Ann E. Kelley

Ann Elizabeth Kelley (1954–2007) was an American neuroscientist, who specialized in the neuroscience of reward and behavior.[1] She was a professor at the University of Wisconsin.

Ann E. Kelley
Born
Milton, Massachusetts
Died
Madison, Wisconsin
NationalityAmerican
Education
Scientific career
FieldsNeuroscience
Institutions
Doctoral advisorSusan Iversen

Biography

Kelley was born in Milton, Massachusetts.[2] She became interested in neuroscience during a field trip to Harvard.[2] She completed her undergraduate studies at the University of Pennsylvania,[3][4] where she was captain for both the field hockey and lacrosse teams.[5][6] She then received a Thouron fellowship which allowed her to pursue a PhD at the University of Cambridge, England, under the supervision of Susan Iversen.[3] She was among the first 13 women to be admitted to Trinity College in 1976.[6] At Cambridge she continued to play lacrosse, and she was a member of the rowing team.[2] She continued her work at the Harvard Medical School with Walle Nauta.[7] Later, she held research and teaching positions at the University of Bordeaux in France, Harvard University and Northeastern University, before settling at the University of Wisconsin, where she was named Wisconsin Distinguished Neuroscience Professor in 2006.[4] At the University of Wisconsin, she was also Director of the Neuroscience Training Program.[7] In 2006, she was honored with Mika Salpeter Lifetime Achievement Award by the Society for Neuroscience.[5][8] She died from metastatic colon cancer on August 5, 2007 at her home in Madison, Wisconsin, at the age of 53.[9]

Kelley was an accomplished athlete, being a pioneering player for the women's lacrosse team and the field hockey team at the University of Pennsylvania.[3] She started a rowing eight at Cambridge and was stroke for the team.[6] She competed in the May Bumps in a women's four.[6] She was also an avid skier.[3]

Kelley was the mother of three children.[4]

Research

Kelley's research focused on the neuroscience of reward and behavior. She was a leading expert in the intracerebral microinfusion technique.[3]

During her PhD and the following years she studied the mesocorticostriatal systems and the role of opioids in interactions between the striatum and hypothalamic regulatory circuits in the control of behavior.[10][11][12] Following these studies she focused on eating behavior and food intake. She found that eating behavior was mediated by μ-opioids, but this was mechanism was dependent on the palatability of the food.[1]

She later performed studies to determine what part of the striatum was responsible for this mechanism. Together with Min Zhang she performed a microinfusion study that showed that the ventral and lateral areas of the striatum, including both the shell and the core of the nucleus accumbens, were most sensitive to injections of opioids causing behavioural changes.[10][13]

Together with Ned Kalin, Kelley demonstrated the role of the amygdala in the linking of sensory representations and their motivational value.[14][15] After lesioning the amygdala in rhesus monkeys, they found that the monkeys no longer learn proper fear responses to stimuli, such as a predator.[14][15]

During her time with Walle Nauta, she also performed anterograde and retrograde tracing studies to study the neural projections from the amygdala to the striatum.[14][16] They showed that these projection were much more extensive than previously thought, and that the amygdala innervates large parts of the caudal striatum.[14][16] As the amygdala is involved in motivation they speculated that the striatum may in fact also be mediated in a large part by motivation.[14][16]

Kelly furthermore showed that food can act as an addictive substance.[8][17][18] She found that the consumption of salty and sweet foods was influenced injection of a μ-opioid antagonist into the nucleus accumbens in a similar way the intake of alcohol, but not the intake of water, was.[17][19]

Legacy

Two years after her death, Kelley posthumously received the Patricia Goldman-Rakic Hall of Honor award by the Society for Neuroscience.[8] The University of Wisconsin-Madison established the Ann E. Kelley Fellowship in Behavioral Science in her honour.[3] Kelley's alma mater, the University of Pennsylvania, established the Ann E. Kelley Memorial Scholarship in 2007.[3] In 2013 the journal Neuroscience & Biobehavioral Reviews dedicated a volume to her.[20]

References
  1. Richard, Jocelyn M.; Castro, Daniel C.; DiFeliceantonio, Alexandra G.; Robinson, Mike J.F.; Berridge, Kent C. (2013). "Mapping brain circuits of reward and motivation: In the footsteps of Ann Kelley". Neuroscience & Biobehavioral Reviews. 37 (9): 1919–1931. doi:10.1016/j.neubiorev.2012.12.008. PMC 3706488. PMID 23261404.
  2. Lawrence, J.M. (September 7, 2007). "Ann Kelley; studied fast-food's effect on brain". The Boston Globe. Retrieved 2019-01-05.
  3. "Ann E. Kelley Award". UW Department of Psychiatry. Retrieved 2019-01-05.
  4. "Obituary Ann E Kelley". Legacy. Retrieved 5 January 2019.
  5. "A Death in the "Family"" (PDF). www.thouronaward.org. Retrieved 2019-01-05.
  6. Pepall, Lynne; Ewing, Ann; Hamblen, Jane (Winter 2017). "The first First and Third women's boat" (PDF). The Fountain (23): 16–17. Archived from the original (PDF) on 2019-01-06. Retrieved 2019-01-05.
  7. Bakshi, Vaishali P.; Baldo, Brian A.; Kalin, Ned (2008). "Ann E Kelley 1954–2007" (PDF). Neuropsychopharmacology. 33 (13): 3246. doi:10.1038/sj.npp.1301632. S2CID 12277885.
  8. "Society for Neoroscience Announces Science Achievement Awards". web.sfn.org. Retrieved 2019-01-05.
  9. Cunningham, Kathryn A.; Napier, T. Celeste (2008). "Ann Elizabeth Kelley (1954-2007)". American Psychologist. 63 (7): 615–616. doi:10.1037/0003-066X.63.7.615.
  10. Richard, Jocelyn M.; Castro, Daniel C.; Difeliceantonio, Alexandra G.; Robinson, Mike J.F.; Berridge, Kent C. (2013). "Mapping brain circuits of reward and motivation: In the footsteps of Ann Kelley". Neuroscience & Biobehavioral Reviews. 37 (9): 1919–1931. doi:10.1016/j.neubiorev.2012.12.008. PMC 3706488. PMID 23261404.
  11. Kelle, Ann E.; Stinus, Louis; Iversen, Susan D. (1980). "Interactions between d-Ala-Met-enkephalin, A10 dopaminergic neurones, and spontaneous behaviour in the rat". Behavioural Brain Research. 1 (1): 3–24. doi:10.1016/0166-4328(80)90043-1. PMID 6269560. S2CID 4030620.
  12. Kelley, Ann E.; Iversen, Susan D. (1978). "Behavioural response to bilateral injections of substance P into the substantia nigra of the rat". Brain Research. 158 (2): 474–478. doi:10.1016/0006-8993(78)90693-5. PMID 709379. S2CID 6583639.
  13. Zhang, M.; Kelley, A.E (2000). "Enhanced intake of high-fat food following striatal mu-opioid stimulation: Microinjection mapping and Fos expression". Neuroscience. 99 (2): 267–277. doi:10.1016/S0306-4522(00)00198-6. PMID 10938432. S2CID 24922601.
  14. Zorrilla, Eric P.; Koob, George F. (2013). "Amygdalostriatal projections in the neurocircuitry for motivation: A neuroanatomical thread through the career of Ann Kelley". Neuroscience & Biobehavioral Reviews. 37 (9): 1932–1945. doi:10.1016/j.neubiorev.2012.11.019. PMC 3838492. PMID 23220696.
  15. Kalin, Ned H.; Shelton, Steven E.; Davidson, Richard J.; Kelley, Ann E. (2001). "The Primate Amygdala Mediates Acute Fear but Not the Behavioral and Physiological Components of Anxious Temperament". The Journal of Neuroscience. 21 (6): 2067–2074. doi:10.1523/JNEUROSCI.21-06-02067.2001. PMC 6762619. PMID 11245690.
  16. Kelley, A. E.; Domesick, V. B.; Nauta, W. J. H. (1982). "The Amygdalostriatal Projection in the Rat—An Anatomical Study by Anterograde and Retrograde Tracing Methods". Neuroanatomy. pp. 495–509. doi:10.1007/978-1-4684-7920-1_24. ISBN 978-1-4684-7922-5.
  17. "Fast food 'as addictive as heroin'". 2003-01-30. Retrieved 2019-01-05.
  18. "Fast food is addictive in same way as drugs, say scientists". The Independent. 2003-01-30. Archived from the original on 2022-05-07. Retrieved 2019-01-05.
  19. Zhang, Min; Kelley, Ann (2002). "Intake of saccharin, salt, and ethanol solutions is increased by infusion of a mu opioid agonist into the nucleus accumbens". Psychopharmacology. 159 (4): 415–423. doi:10.1007/s00213-001-0932-y. PMID 11823894. S2CID 2204399.
  20. "Ann Kelley: Dedication". Neuroscience & Biobehavioral Reviews. 37 (9): 1918. 2013. doi:10.1016/j.neubiorev.2013.08.008. PMID 23993947. S2CID 9210488.
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