CHAF1A

Chromatin assembly factor 1 subunit A is a protein that in humans is encoded by the CHAF1A gene.[5][6]

CHAF1A
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCHAF1A, CAF-1, CAF1, CAF1B, CAF1P150, P150, chromatin assembly factor 1 subunit A
External IDsOMIM: 601246 MGI: 1351331 HomoloGene: 4003 GeneCards: CHAF1A
Orthologs
SpeciesHumanMouse
Entrez

10036

27221

Ensembl

ENSG00000167670

ENSMUSG00000002835

UniProt

Q13111

Q9QWF0

RefSeq (mRNA)

NM_005483

NM_013733

RefSeq (protein)

NP_005474

NP_038761

Location (UCSC)Chr 19: 4.4 – 4.45 MbChr 17: 56.35 – 56.38 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

Chromatin assembly factor I (CAF-1) is a nuclear complex consisting of p50, p60 (CHAF1B; MIM 601245), and p150 (CHAF1A) subunits that assembles histone tetramers onto replicating DNA in vitro (Kaufman et al., 1995).[supplied by OMIM][6]

Interactions

CHAF1A has been shown to interact with:

References

  1. GRCh38: Ensembl release 89: ENSG00000167670 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000002835 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Kaufman PD, Kobayashi R, Kessler N, Stillman B (August 1995). "The p150 and p60 subunits of chromatin assembly factor I: a molecular link between newly synthesized histones and DNA replication". Cell. 81 (7): 1105–14. doi:10.1016/S0092-8674(05)80015-7. PMID 7600578. S2CID 13502921.
  6. "Entrez Gene: CHAF1A chromatin assembly factor 1, subunit A (p150)".
  7. Mello JA, Silljé HH, Roche DM, Kirschner DB, Nigg EA, Almouzni G (April 2002). "Human Asf1 and CAF-1 interact and synergize in a repair-coupled nucleosome assembly pathway". EMBO Rep. 3 (4): 329–34. doi:10.1093/embo-reports/kvf068. PMC 1084056. PMID 11897662.
  8. Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
  9. Jiao R, Bachrati CZ, Pedrazzi G, Kuster P, Petkovic M, Li JL, Egli D, Hickson ID, Stagljar I (June 2004). "Physical and functional interaction between the Bloom's syndrome gene product and the largest subunit of chromatin assembly factor 1". Mol. Cell. Biol. 24 (11): 4710–9. doi:10.1128/MCB.24.11.4710-4719.2004. PMC 416397. PMID 15143166.
  10. Reese BE, Bachman KE, Baylin SB, Rountree MR (May 2003). "The methyl-CpG binding protein MBD1 interacts with the p150 subunit of chromatin assembly factor 1". Mol. Cell. Biol. 23 (9): 3226–36. doi:10.1128/mcb.23.9.3226-3236.2003. PMC 153189. PMID 12697822.
  11. Lechner MS, Begg GE, Speicher DW, Rauscher FJ (September 2000). "Molecular determinants for targeting heterochromatin protein 1-mediated gene silencing: direct chromoshadow domain-KAP-1 corepressor interaction is essential". Mol. Cell. Biol. 20 (17): 6449–65. doi:10.1128/mcb.20.17.6449-6465.2000. PMC 86120. PMID 10938122.

Further reading


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