Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase

Mannosyl-oligosaccharide 1,3-1,6-α-mannosidase (EC 3.2.1.114, mannosidase II, exo-1,3-1,6-α-mannosidase, α-D-mannosidase II, α-mannosidase II, α-3,6-mannosidase, GlcNAc transferase I-dependent α1,3[α1,6]mannosidase, Golgi α-mannosidase II, ManII, 1,3(1,6)-α-D-mannosidase, 1,3-(1,6-)mannosyl-oligosaccharide α-D-mannohydrolase) is an enzyme with systematic name (1→3)-(1→6)-mannosyl-oligosaccharide α-D-mannohydrolase.[1][2][3][4] It catalyses the hydrolysis of the terminal (1→3)- and (1→6)-linked α-D-mannose residues in the mannosyl-oligosaccharide Man5(GlcNAc)3.

Mannosyl-oligosaccharide 1,3-1,6-α-mannosidase
Identifiers
EC no.3.2.1.114
CAS no.82047-77-6
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
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PMCarticles
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NCBIproteins

This enzyme is involved in the synthesis of glycoproteins. It is a key enzyme of N-linked Glycan processing and is inhibited by small molecule swainsonine.[5]

References

  1. Harpaz N, Schachter H (May 1980). "Control of glycoprotein synthesis. Processing of asparagine-linked oligosaccharides by one or more rat liver Golgi α-D-mannosidases dependent on the prior action of UDP-N-acetylglucosamine: α-D-mannoside β 2-N-acetylglucosaminyltransferase I". The Journal of Biological Chemistry. 255 (10): 4894–902. PMID 6445359.
  2. Tulsiani DR, Hubbard SC, Robbins PW, Touster O (Apr 1982). "α-D-Mannosidases of rat liver Golgi membranes. Mannosidase II is the GlcNAcMAN5-cleaving enzyme in glycoprotein biosynthesis and mannosidases Ia and IB are the enzymes converting Man9 precursors to Man5 intermediates". The Journal of Biological Chemistry. 257 (7): 3660–8. PMID 7061502.
  3. Tulsiani DR, Opheim DJ, Touster O (May 1977). "Purification and characterization of α-D-mannosidase from rat liver Golgi membranes". The Journal of Biological Chemistry. 252 (10): 3227–33. PMID 863880.
  4. Athanasopoulos VI, Niranjan K, Rastall RA (Mar 2005). "The production, purification and characterisation of two novel α-D-mannosidases from Aspergillus phoenicis". Carbohydrate Research. 340 (4): 609–17. doi:10.1016/j.carres.2005.01.005. PMID 15721331.
  5. van den Elsen, J.M., Kuntz, D.A., Rose, D.R., "Structure of Golgi α-mannosidase II: a target for inhibition of growth and metastasis of cancer cells", EMBO Journal, 20(12): 3008–3017.
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