogenase type 2, is an enzyme that in humans is encoded by the AKR1C2 gene.[5]

AKR1C2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1IHI, 1J96, 1XJB, 2HDJ, 2IPJ, 4JQ1, 4JQ2, 4JQ3, 4JQ4, 4JQA, 4JTQ, 4JTR, 4L1W, 4L1X, 4XO6, 4XO7
Identifiers
Aliases	AKR1C2, AKR1C-pseudo, BABP, DD, DD2, DDH2, HAKRD, HBAB, MCDR2, SRXY8, TDD, DD-2, DD/BABP, aldo-keto reductase family 1, member C2, aldo-keto reductase family 1 member C2
External IDs	OMIM: 600450 MGI: 1924587 HomoloGene: 134114 GeneCards: AKR1C2
EC number	1.1.1.357
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10p15.1 Start 4,987,775 bp[1] End 5,018,031 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 A1 Start 4,624,074 bp[2] End 4,636,540 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in islet of Langerhans right lobe of liver gallbladder gastrocnemius muscle ascending aorta left coronary artery minor salivary gland tibial nerve Achilles tendon popliteal artery Top expressed in kidney proximal tubule morula secondary oocyte blastocyst spermatid adrenal gland liver jejunum submandibular gland More reference expression data BioGPS n/a
Gene ontology Molecular function trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity alditol:NADP+ 1-oxidoreductase activity phenanthrene 9,10-monooxygenase activity oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor bile acid binding carboxylic acid binding oxidoreductase activity ketosteroid monooxygenase activity alcohol dehydrogenase (NADP+) activity steroid dehydrogenase activity Cellular component cytoplasm cytosol Biological process prostaglandin metabolic process G protein-coupled receptor signaling pathway cellular response to jasmonic acid stimulus steroid metabolic process positive regulation of protein kinase B signaling epithelial cell differentiation daunorubicin metabolic process doxorubicin metabolic process lipid metabolism progesterone metabolic process digestion cellular response to prostaglandin D stimulus positive regulation of cell population proliferation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1646 77337 Ensembl ENSG00000151632 ENSMUSG00000021207 UniProt P52895 Q91WR5 RefSeq (mRNA) NM_001135241 NM_001354 NM_205845 NM_001321027 NM_001393392 NM_029901 RefSeq (protein) NP_001128713 NP_001307956 NP_001345 NP_995317 NP_084177 Location (UCSC) Chr 10: 4.99 – 5.02 Mb Chr 13: 4.62 – 4.64 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols using NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme binds bile acid with high affinity, and shows minimal 3α-hydroxysteroid dehydrogenase activity. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding two different isoforms have been found for this gene.[5]