Alcohol dehydrogenase (azurin)

Alcohol dehydrogenase (azurin) (EC 1.1.9.1, type II quinoprotein alcohol dehydrogenase, quinohaemoprotein ethanol dehydrogenase, QHEDH, ADHIIB) is an enzyme with systematic name alcohol:azurin oxidoreductase.[1][2][3][4][5][6] This enzyme catalyses the following chemical reaction

primary alcohol + azurin aldehyde + reduced azurin
Alcohol dehydrogenase (azurin)
Identifiers
EC no.1.1.9.1
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Search
PMCarticles
PubMedarticles
NCBIproteins

This enzyme is a periplasmic PQQ-containing quinohemoprotein.

References
  1. Groen BW, van Kleef MA, Duine JA (March 1986). "Quinohaemoprotein alcohol dehydrogenase apoenzyme from Pseudomonas testosteroni". The Biochemical Journal. 234 (3): 611–5. doi:10.1042/bj2340611. PMC 1146615. PMID 3521592.
  2. de Jong GA, Caldeira J, Sun J, Jongejan JA, de Vries S, Loehr TM, Moura I, Moura JJ, Duine JA (July 1995). "Characterization of the interaction between PQQ and heme c in the quinohemoprotein ethanol dehydrogenase from Comamonas testosteroni". Biochemistry. 34 (29): 9451–8. doi:10.1021/bi00029a021. PMID 7626615.
  3. Toyama H, Fujii A, Matsushita K, Shinagawa E, Ameyama M, Adachi O (May 1995). "Three distinct quinoprotein alcohol dehydrogenases are expressed when Pseudomonas putida is grown on different alcohols". Journal of Bacteriology. 177 (9): 2442–50. doi:10.1128/jb.177.9.2442-2450.1995. PMC 176903. PMID 7730276.
  4. Matsushita K, Yamashita T, Aoki N, Toyama H, Adachi O (May 1999). "Electron transfer from quinohemoprotein alcohol dehydrogenase to blue copper protein azurin in the alcohol oxidase respiratory chain of Pseudomonas putida HK5". Biochemistry. 38 (19): 6111–8. doi:10.1021/bi990121f. PMID 10320337.
  5. Chen ZW, Matsushita K, Yamashita T, Fujii TA, Toyama H, Adachi O, Bellamy HD, Mathews FS (June 2002). "Structure at 1.9 A resolution of a quinohemoprotein alcohol dehydrogenase from Pseudomonas putida HK5". Structure. 10 (6): 837–49. doi:10.1016/s0969-2126(02)00774-8. PMID 12057198.
  6. Oubrie A, Rozeboom HJ, Kalk KH, Huizinga EG, Dijkstra BW (February 2002). "Crystal structure of quinohemoprotein alcohol dehydrogenase from Comamonas testosteroni: structural basis for substrate oxidation and electron transfer". The Journal of Biological Chemistry. 277 (5): 3727–32. doi:10.1074/jbc.M109403200. PMID 11714714.
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