ASF1B

Histone chaperone ASF1B is a protein that in humans is encoded by the ASF1B gene.[5][6][7]

ASF1B
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesASF1B, CIA-II, anti-silencing function 1B histone chaperone
External IDsOMIM: 609190 MGI: 1914179 HomoloGene: 56797 GeneCards: ASF1B
Orthologs
SpeciesHumanMouse
Entrez

55723

66929

Ensembl

ENSG00000105011
ENSG00000288210

ENSMUSG00000005470

UniProt

Q9NVP2

Q9DAP7

RefSeq (mRNA)

NM_018154

NM_024184

RefSeq (protein)

NP_060624

NP_077146

Location (UCSC)Chr 19: 14.12 – 14.14 MbChr 8: 84.68 – 84.7 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene encodes a member of the H3/H4 family of histone chaperone proteins and is similar to the anti-silencing function-1 gene in yeast. The encoded protein is the substrate of the tousled-like kinase family of cell cycle-regulated kinases, and may play a key role in modulating the nucleosome structure of chromatin by ensuring a constant supply of histones at sites of nucleosome assembly.[7]

Interactions

ASF1B has been shown to interact with TLK2,[6][8] CHAF1B,[5][8] TLK1[6][8] and CHAF1A.[5][8]

References

  1. ENSG00000288210 GRCh38: Ensembl release 89: ENSG00000105011, ENSG00000288210 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000005470 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Mello JA, Silljé HH, Roche DM, Kirschner DB, Nigg EA, Almouzni G (Apr 2002). "Human Asf1 and CAF-1 interact and synergize in a repair-coupled nucleosome assembly pathway". EMBO Reports. 3 (4): 329–34. doi:10.1093/embo-reports/kvf068. PMC 1084056. PMID 11897662.
  6. Silljé HH, Nigg EA (Jul 2001). "Identification of human Asf1 chromatin assembly factors as substrates of Tousled-like kinases". Current Biology. 11 (13): 1068–73. doi:10.1016/S0960-9822(01)00298-6. PMID 11470414. S2CID 8866062.
  7. "Entrez Gene: ASF1B ASF1 anti-silencing function 1 homolog B (S. cerevisiae)".
  8. Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

Further reading

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