Basal cell adhesion molecule

Basal cell adhesion molecule, also known as Lutheran antigen, is a plasma membrane glycoprotein that in humans is encoded by the BCAM gene.[5] BCAM has also recently been designated CD239 (cluster of differentiation 239).

BCAM
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesBCAM, AU, CD239, LU, MSK19, basal cell adhesion molecule (Lutheran blood group)
External IDsOMIM: 612773 MGI: 1929940 HomoloGene: 21149 GeneCards: BCAM
Orthologs
SpeciesHumanMouse
Entrez

4059

57278

Ensembl

ENSG00000187244

ENSMUSG00000002980

UniProt

P50895

Q9R069

RefSeq (mRNA)

NM_005581
NM_001013257

NM_020486

RefSeq (protein)

NP_001013275
NP_005572

NP_065232

Location (UCSC)Chr 19: 44.81 – 44.82 MbChr 7: 19.49 – 19.5 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

Lutheran blood group glycoprotein is a member of the immunoglobulin superfamily and a receptor for the extracellular matrix protein, laminin. The protein contains five, N-terminus, extracellular immunoglobulin domains, a single transmembrane domain, and a short, C-terminal cytoplasmic tail. This protein may play a role in epithelial cell cancer and in vaso-occlusion of red blood cells in sickle cell disease. Two transcript variants encoding different isoforms have been found for this gene.[5]

Interactions

BCAM has been shown to interact with Laminin, alpha 5. BCAM has also been shown to promote the metastasis of ovarian cancer.[6][7][8]

References

  1. GRCh38: Ensembl release 89: ENSG00000187244 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000002980 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: BCAM basal cell adhesion molecule (Lutheran blood group)".
  6. Parsons SF, Lee G, Spring FA, Willig TN, Peters LL, Gimm JA, Tanner MJ, Mohandas N, Anstee DJ, Chasis JA (2001). "Lutheran blood group glycoprotein and its newly characterized mouse homologue specifically bind alpha5 chain-containing human laminin with high affinity". Blood. 97 (1): 312–20. doi:10.1182/blood.v97.1.312. PMID 11133776. S2CID 10715366.
  7. Kikkawa Y, Moulson CL, Virtanen I, Miner JH (2002). "Identification of the binding site for the Lutheran blood group glycoprotein on laminin alpha 5 through expression of chimeric laminin chains in vivo". J. Biol. Chem. 277 (47): 44864–9. doi:10.1074/jbc.M208731200. PMID 12244066.
  8. Sivakumar S, Lieber S, Librizzi D (2023). "Basal cell adhesion molecule promotes metastasis-associated processes in ovarian cancer". Clin Transl Med. 13 (1). doi:10.1002/ctm2.1176. PMID 36647260.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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