Fluticasone furoate

Fluticasone furoate, sold under the brand name Flonase Sensimist among others, is a corticosteroid for the treatment of non-allergic and allergic rhinitis administered by a nasal spray.[8] It is also available as an inhaled corticosteroid to help prevent and control symptoms of asthma. It is derived from cortisol.[9] Unlike fluticasone propionate, which is only approved for children four years and older, fluticasone furoate is approved in children as young as two years of age when used for allergies.[5][10]

For other uses, see Fluticasone.

Fluticasone furoate
Clinical data
Trade namesFlonase Sensimist, Veramyst, Arnuity Ellipta, others
AHFS/Drugs.comMonograph
License data
Pregnancy
category
Routes of
administration		Intranasal, by mouth
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailability0.51% (Intranasal)
Protein binding91%
MetabolismIntranasal
Liver (CYP3A4-mediated)
Elimination half-life15 hours
ExcretionKidney
Identifiers
  • (6α,11β,16α,17α)-6,9-difluoro-17-{[(fluoro-methyl)thio]carbonyl}-11-hydroxy-16-methyl-3-oxoandrosta-1,4-dien-17-yl 2-furancarboxylate
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.158.130
Chemical and physical data
FormulaC27H29F3O6S
Molar mass538.58 g·mol−1
3D model (JSmol)
  • CC1CC2C3CC(C4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)SCF)OC(=O)C5=CC=CO5)C)O)F)C)F
  • InChI=1S/C27H29F3O6S/c1-14-9-16-17-11-19(29)18-10-15(31)6-7-24(18,2)26(17,30)21(32)12-25(16,3)27(14,23(34)37-13-28)36-22(33)20-5-4-8-35-20/h4-8,10,14,16-17,19,21,32H,9,11-13H2,1-3H3/t14-,16+,17+,19+,21+,24+,25+,26+,27+/m1/s1
  • Key:XTULMSXFIHGYFS-VLSRWLAYSA-N

It was approved for medical use in the United States in April 2007, and in the European Union in November 2008.[11][7] In 2020, fluticasone was the 23rd most commonly prescribed medication in the United States, with more than 24 million prescriptions.[12][13]

Medical uses

Fluticasone furoate is indicated for the treatment of the symptoms of allergic rhinitis[7] and asthma.[5][6]

Society and culture

Brand names

In the US it is marketed by GlaxoSmithKline for asthma as Arnuity Ellipta and is only available with a prescription.[6] It is sold over-the-counter for allergic rhinitis as Flonase Sensimist.[5] The Veramyst brand name was discontinued in the US.[5][10]

The combination drugs fluticasone furoate/umeclidinium bromide/vilanterol, marketed as Trelegy Ellipta, and fluticasone furoate/vilanterol, marketed as Breo Ellipta (US, Canada, New Zealand) and Relvar Ellipta (EU, UK),[14][15][16] are approved for use in the United States for long-term maintenance treatment of airflow obstruction in people with chronic obstructive pulmonary disease (COPD).[14] They are also approved for the treatment of asthma.[14][17]

The combination fluticasone propionate/salmeterol (Advair Diskus) is indicated for the treatment of asthma and chronic obstructive pulmonary disease.[18]

References
  1. "Fluticasone Use During Pregnancy". Drugs.com. 9 January 2019. Archived from the original on 26 March 2019. Retrieved 4 February 2020.
  2. "AVAMYS fluticasone furoate nasal spray bottle (131443)". Department of Health and Ages Care. Archived from the original on 2 March 2023. Retrieved 1 April 2023.
  3. "Arnuity Elliptafluticasone furoate 50 microgram powder for inhalation dry powder inhaler (300141)". Department of Health and Ages Care. Archived from the original on 2 March 2023. Retrieved 1 April 2023.
  4. "Avamys 27.5 micrograms/spray, nasal spray suspension - Summary of Product Characteristics (SmPC)". (emc). 4 June 2021. Archived from the original on 8 June 2023. Retrieved 18 June 2023.
  5. "Flonase Sensimist Allergy Relief- fluticasone furoate spray, metered". DailyMed. 30 May 2019. Archived from the original on 2 December 2020. Retrieved 4 February 2020.
  6. "Arnuity Ellipta- fluticasone furoate powder". DailyMed. 26 June 2019. Archived from the original on 7 December 2019. Retrieved 4 February 2020.
  7. "Avamys EPAR". European Medicines Agency (EMA). 17 September 2018. Archived from the original on 5 June 2020. Retrieved 5 June 2020.
  8. Bruni FM, De Luca G, Venturoli V, Boner AL (2009). "Intranasal corticosteroids and adrenal suppression". Neuroimmunomodulation. 16 (5): 353–62. doi:10.1159/000216193. PMID 19571596. S2CID 35006163. Archived from the original on 18 May 2019. Retrieved 18 May 2019.
  9. Kaliner, Michael A. (2011). Rhinitis, An Issue of Immunology and Allergy Clinics - E-Book. Elsevier Health Sciences. ISBN 9781455709328.
  10. "Veramyst- fluticasone furoate spray, metered". DailyMed. 1 March 2010. Archived from the original on 5 February 2020. Retrieved 4 February 2020.
  11. "Drug Approval Package: Veramyst (fluticasone furoate) NDA #022051". U.S. Food and Drug Administration (FDA). 30 August 2010. Archived from the original on 5 February 2020. Retrieved 4 February 2020.
  12. "The Top 300 of 2020". ClinCalc. Archived from the original on 12 February 2021. Retrieved 7 October 2022.
  13. "Fluticasone - Drug Usage Statistics". ClinCalc. Archived from the original on 12 April 2020. Retrieved 7 October 2022.
  14. "Breo Ellipta- fluticasone furoate and vilanterol trifenatate powder". DailyMed. 7 January 2019. Archived from the original on 26 May 2020. Retrieved 4 February 2020.
  15. "Relvar Ellipta 92 micrograms/22 micrograms inhalation powder, pre-dispensed - Summary of Product Characteristics (SmPC)". (emc). 3 January 2019. Archived from the original on 5 February 2020. Retrieved 4 February 2020.
  16. "Relvar Ellipta EPAR". European Medicines Agency (EMA). 17 September 2018. Archived from the original on 5 February 2020. Retrieved 4 February 2020.
  17. "Is Trelegy used for asthma?". Drugs.com. Archived from the original on 18 April 2023. Retrieved 18 April 2023.
  18. "Advair Diskus- fluticasone propionate and salmeterol powder". DailyMed. 20 October 2020. Archived from the original on 31 May 2023. Retrieved 18 June 2023.


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.